Abstract WHEN DOGS or rats are subjected to partial hepatectomy at repeated intervals, the remaining liver increases in bulk to replace the deficit. If one-fifth to three-fourths of a dog's liver is removed, the remaining part regenerates completely in from six to eight weeks. Similarly a rat liver will resume its previous size in 14 to 16 days following partial removal. It often happens that the restored liver weighs more than the original organ. According to Markowitz,1 the remaining part of the liver responds as rapidly and completely after the second or third partial hepatectomy as after the first. The cause of hepatic restoration may possibly be the relatively increased blood supply, since after operation blood from the portal vein and the hepatic artery traverses a smaller mass of tissue. In a paper on the relation of portal blood flow to liver maintenance, Rous and Larimore2 pointed out the References 1. Markowitz, J.: Experimental Surgery, Including Surgical Physiology , Ed. 2, Baltimore, Williams & Wilkins Company, 1949. 2. Rous, P., and Larimore, L. D.: Relation of the Portal Blood to Liver Maintenance: Demonstration of Liver Atrophy Conditional on Compensation , J. Exper. Med. 31:249 ( (May) ) 1920.Crossref 3. Mann, F. C.; Fishback, F. C.; Gay, J. G., and Green, G. F.: Experimental Pathology of the Liver , Arch. Path. 12:787 ( (Nov.) ) 1931. 4. Higgins, G. M., and Anderson, R. M.: Experimental Pathology of the Liver: Restoration of Liver of White Rat Following Partial Surgical Removal , Arch. Path. 12:186 ( (Aug.) ) 1931. 5. Good, C. A.; Kramer, H., and Somogyi, M.: The Determination of Glycogen , J. Biol. Chem. 100:485 ( (April) ) 1933. 6. Fenn, W. O., and Haege, L. F.: The Deposition of Glycogen with Water in the Livers of Cats , J. Biol. Chem. 136:87 ( (Oct.) ) 1940. 7. Wilson, W.: A Trichrome Method for Staining Fat with Oil Red O in Frozen Sections , Bull. Internat. A. M. Mus. No. (31) , p. 216, Nov. 1950.
A.M.A. Archives Surgery – American Medical Association
Published: Jun 1, 1952
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera