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Influence of Estrogen Receptors on Survival and Recurrence in Patients With Breast Cancer Without Lymph Node Metastases

Influence of Estrogen Receptors on Survival and Recurrence in Patients With Breast Cancer Without... Abstract • A retrospective chart review was conducted to determine the prognostic effect of estrogen receptor (ER) protein in patients with node-negative operable breast cancer. One hundred nine patients with breast cancer whose tumors underwent ER analysis and whose lymph node negativity was established histologically were studied. Based on life-table analysis, the overall survival at six years was 92.7% for ER-positive patients, 95.3% for ER-negative patients, and 94.4% for ER-borderline patients. The disease-free survival was 83.3%, 92.8%, and 71.4%, respectively. Survival and diseasefree survival were also correlated to menopausal status. The difference in survival was not statistically significant at six years. We conclude that in node-negative primary operable breast cancer, ER status should not be used as a discriminant for adjuvant treatment. (Arch Surg 1989;124:377-380) References 1. McGuire WL: Current status of estrogen receptors in human breast cancer . Cancer 1975;36:638-644.Crossref 2. Walt AJ, Singhakowinta A, Brooks SC, et al: The surgical implications of estrophile protein estimations in carcinoma of the breast . Surgery 1976;80:506-512. 3. Knight WA, Livingston RB, Gregory EJ, et al: Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer . Cancer Res 1977;37:4669-4671. 4. Allegra JC, Lippman ME, Simon R, et al: Association between steroid hormone receptor status and disease-free interval in breast cancer . Cancer Treat Rep 1979;63:1271-1277. 5. Furmanski P, Saunders DE, Brooks SC, et al: The prognostic value of estrogen receptor determinations in patients with primary breast cancer: An update . Cancer 1980;46:2794-2796.Crossref 6. Rich MA, Furmanski P, Brooks SC, et al: Prognostic value of estrogen receptor determinations in patients with breast cancer . Cancer Res 1978;38:4296-4298. 7. Cooke T, Shields R, George D, et al: Estrogen receptors and prognosis in early breast cancer . Lancet 1979;1:995-997.Crossref 8. Gapinski PV, Donegan WL: Estrogen receptors and breast cancer: Prognostic and therapeutic implications . Surgery 1980;88:386-392. 9. Osborne CK, Yochomowitz MG, Knight WA, et al: The value of estrogen and progesterone receptors in the treatment of breast cancer . Cancer 1980;46:2884-2888.Crossref 10. Singhakowinta A, Saunders DE, Brooks SC, et al: Clinical applications of estrogen receptor in breast cancer . Cancer 1980;46:2932-2938.Crossref 11. Neifeld JP, Lawrence W, Brown PW, et al: Estrogen receptors in primary breast cancer . Arch Surg 1982;117:753-757.Crossref 12. Hilf R, Feldstein ML, Gibson SL, et al: The relative importance of estrogen receptor analysis as a prognostic factor for recurrence or response to chemotherapy in women with breast cancer . Cancer 1980;45:1993-2000.Crossref 13. Aamdal S, Bormer O, Jorgensen O, et al: Estrogen receptors and long-term prognosis in breast cancer . Cancer 1984;53:2525-2529.Crossref 14. Shapiro CM, Schifeling D, Bitran JD, et al: Prognostic value of the estrogen receptor level in pathologic stage I and II adenocarcinoma of the breast . J Surg Oncol 1982;19:119-121.Crossref 15. Butler JA, Bretsky S, Menendex-Botet C, et al: Estrogen receptor protein of breast cancer as a predictor of recurrence . Cancer 1985;55:1178-1181.Crossref 16. Liskowski L, Rose DP: Experience with a simple method for estrogen receptor assay in breast cancer . Clin Chim Acta 1976;67:175-182.Crossref 17. Hoehn JL, Plotka ED, Dickson KB: Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast . Ann Surg 1979;190:69-71.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Influence of Estrogen Receptors on Survival and Recurrence in Patients With Breast Cancer Without Lymph Node Metastases

