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Inherited Patterned Lentiginosis in Blacks

Inherited Patterned Lentiginosis in Blacks Abstract † We present 10 patients with autosomal dominant transmission of a pigmentary pattern characterized by facial, lip, extremity, buttock, and palmoplantar small, discrete hyperpigmented macules. None of the patients had lesions of the oral mucosa or internal organ system abnormalities. These patients' pigmentary pattern can resemble the ones seen in other lentiginosis syndromes. Those most closely mimicked—the Peutz-Jeghers syndrome, the centrofacial lentiginosis syndrome, and Carney's syndrome—all have associated internal abnormalities. We believe the pattern of pigmentation in these 10 black patients is distinct. (Arch Dermatol. 1989;125:1231-1235) References 1. Fulk CS. Primary disorders of hyperpigmentation . J Am Acad Dermatol. 1984;10:1-15.Crossref 2. Dormandy TL. Gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jeghers syndrome) . N Engl J Med. 1957;256:1093-1102, 1141-1146, 1186-1190.Crossref 3. Jeghers H, McKusick VA, Katz KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits . N Engl J Med. 1949;241:992-1005, 1031-1036.Crossref 4. Peutz JL. On a very remarkable case of familial polyposis . Ned Maandschr Geneeskd. 1921;10:134-146. 5. Calnan CD. The Peutz-Jeghers syndrome . Trans St John's Hosp Dermatol Soc. 1960;44:58-64. 6. Bartholomew LG, Moore CE, Dahlin DC, Waugh JM. Intestinal polyposis associated with mucocutaneous pigmentation . Surg Gynecol Obstet. 1962;115:1-11. 7. Utsunomiya J, Gocho H, Miyanaga T, Hamaguchi F, Kashimure A. Peutz-Jeghers syndrome: its natural course and management . Johns Hopkins Med J. 1975;136:71-82. 8. Giardello FM, Welsh SB, Hamilyon SR, et al. Increased risk of cancer in the Peutz-Jeghers syndrome . N Engl J Med. 1987; 316:1511-1514.Crossref 9. Dociu I, Galaction-Nitelea O, Sirjita N, Murgu V. Centrofacial lentiginosis . Br J Dermatol. 1976;94:39-43.Crossref 10. Selmanowitz VJ, Orentreich N, Felsenstein JM. Lentiginosis profusa syndrome (multiple lentigines syndrome) . Arch Dermatol. 1971;104:393-401.Crossref 11. Moynahan EJ. Multiple symmetrical moles, with psychic and somatic infantilism and genital hypognoplasia: first male case of a new syndrome . Proc R Soc Med. 1962;55:959-960. 12. Seuanez H, Mane-Garzon F, Kolski R. Cardio-cutaneous syndrome (the `LEOPARD' syndrome): review of the literature and a new family . Clin Genet. 1976;9:266-276.Crossref 13. Voron DA, Hatfield HH, Kalkhoff RK. Multiple lentigines syndrome: case report and review of the literature . Am J Med. 1976;60:447-456.Crossref 14. Rees JR, Ross FGM, Keen G. Lentiginosis and left atrial myxoma . Br Heart J. 1973;35:874-876.Crossref 15. Reed OM, Mellete JR, Fitzpatrick JE. Cutaneous lentiginosis with atrial myxomas . J Am Acad Dermatol. 1986;15:398-402.Crossref 16. Carney JA, Gordon H, Carpenter PG, Shenoy BV, Go VLW. The complex of myxomas, spotty pigmentation, and endocrine overactivity . Medicine . 1985;64:270-283.Crossref 17. Carney JA, Hrusko LS, Beauchamp GD, Gordon H. Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity . Mayo Clin Proc. 1986;61:165-172.Crossref 18. Atherton DJ, Pitcher DW, Wells RS, Macdonald DM. A syndrome of various cutaneous pigmented lesions, myxoid neurofibromata and atrial myxoma: the NAME syndrome . Br J Dermatol. 1980;103:421-429.Crossref 19. Rhodes AR, Silverman RA, Harrist TJ, Perez-Atayde AR. Mucocutaneous lentigines, cardiomucocutaneous myxomas, and multiple blue nevi: the `LAMB' syndrome . J Am Acad Dermatol. 1984;10:72-82.Crossref 20. Kostant G, Gellin GA. Peutz-Jeghers syndrome (forme fruste) . Arch Dermatol. 1963;88:361-363. 21. Uhle P, Norvell SS. Generalized lentiginosis . J Am Acad Dermatol. 1988;18:444-447.Crossref 22. Korting GW, Dent R. Differential Diagnosis in Dermatology . Philadelphia, Pa: WB Saunders Co, 1976:397. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Inherited Patterned Lentiginosis in Blacks

