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INFECTIOUS DISEASES: Fourteenth Annual Review of Significant Publications

INFECTIOUS DISEASES: Fourteenth Annual Review of Significant Publications Abstract THE GREAT DECLINE in the incidence of infectious diseases and in the death rate among patients with such diseases in the past fifty years is an obvious fact. In a calculation of the mortality rate among policy holders of a large life insurance company,1 new low rates in 1947 are reported for whooping cough, diphtheria, influenza, pneumonia, tuberculosis, syphilis and appendicitis. For pneumonia alone the death rate has declined 70 per cent since 1937, when chemotherapy, soon followed by antibiotic therapy, began to be used generally. There is nothing at present which threatens to stem the downward trend to what eventually will be an irreducible minimum. According to Gordon,2 who discusses the influence of disease in war, the ratio of death from disease to deaths in battle gradually and irregularly declined from 7:1 in the Mexican War of 1846 to 0.4:1 in World War I to 0.01:1 in the last war. References 1. Mortality Decline to New Low in 1947 , Statist. Bull. Metrop. Life Insur. Co. 29:1-4 ( (Jan.) ) 1948. 2. Gordon, J. E.: The Strategic and Tactical Influence of Disease in World War II , Am. J. M. Sc. 215:311-326 ( (March) ) 1948.Crossref 3. Ingraham, H. S.: Recent Advances in Communicable Disease Control , New York State J. Med. 48:1135-1141 ( (May 15) ) 1948. 4. Exotic Disease, editorial , J.A.M.A. 136:111-112 ( (Jan. 10) ) 1948. 5. Eagle, H.: Speculation as to the Therapeutic Significance of the Penicillin Blood Level , Ann. Int. Med. 28:260-278 ( (Feb.) ) 1948.Crossref 6. Schachter, R. J.: Fate and Distribution of Penicillin in the Body: I. Circulation of Penicillin in the Lymph , Proc. Soc. Exper. Biol. & Med. 68:29-34 ( (May) ) 1948. 7. Price, A. H.: Aqueous Penicillin Therapy for Pneumococcic Pneumonia: Injection at Twelve Hour Intervals , J.A.M.A. 138:292-293 ( (Sept. 25) ) 1948. 8. White, H. J.; Baker, M. J., and Jackson, E. R.: Therapeutic Effectiveness of Single and Divided Doses of Penicillin in a Streptococcal Infection in Mice , Proc. Soc. Exper. Biol. & Med. 67:199-203 ( (Feb.) ) 1948. 9. Sloan, J. Q.; Bain, G. P., and Brucer, M.: Depth of Penetration of Nebulized Substances in the Respiratory Tree , Proc. Soc. Exper. Biol. & Med. 66:264-267 ( (Oct.) ) 1947. 10. Laurant, A. M.; McIlroy, A. P., and Hadley, F. P.: Penicillin and Streptomycin in the Lungs and Blood Serum of Rats Following Inhalational and Intramuscular Administration , Proc. Soc. Exper. Biol. & Med. 68:213-216 ( (May) ) 1948. 11. Procaine-Penicillin G (Duracillin): A New Salt of Penicillin Which Prolongs the Action of Penicillin , Proc. Staff Meet., Mayo Clin. 22:567-570 ( (Dec. 10) ) 1947. 12. Sullivan, N. P.; Symmes, A. T.; Miller, H. C., and Rhodehamel, H. W., Jr.: A New Penicillin for Prolonged Blood Levels , Science 107:169-170 ( (Feb. 13) ) 1948. 13. Hobby, G. L.; Brown, E., and Patelski, R. A.: Biological Activity of Crystalline Procaine Penicillin in Vitro and in Vivo , Proc. Soc. Exper. Biol. & Med. 67:6-14 ( (Jan.) ) 1948. 14. Hagedorn, A. B., and Scheifley, C. H.: Subacute Bacterial Endocarditis: A Case Report , Proc. Staff Meet., Mayo Clin. 23:14-16 ( (Jan. 7) ) 1948. 15. Barber, M.: Staphylococcal Infection Due to Penicillin-Resistant Strains , Brit. M. J. 2:863-865 ( (Nov. 29) ) 1947. 16. Vander Veer, J. B., and Richardson, F. M.: Penicillin Plus Caronamide in the Treatment of Subacute Bacterial Endocarditis , Tr. & Stud., Coll. Physicians, Philadelphia 15:109-112 ( (Dec.) ) 1947. 17. Miller, C. P.; Hawk, W. D.; and Boore, A. K.: Protection Against Bacterial Endotoxins by Penicillin and Its Impurities , Science 107:118-119 ( (Jan. 30) ) 1948. 