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Inflammation and Diabetes

Inflammation and Diabetes α1-Antitrypsin inhibits inflammation, restores blood glucose to normal levels, and induces immune tolerance to beta islet cells in a type 1 diabetes mouse model (Koulmanda M et al. Proc Natl Acad Sci U S A. 2008;105[42]:16242-16247). Inflammation has been shown to be linked to insulin resistance and to defective insulin signaling in nonobese diabetic (NOD) mice. To see if countering inflammation might have beneficial effects, the researchers gave the animals α1-antitrypsin, an anti-inflammatory protein produced by the body that can induce long-term tolerance to allogenic islet cell transplants. The researchers found that giving α1-antitrypsin for 14 days halted autoimmune type inflammation in NOD mice, which developed tolerance to the transplanted islet cells. Successful application of therapies that restore blood glucose to normal levels in NOD mice have predictive value for humans and may warrant attention as being worthy of further clinical testing, the researchers said. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Inflammation and Diabetes

JAMA , Volume 300 (21) – Dec 3, 2008

Inflammation and Diabetes

Abstract

α1-Antitrypsin inhibits inflammation, restores blood glucose to normal levels, and induces immune tolerance to beta islet cells in a type 1 diabetes mouse model (Koulmanda M et al. Proc Natl Acad Sci U S A. 2008;105[42]:16242-16247). Inflammation has been shown to be linked to insulin resistance and to defective insulin signaling in nonobese diabetic (NOD) mice. To see if countering inflammation might have beneficial effects, the researchers gave the animals α1-antitrypsin, an...
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Publisher
American Medical Association
Copyright
Copyright © 2008 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2008.737
Publisher site
See Article on Publisher Site

Abstract

α1-Antitrypsin inhibits inflammation, restores blood glucose to normal levels, and induces immune tolerance to beta islet cells in a type 1 diabetes mouse model (Koulmanda M et al. Proc Natl Acad Sci U S A. 2008;105[42]:16242-16247). Inflammation has been shown to be linked to insulin resistance and to defective insulin signaling in nonobese diabetic (NOD) mice. To see if countering inflammation might have beneficial effects, the researchers gave the animals α1-antitrypsin, an anti-inflammatory protein produced by the body that can induce long-term tolerance to allogenic islet cell transplants. The researchers found that giving α1-antitrypsin for 14 days halted autoimmune type inflammation in NOD mice, which developed tolerance to the transplanted islet cells. Successful application of therapies that restore blood glucose to normal levels in NOD mice have predictive value for humans and may warrant attention as being worthy of further clinical testing, the researchers said.

Journal

JAMAAmerican Medical Association

Published: Dec 3, 2008

Keywords: diabetes mellitus,inflammation

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