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- Publisher
- American Medical Association
- Copyright
- Copyright © 1952 American Medical Association. All Rights Reserved.
- ISSN
- 0096-6908
- DOI
- 10.1001/archsurg.1952.01260010803009
- Publisher site
- See Article on Publisher Site
Abstract
Abstract WHEN DOGS or rats are subjected to partial hepatectomy at repeated intervals, the remaining liver increases in bulk to replace the deficit. If one-fifth to three-fourths of a dog's liver is removed, the remaining part regenerates completely in from six to eight weeks. Similarly a rat liver will resume its previous size in 14 to 16 days following partial removal. It often happens that the restored liver weighs more than the original organ. According to Markowitz,1 the remaining part of the liver responds as rapidly and completely after the second or third partial hepatectomy as after the first. The cause of hepatic restoration may possibly be the relatively increased blood supply, since after operation blood from the portal vein and the hepatic artery traverses a smaller mass of tissue. In a paper on the relation of portal blood flow to liver maintenance, Rous and Larimore2 pointed out the References 1. Markowitz, J.: Experimental Surgery, Including Surgical Physiology , Ed. 2, Baltimore, Williams & Wilkins Company, 1949. 2. Rous, P., and Larimore, L. D.: Relation of the Portal Blood to Liver Maintenance: Demonstration of Liver Atrophy Conditional on Compensation , J. Exper. Med. 31:249 ( (May) ) 1920.Crossref 3. Mann, F. C.; Fishback, F. C.; Gay, J. G., and Green, G. F.: Experimental Pathology of the Liver , Arch. Path. 12:787 ( (Nov.) ) 1931. 4. Higgins, G. M., and Anderson, R. M.: Experimental Pathology of the Liver: Restoration of Liver of White Rat Following Partial Surgical Removal , Arch. Path. 12:186 ( (Aug.) ) 1931. 5. Good, C. A.; Kramer, H., and Somogyi, M.: The Determination of Glycogen , J. Biol. Chem. 100:485 ( (April) ) 1933. 6. Fenn, W. O., and Haege, L. F.: The Deposition of Glycogen with Water in the Livers of Cats , J. Biol. Chem. 136:87 ( (Oct.) ) 1940. 7. Wilson, W.: A Trichrome Method for Staining Fat with Oil Red O in Frozen Sections , Bull. Internat. A. M. Mus. No. (31) , p. 216, Nov. 1950.
Journal
A.M.A. Archives Surgery – American Medical Association
Published: Jun 1, 1952
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