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ARTICLE Influenza Vaccine Effectiveness Among Children 6 to 59 Months of Age During 2 Influenza Seasons A Case-Cohort Study Peter G. Szilagyi, MD, MPH; Gerry Fairbrother, PhD; Marie R. Griffin, MD, MPH; Richard W. Hornung, DrPH; Stephanie Donauer, MS; Ardythe Morrow, PhD; Mekibib Altaye, PhD; Yuwei Zhu, MD, MS; Sandra Ambrose, MBA; Kathryn M. Edwards, MD; Katherine A. Poehling, MD, MPH; Geraldine Lofthus, PhD; Michol Holloway, MPH; Lyn Finelli, DrPH, MS; Marika Iwane, PhD, MPH; Mary Allen Staat, MD, MPH; for the New Vaccine Surveillance Network Objective: To measure vaccine effectiveness (VE) in pre- portional hazards models to estimate VE in preventing venting influenza-related health care visits among chil- inpatient/ED and outpatient visits. dren aged 6 to 59 months during 2 consecutive influ- enza seasons. Results: During the 2003-2004 and 2004-2005 sea- sons, 165 and 80 inpatient/ED and 74 and 95 outpatient Design: Case-cohort study estimating effectiveness of in- influenza cases were enrolled, while more than 4500 in- activated influenza vaccine in preventing inpatient/ patient/ED and more than 600 outpatient subcohorts were outpatient visits (emergency department [ED] and outpa- evaluated, respectively. In bivariate analyses, cases had tient clinic). We compared vaccination status of laboratory- lower vaccination rates than subcohorts.
JAMA Pediatrics – American Medical Association
Published: Oct 1, 2008
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