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Inheritance of Pseudohypoparathyroidism

Inheritance of Pseudohypoparathyroidism Abstract Sir.—The report of Tsang and associates1 was of great interest; however, its value was somewhat marred by the lack of an adequate family history. McKusick2 has summarized some of the questions that remain about the inheritance of pseudohypoparathyroidism, ie, dominant, sex-linked, and recessive forms may exist. Despite clinical similarity, however, genetic heterogeneity suggests the possibility of different pathways. For this reason it is important to document the pattern of inheritance; otherwise, lessons from one form might inappropriately be applied to another. While we are informed in the report of an affected sister, information is entirely lacking on the parents. Are they normal, or is one or the other affected? If one is affected, to what degree? Certainly the heterogeneity of expression of a single gene within a family is also important to our understanding. In this respect some mention of the presence or absence of other frequent References 1. Tsang RC, Venkataraman P, Ho M, et al: The development of pseudohypoparathyroidism . AJDC 1984;138:654-658. 2. McKusick V: Mendelian Inheritance in Man , ed 6. Baltimore, Johns Hopkins University Press, 1983, pp 988-989. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Inheritance of Pseudohypoparathyroidism

American Journal of Diseases of Children , Volume 139 (3) – Mar 1, 1985

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1985.02140050014004
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The report of Tsang and associates1 was of great interest; however, its value was somewhat marred by the lack of an adequate family history. McKusick2 has summarized some of the questions that remain about the inheritance of pseudohypoparathyroidism, ie, dominant, sex-linked, and recessive forms may exist. Despite clinical similarity, however, genetic heterogeneity suggests the possibility of different pathways. For this reason it is important to document the pattern of inheritance; otherwise, lessons from one form might inappropriately be applied to another. While we are informed in the report of an affected sister, information is entirely lacking on the parents. Are they normal, or is one or the other affected? If one is affected, to what degree? Certainly the heterogeneity of expression of a single gene within a family is also important to our understanding. In this respect some mention of the presence or absence of other frequent References 1. Tsang RC, Venkataraman P, Ho M, et al: The development of pseudohypoparathyroidism . AJDC 1984;138:654-658. 2. McKusick V: Mendelian Inheritance in Man , ed 6. Baltimore, Johns Hopkins University Press, 1983, pp 988-989.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1985

References

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