Loading next page...
/lp/american-medical-association/inhibition-of-immune-corneal-graft-rejection-by-azathioprine-imuran-ZDf36Ho3LZ
- Publisher
- American Medical Association
- Copyright
- Copyright © 1965 American Medical Association. All Rights Reserved.
- ISSN
- 0003-9950
- eISSN
- 1538-3687
- DOI
- 10.1001/archopht.1965.00970040685018
- Publisher site
- See Article on Publisher Site
Abstract
Abstract Penetrating corneal homografts in vascularized rabbit corneas are regularly rejected if skin from the corneal donor is grafted to the corneal recipient.1-4 The delayed graft reaction and the similarity of the clinical picture in experimental and in human grafts point to a common immunological type of reaction. Corneal vascularization is required for the experimental immune rejection of corneal homografts;5-6 in its absence, even lamellar heterografts can remain clear indefinitely.6-7 One of the problems found in clinical cases of corneal homotransplantation is how to prevent the late corneal graft rejection (or graft sickness) when the transplant has been done in a vascularized host. To a certain extent, corticosteroids can prevent or diminish the reaction,6 but in most cases, they fail to prevent opacification of the transplant. The successful use of antimetabolites, especially 6-mercaptopurine (6-MP) and its derivative azathioprine, in preventing the rejection of highly vascularized organs such References 1. Maumenee, A.E.: The Influence of Donor-Recipient Sensitization on Corneal Grafts , Amer J Ophthal 34:142, 1951. 2. Mueller, H., and Maumenee, A.E.: Considerations sur la maladie du greffon , Arch Ophthal 11:146, 1951. 3. Greaves, D.P.: Experimental Penetrating Keratoplasty , Coll Rep Inst Ophthal 7:135, 1954-1955. 4. Polack, F.M.: Histological and Histochemical Alterations in the Early Stages of Corneal Graft Rejection , J Exp Med 116:709, 1962.Crossref 5. Maumenee, A.E.: The Immune Concept: Its Relation to Corneal Homotransplantation , Ann NY Acad Med 59: 453, 1955.Crossref 6. Maumenee, A.E.: Clinical Aspects of the Corneal Homograft Reaction , Invest Ophthal 1:244, 1962. 7. Polack, F.M.; Smelser, G.K.; and Rose, J.: The Fate of Cells in Heterologous Corneal Transplants , Invest Ophthal 4:355, 1963. 8. Calne, R.Y.: The Rejection of Renal Homografts: Inhibition in Dogs by 6-Mercapto Purine , Lancet 1:417, 1960.Crossref 9. Zukowski, C.F., et al: The Prolongation of Functional Survival of Canine Renal Homografts by 6-Mercapto Purine , Surg Forum 11:470, 1960. 10. Calne, R.Y.: Inhibition of the Rejection of Renal Homografts in Dogs by Burroughs Wellcome 57, 322 , Surg Forum 12:118, 1961. 11. Calne, R.Y.: Inhibition of the Rejection of Renal Homografts in Dogs by Purine Analogs , Transplantation 28:65, 1961. 12. Cleasby, G.W., and Byland, S.S.: Modification of the Homograft Reaction in Corneal Transplantation: A Preliminary Report , Ann NY Acad Sci 120:802, 1964.Crossref 13. Robert, L.; Parlebas, J.; Poullain, N.; and Robert, B.: Protides of the Biological Fluids , H. Peeters (ed.), New York: Elsevier Publishing Company, 1964, vol II, p 109. 14. Murray, J.E., et al: Reversibility of the Kidney Homograft Reaction by Retransplantation and Drug Therapy , Ann NY Acad Sci 99:768, 1962.Crossref 15. Hitchings, G.H., and Elion, G.B.: Chemical Suppression of the Immune Response , Pharmacol Rev 15:365, 1963. 16. Berenbaum, M.C.: Effect of Cytotoxic Agent on Antibody Production , Nature 185:167, 1960.Crossref 17. Dixon, F.J., et al: Radiosensitive and Radioresistant Phases in the Antibody Response , J Immun 68:693, 1952. 18. Berenbaum, M.C.: The Action of Antimitotic Substances on the Immune Response , Path Biol 9:963, 1961. 19. Berenbaum, M.C.: The Effect of Cytotoxic Agents on the Production of Antibody to TAB Vaccine in the Mouse , Biochem Pharmacol 11:29, 1962.Crossref 20. Rundles, R.W., et al: Clinical and Hematological Study of 6 (1-Methyl-4-Nitro-5 Imidazolyl-Thio) Purine, (b.W. 57-322) and Related Compounds , Cancer Chemother Rep 14:99, 1961. 21. Elion, G.B.: Personal communication to the author. 22. Andre, J.A., et al: The Morphologic Responses of the Lymphoid System to Homografts. II. The Effect of Anti-Metabolites , Blood 19:334, 1962. 23. Borel, Y., and Schwartz, R.: Inhibition of Immediate and Delayed Hypersensitivity in the Rabbit by 6-Mercapto Purine , J Immunol 92:755, 1964. 24. Murray, J.E., et al: Kidney Transplantation in Modified Recipients , Ann Surg 156:337, 1962.Crossref 25. Starzl, T.E., et al: Problems in Renal Homotransplantation , JAMA 187:734, 1964.Crossref 26. Zukowski, C.F.: Canine Renal Homografts , JAMA 191:1017, 1965.Crossref 27. Kretschner, R.R., and Perez-Tamyo, R.: The Role of Humoral Antibodies in Reiection of Skin Homografts in Rabbits , J Exp Med 116:879, 1962.Crossref 28. Parks, J.J.; Howard, M.I.; Leibowitz, H.; and Maumenee, A.E.: A Transient Stage of Suspected Delayed Sensitivity During the Early Induction Phase of Immediate Corneal Sensitivity , J Exp Med 115:867, 1962.Crossref 29. Leibowitz, H., and Elliott, J.: Anti-Metabolite Suppression of Corneal Hypersensitivity , Arch Ophthal 73:94, 1965.Crossref 30. Pierce, J.C., and Varco, R.L.: Induction of Tolerance to a Canine Renal Homograft Homotransplant With 6-Mercapto Purine , Lancet 1:781, 1962.Crossref 31. Urrets-Zavalia, A., Jr.: Personal communication to the author. 32. Billingham, R.E., and Boswell, T.: Studies on the Problem of Corneal Homografts , Proc Royal Soc 141:392, 1953.Crossref
Journal
Archives of Ophthalmology – American Medical Association
Published: Nov 1, 1965
@Phil_Robichaud
@deepthiw
@JoseServera