Abstract • To assess the effect of corticosteroid on the establishment of experimentally induced keratomycoses, rabbits were injected subconjunctivally with triamcinolone acetonide on two successive days before inoculation with Candida albicans, Aspergillus fumigatus, or Fusarium solanae. Whereas isolate recovery rates declined steadily in normal control corneas, they remained stable over 15 days in corticosteroid-treated corneas. Clinically, inflammation was equivalent (A fumigatus and F solanae) or significantly less (C albicans; P = .001) until the 10th day. At 15 days, inflammation in corticosteroid-treated corneas was significantly worse in animals infected with A fumigatus (P = .003) or F solanae (P = .02). Inflammatory signs correlated inconsistently with isolate recovery. Pathogenicity of the infecting organism appears to be important in determining the degree to which corticosteroid is able to mask clinical signs of infection while enhancing fungal replication. References 1. O'Day DM. Studies in experimental keratomycosis . Curr Eye Res . 1985;4:243-252.Crossref 2. Forster RK, Rebell G. Animal model of Fusarium solani keratitis . Am J Ophthalmol . 1975;79:510-515. 3. Burda CA, Fisher E. The use of cortisone in establishing experimental fungal keratitis in rats . Am J Ophthalmol . 1959;48:330-335. 4. Schaffner A. Experimental basis for the clinical epidemiology of fungal infections: a review . Mycoses . 1989;32:499-515.Crossref 5. Polansky JR, Weinreb RN. Anti-inflammatory agents: steroids as anti-inflammatory agents . In: Sears ML, ed. Pharmacology of the Eye . New York, NY: Springer-Verlag NY Inc; 1984:459-538. 6. Ray WA, O'Day DM, Head WS, Robinson RD. Variability in isolate recovery rates from multiple and single breeds of outbred pigmented rabbits in an experimental model of Candida keratitis . Curr Eye Res . 1984;3:949-953.Crossref 7. O'Day DM, Ray WA, Robinson RD, Head WS, Savage AM. In vitro and in vivo susceptibility of Candida keratitis to topical polyenes . Invest Ophthalmol Vis Sci . 1987;28:874-880. 8. O'Day DM. Orally administered antifungal therapy for experimental keratomycosis . Trans Am Ophthalmol Soc . 1990;88:685-725. 9. O'Day DM, Robinson RD, Head WS. Efficacy of antifungal agents in the cornea, I: a comparative study . Invest Ophthalmol Vis Sci . 1983;24:1098-1102. 10. Ray WA, O'Day DM, Head WS, Robinson RD. Statistical analysis for experimental models of ocular disease: continuous response measures . Curr Eye Res . 1985;4:585-597.Crossref 11. Snedecor GW, Cochran WG. Statistical Methods . 7th ed. Ames: Iowa State University Press; 1980:215-237. 12. Colton T, ed. Statistics in Medicine . Boston, Mass: Little, Brown & Co Inc; 1974:219-228. 13. O'Day DM, Ray WA, Robinson RD, Head WS. Efficacy of antifungal agents in the cornea, II: influence of corticosteroids . Invest Ophthalmol Vis Sci . 1984;25:331-335. 14. Schlaegel TF. Nonspecific treatment of uveitis . Tasman W, Jaeger EA, eds. Duane's Clinical Ophthalmology . Philadelphia, Pa: JB Lippincott; 1989;4:chap 43. 15. Johns KJ, O'Day DM. Pharmacologic management of keratomycoses . Surv Ophthalmol . 1988;33:178-188.Crossref
Archives of Ophthalmology – American Medical Association
Published: Nov 1, 1991
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