Archives of Dermatology , Volume 125 (9) – Sep 1, 1989

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670210069009
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See Article on Publisher Site

Abstract

Abstract † We present 10 patients with autosomal dominant transmission of a pigmentary pattern characterized by facial, lip, extremity, buttock, and palmoplantar small, discrete hyperpigmented macules. None of the patients had lesions of the oral mucosa or internal organ system abnormalities. These patients' pigmentary pattern can resemble the ones seen in other lentiginosis syndromes. Those most closely mimicked—the Peutz-Jeghers syndrome, the centrofacial lentiginosis syndrome, and Carney's syndrome—all have associated internal abnormalities. We believe the pattern of pigmentation in these 10 black patients is distinct. (Arch Dermatol. 1989;125:1231-1235) References 1. Fulk CS. Primary disorders of hyperpigmentation . J Am Acad Dermatol. 1984;10:1-15.Crossref 2. Dormandy TL. Gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jeghers syndrome) . N Engl J Med. 1957;256:1093-1102, 1141-1146, 1186-1190.Crossref 3. Jeghers H, McKusick VA, Katz KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits . N Engl J Med. 1949;241:992-1005, 1031-1036.Crossref 4. Peutz JL. On a very remarkable case of familial polyposis . Ned Maandschr Geneeskd. 1921;10:134-146. 5. Calnan CD. The Peutz-Jeghers syndrome . Trans St John's Hosp Dermatol Soc. 1960;44:58-64. 6. Bartholomew LG, Moore CE, Dahlin DC, Waugh JM. Intestinal polyposis associated with mucocutaneous pigmentation . Surg Gynecol Obstet. 1962;115:1-11. 7. Utsunomiya J, Gocho H, Miyanaga T, Hamaguchi F, Kashimure A. Peutz-Jeghers syndrome: its natural course and management . Johns Hopkins Med J. 1975;136:71-82. 8. Giardello FM, Welsh SB, Hamilyon SR, et al. Increased risk of cancer in the Peutz-Jeghers syndrome . N Engl J Med. 1987; 316:1511-1514.Crossref 9. Dociu I, Galaction-Nitelea O, Sirjita N, Murgu V. Centrofacial lentiginosis . Br J Dermatol. 1976;94:39-43.Crossref 10. Selmanowitz VJ, Orentreich N, Felsenstein JM. Lentiginosis profusa syndrome (multiple lentigines syndrome) . Arch Dermatol. 1971;104:393-401.Crossref 11. Moynahan EJ. Multiple symmetrical moles, with psychic and somatic infantilism and genital hypognoplasia: first male case of a new syndrome . Proc R Soc Med. 1962;55:959-960. 12. Seuanez H, Mane-Garzon F, Kolski R. Cardio-cutaneous syndrome (the `LEOPARD' syndrome): review of the literature and a new family . Clin Genet. 1976;9:266-276.Crossref 13. Voron DA, Hatfield HH, Kalkhoff RK. Multiple lentigines syndrome: case report and review of the literature . Am J Med. 1976;60:447-456.Crossref 14. Rees JR, Ross FGM, Keen G. Lentiginosis and left atrial myxoma . Br Heart J. 1973;35:874-876.Crossref 15. Reed OM, Mellete JR, Fitzpatrick JE. Cutaneous lentiginosis with atrial myxomas . J Am Acad Dermatol. 1986;15:398-402.Crossref 16. Carney JA, Gordon H, Carpenter PG, Shenoy BV, Go VLW. The complex of myxomas, spotty pigmentation, and endocrine overactivity . Medicine . 1985;64:270-283.Crossref 17. Carney JA, Hrusko LS, Beauchamp GD, Gordon H. Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity . Mayo Clin Proc. 1986;61:165-172.Crossref 18. Atherton DJ, Pitcher DW, Wells RS, Macdonald DM. A syndrome of various cutaneous pigmented lesions, myxoid neurofibromata and atrial myxoma: the NAME syndrome . Br J Dermatol. 1980;103:421-429.Crossref 19. Rhodes AR, Silverman RA, Harrist TJ, Perez-Atayde AR. Mucocutaneous lentigines, cardiomucocutaneous myxomas, and multiple blue nevi: the `LAMB' syndrome . J Am Acad Dermatol. 1984;10:72-82.Crossref 20. Kostant G, Gellin GA. Peutz-Jeghers syndrome (forme fruste) . Arch Dermatol. 1963;88:361-363. 21. Uhle P, Norvell SS. Generalized lentiginosis . J Am Acad Dermatol. 1988;18:444-447.Crossref 22. Korting GW, Dent R. Differential Diagnosis in Dermatology . Philadelphia, Pa: WB Saunders Co, 1976:397.

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1989

References