Archives of Surgery , Volume 124 (3) – Mar 1, 1989

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1989.01410030127021
Publisher site
See Article on Publisher Site

Abstract

Abstract • A retrospective chart review was conducted to determine the prognostic effect of estrogen receptor (ER) protein in patients with node-negative operable breast cancer. One hundred nine patients with breast cancer whose tumors underwent ER analysis and whose lymph node negativity was established histologically were studied. Based on life-table analysis, the overall survival at six years was 92.7% for ER-positive patients, 95.3% for ER-negative patients, and 94.4% for ER-borderline patients. The disease-free survival was 83.3%, 92.8%, and 71.4%, respectively. Survival and diseasefree survival were also correlated to menopausal status. The difference in survival was not statistically significant at six years. We conclude that in node-negative primary operable breast cancer, ER status should not be used as a discriminant for adjuvant treatment. (Arch Surg 1989;124:377-380) References 1. McGuire WL: Current status of estrogen receptors in human breast cancer . Cancer 1975;36:638-644.Crossref 2. Walt AJ, Singhakowinta A, Brooks SC, et al: The surgical implications of estrophile protein estimations in carcinoma of the breast . Surgery 1976;80:506-512. 3. Knight WA, Livingston RB, Gregory EJ, et al: Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer . Cancer Res 1977;37:4669-4671. 4. Allegra JC, Lippman ME, Simon R, et al: Association between steroid hormone receptor status and disease-free interval in breast cancer . Cancer Treat Rep 1979;63:1271-1277. 5. Furmanski P, Saunders DE, Brooks SC, et al: The prognostic value of estrogen receptor determinations in patients with primary breast cancer: An update . Cancer 1980;46:2794-2796.Crossref 6. Rich MA, Furmanski P, Brooks SC, et al: Prognostic value of estrogen receptor determinations in patients with breast cancer . Cancer Res 1978;38:4296-4298. 7. Cooke T, Shields R, George D, et al: Estrogen receptors and prognosis in early breast cancer . Lancet 1979;1:995-997.Crossref 8. Gapinski PV, Donegan WL: Estrogen receptors and breast cancer: Prognostic and therapeutic implications . Surgery 1980;88:386-392. 9. Osborne CK, Yochomowitz MG, Knight WA, et al: The value of estrogen and progesterone receptors in the treatment of breast cancer . Cancer 1980;46:2884-2888.Crossref 10. Singhakowinta A, Saunders DE, Brooks SC, et al: Clinical applications of estrogen receptor in breast cancer . Cancer 1980;46:2932-2938.Crossref 11. Neifeld JP, Lawrence W, Brown PW, et al: Estrogen receptors in primary breast cancer . Arch Surg 1982;117:753-757.Crossref 12. Hilf R, Feldstein ML, Gibson SL, et al: The relative importance of estrogen receptor analysis as a prognostic factor for recurrence or response to chemotherapy in women with breast cancer . Cancer 1980;45:1993-2000.Crossref 13. Aamdal S, Bormer O, Jorgensen O, et al: Estrogen receptors and long-term prognosis in breast cancer . Cancer 1984;53:2525-2529.Crossref 14. Shapiro CM, Schifeling D, Bitran JD, et al: Prognostic value of the estrogen receptor level in pathologic stage I and II adenocarcinoma of the breast . J Surg Oncol 1982;19:119-121.Crossref 15. Butler JA, Bretsky S, Menendex-Botet C, et al: Estrogen receptor protein of breast cancer as a predictor of recurrence . Cancer 1985;55:1178-1181.Crossref 16. Liskowski L, Rose DP: Experience with a simple method for estrogen receptor assay in breast cancer . Clin Chim Acta 1976;67:175-182.Crossref 17. Hoehn JL, Plotka ED, Dickson KB: Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast . Ann Surg 1979;190:69-71.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1989

References