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Influence of Serotonin On Cerebral Circulation

Influence of Serotonin On Cerebral Circulation Abstract It is known that the flow of blood through an extremity is decreased by injection of serotonin (5-hydroxytryptamine [5-HT]) into its arterial blood supply.10,12,14 This is assumed to be due to narrowing caused by spasm of the vascular conduits. Serotonin also causes marked aggregation of platelets, leukocytes, and erythrocytes both in vitro and in vivo.17 This has been observed in vivo to be accompanied by a marked slowing of the circulation in the conjunctival blood vessels and, after repeated injections of serotonin, by significant reductions in the hematocrit. These changes could be due to, or contributed to by, microembolism of the smaller blood vessels by aggregated blood cells which remain sequestered in the capillary beds. In the present paper this problem is explored, and the response of the cerebral circulation to intravascular injections of serotonin is reported. Material and Methods Adult mongrel dogs weighing 14.6 ± 3.2 kg were References 1. Bouton, S. M., Jr.: Cerebral Air Embolism and Vital Staining: Contribution to Experimental Study of Blood-Brain Barrier , Arch Neurol Psychiat 43:1151, 1940.Crossref 2. Broman, T.: Permeability of Cerebrospinal Vessels in Normal and Pathological Conditions , Copenhagen: Ejnar Munksgaard, 1949. 3. de la Torre, E.; Netsky, M. G.; and Meschan, I.: Intracranial and Extracranial Circulations in Dog: Anatomic and Angiographic Studies , Amer J Anat 105:343-382, 1959.Crossref 4. Frohwein, R. A., et al: Sauerstoffverbrauch, Durchblutung und Vulnerabilität des Warmblüterhirns unter Megaphen (Chloropromazin) , Arch Exp Path Pharmacol 226:62-68, 1955. 5. Grontoft, O.: Intracranial Hemorrhage and Blood-Brain Barrier Problems in Newborn , Acta Path Microbiol Scand (suppl 100) , pp 1-109, 1954. 6. Hinshaw, D. B., et al: Regional Blood Flow in Hemorrhagic Shock , Amer J Surg 102:224, 1961.Crossref 7. Hirsch, H., et al: Screen Filtration Pressure of Homologous and Heterologous Blood and Electroencephalogram , Amer J Physiol , to be published. 8. Lee, J. C., and Olszewski, J.: Effect of Air Embolism on Permeability of Cerebral Blood Vessels , Neurology 9:619-625, 1959.Crossref 9. Noell, W., and Schneider, M.: Quantitative Angaben über Durchblutung und Sauerstoffversorgung des Gehirnes Pflueger Arch Ges Physiol 250:35, 1948.Crossref 10. Page, I. H.: Vascular Action of Natural Serotonin, 5- and 7-Hydroxytryptamine and Tryptamine , J Pharmacol Exp Ther 105:58-73, 1952. 11. Page, W. R.; German, W. J.; and Nims, L. F.: Nitrous Oxide Method for Measurements of Cerebral Blood Flow and Cerebral Gaseous Metabolism in Dogs , Yale J Biol Med 23:462-473, 1951. 12. Reid, G.: Circulatory Effects of 5-Hydroxytryptamine , J Physiol 118:435-453, 1952. 13. Reid, G., and Rand, M.: Pharmacological Action of 5-Hydroxytryptamine (Serotonin, Thrombocytin) , Nature (London) 169:801-802, 1952.Crossref 14. Roddie, I. C.; Sheperd, J. T.; and Whelan, R. F.: Action of 5-Hydroxytryptamine on Blood Vessels of Human Hand and Forearm , Brit J Pharmacol 10:445, 1955. 15. Swank, R. L., and Hain, R. F.: Effect of Different Sized Emboli on Vascular System and Parenchyma of Brain , J Neuropath Exp Neurol 11:280-299, 1952.Crossref 16. Swank, R. L., et al: Effect of Glass Wool Filtration on Blood During Extracorporeal Circulation , Surg Gynec Obstet 117:547-552, 1963. 17. Swank, R. L.; Fellman, J. H.; and Hissen, W. W.: Aggregation of Blood Cells by 5-Hydroxytryptamine (Serotonin) , Circ Res 13:392-400, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Influence of Serotonin On Cerebral Circulation

Archives of Neurology , Volume 10 (5) – May 1, 1964

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Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1964.00460170038006
Publisher site
See Article on Publisher Site

Abstract

Abstract It is known that the flow of blood through an extremity is decreased by injection of serotonin (5-hydroxytryptamine [5-HT]) into its arterial blood supply.10,12,14 This is assumed to be due to narrowing caused by spasm of the vascular conduits. Serotonin also causes marked aggregation of platelets, leukocytes, and erythrocytes both in vitro and in vivo.17 This has been observed in vivo to be accompanied by a marked slowing of the circulation in the conjunctival blood vessels and, after repeated injections of serotonin, by significant reductions in the hematocrit. These changes could be due to, or contributed to by, microembolism of the smaller blood vessels by aggregated blood cells which remain sequestered in the capillary beds. In the present paper this problem is explored, and the response of the cerebral circulation to intravascular injections of serotonin is reported. Material and Methods Adult mongrel dogs weighing 14.6 ± 3.2 kg were References 1. Bouton, S. M., Jr.: Cerebral Air Embolism and Vital Staining: Contribution to Experimental Study of Blood-Brain Barrier , Arch Neurol Psychiat 43:1151, 1940.Crossref 2. Broman, T.: Permeability of Cerebrospinal Vessels in Normal and Pathological Conditions , Copenhagen: Ejnar Munksgaard, 1949. 3. de la Torre, E.; Netsky, M. G.; and Meschan, I.: Intracranial and Extracranial Circulations in Dog: Anatomic and Angiographic Studies , Amer J Anat 105:343-382, 1959.Crossref 4. Frohwein, R. A., et al: Sauerstoffverbrauch, Durchblutung und Vulnerabilität des Warmblüterhirns unter Megaphen (Chloropromazin) , Arch Exp Path Pharmacol 226:62-68, 1955. 5. Grontoft, O.: Intracranial Hemorrhage and Blood-Brain Barrier Problems in Newborn , Acta Path Microbiol Scand (suppl 100) , pp 1-109, 1954. 6. Hinshaw, D. B., et al: Regional Blood Flow in Hemorrhagic Shock , Amer J Surg 102:224, 1961.Crossref 7. Hirsch, H., et al: Screen Filtration Pressure of Homologous and Heterologous Blood and Electroencephalogram , Amer J Physiol , to be published. 8. Lee, J. C., and Olszewski, J.: Effect of Air Embolism on Permeability of Cerebral Blood Vessels , Neurology 9:619-625, 1959.Crossref 9. Noell, W., and Schneider, M.: Quantitative Angaben über Durchblutung und Sauerstoffversorgung des Gehirnes Pflueger Arch Ges Physiol 250:35, 1948.Crossref 10. Page, I. H.: Vascular Action of Natural Serotonin, 5- and 7-Hydroxytryptamine and Tryptamine , J Pharmacol Exp Ther 105:58-73, 1952. 11. Page, W. R.; German, W. J.; and Nims, L. F.: Nitrous Oxide Method for Measurements of Cerebral Blood Flow and Cerebral Gaseous Metabolism in Dogs , Yale J Biol Med 23:462-473, 1951. 12. Reid, G.: Circulatory Effects of 5-Hydroxytryptamine , J Physiol 118:435-453, 1952. 13. Reid, G., and Rand, M.: Pharmacological Action of 5-Hydroxytryptamine (Serotonin, Thrombocytin) , Nature (London) 169:801-802, 1952.Crossref 14. Roddie, I. C.; Sheperd, J. T.; and Whelan, R. F.: Action of 5-Hydroxytryptamine on Blood Vessels of Human Hand and Forearm , Brit J Pharmacol 10:445, 1955. 15. Swank, R. L., and Hain, R. F.: Effect of Different Sized Emboli on Vascular System and Parenchyma of Brain , J Neuropath Exp Neurol 11:280-299, 1952.Crossref 16. Swank, R. L., et al: Effect of Glass Wool Filtration on Blood During Extracorporeal Circulation , Surg Gynec Obstet 117:547-552, 1963. 17. Swank, R. L.; Fellman, J. H.; and Hissen, W. W.: Aggregation of Blood Cells by 5-Hydroxytryptamine (Serotonin) , Circ Res 13:392-400, 1963.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: May 1, 1964

References

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