18. Hunnicutt, T.; Graf, W. J.; Hamburger, M.; Ferris, E. B., and Scheinker, I. M.: Fatal Toxic Encephalopathy Apparently Caused by Streptomycin , J.A.M.A. 137:599-602 ( (June 12) ) 1948. 19. Rosen, F. L.: Sensitivity to Streptomycin: Anaphylactic Shock with Recovery Following an Intracutaneous Test , J.A.M.A. 137:1128 ( (July 24) ) 1948. 20. Kushnick, T.; Randles, C. I.; Gray, C. T., and Birkeland, J. M.: Variants of Escherichia Coli, Pseudomonas Aeruginosa and Bacillus Subtilis Requiring Streptomycin , Science 106:587-588 ( (Dec. 12) ) 1947. 21. Paine, T. F., and Finland, M.: Streptomycin-Sensitive, -Dependent and -Resistant Bacteria , Science 107:143-144 ( (Feb. 6) ) 1948.Crossref 22. Florey, H.: New Antibiotic Agents , J.A.M.A. 135:1047-1049 ( (Dec. 20) ) 1947.Crossref 23. Schoenbach, E. B.; Bryer, M. S.; Bliss, E. A., and Long, P. H.: Polymyxin: A Note on Experimental and Clinical Investigation , J.A.M.A. 136:1096-1098 ( (April 24) ) 1948.Crossref 24. Brownlee, G., and Bushby, S. R. M.: Chemotherapy and Pharmacology of Aerosporin: Selective Gram-Negative Antibiotic , Lancet 1:127-133 ( (Jan. 24) ) 1948.Crossref 25. Swift, P. N.: Treatment of Pertussis with Aerosporin , Lancet 1:133-134 ( (Jan. 24) ) 1948.Crossref 26. Ehrlich, J.; Bartz, Q. R.; Smith, R. M., and Joslyn, D. A.: Chloromycetin, a New Antibiotic from a Soil Actinomycete , Science 106:417 ( (Oct. 31) ) 1947.Crossref 27. Smadel, J. E., and Jackson, E. B.: Chloromycetin, an Antibiotic with Chemotherapeutic Activity in Experimental Rickettsial and Viral Infections , Science 106:418-419 ( (Oct. 31) ) 1947.Crossref 28. Smadel, J. E.; Woodward, T. E.; Levy, H. L., Jr.; Philip, C. B., and Traub, R.: Chloromycetin in the Treatment of Scrub Typhus , Science 108:160-161 ( (Aug. 13) ) 1948.Crossref 29. Woodward, T. E.; Smadel, J. E.; Ley, H. L., Jr.; Green, R., and Mankikar, D. S.: Effect of Chloromycetin in the Treatment of Typhoid Fever , Ann. Int. Med. 29:131-134 ( (July) ) 1948.Crossref 30. Finland, M.; Collins, H. S., and Paine, T. F.: Aureomycin, a New Antibiotic: Results of Laboratory Studies and of Clinical Use in Cases of Bacterial Infections , J.A.M.A. 138:946-949 ( (Nov. 27) ) 1948.Crossref 31. Collins, H. S.; Paine, T. F., and Finland, M.: Aureomycin in Treatment of Pneumonia and Meningococcemia , Proc. Soc. Exper. Biol. & Med. 69: 263-265 ( (Nov.) ) 1948. 32. Hirschhorn, H. N.; Bucca, M. A., and Thayer, J. D.: Subtenolin: An Antibiotic from Bacillus Subtilis; I. Bacteriologic Properties , Proc. Soc. Exper. Biol. & Med. 67:429-432 ( (April) ) 1948. 33. Landy, M.; Warren, G. H.; Rosenmann, S. B., and Colio, L. G.: Bacillomycin: An Antibiotic from Bacillus Subtilis Active Against Pathogenic Fungi , Proc. Soc. Exper. Biol. & Med. 67:539-541 ( (April) ) 1948. 34. Cost of the Common Cold , Statist. Bull. Metrop. Life Insur. Co. 28:6-7 ( (Nov.) ) 1947. 35. Clinical Patterns of Undifferentiated and Other Acute Respiratory Diseases in Army Recruits, Commission on Acute Respiratory Diseases , Medicine 26:441-464 ( (Dec.) ) 1947. 36. Bacteriological Findings in Undifferentiated and Other Acute Respiratory Diseases, Commission on Acute Respiratory Diseases , Medicine 26:465-484 ( (Dec.) ) 1947. 37. Dingle, H. H.: Experimental Studies of the "Common Cold" in Human Volunteers , Tr. & Stud., Coll. Physicians, Philadelphia 15:113-123 ( (Dec.) ) 1947. 38. Research on the Common Cold, Foreign Letters , J.A.M.A. 136:277 ( (Jan. 24) ) 1948. 39. Topping, N. H., and Atlas, L. T.: The Common Cold: A Note Regarding Isolation of an Agent Science 106:636-637 ( (Dec. 26) ) 1947. 40. Calvy, G. L.: Appendicitis and Upper Respiratory Infection: A Report of Eighteen Cases at Sea , Ann. Int. Med. 28:998-1002 ( (May) ) 1948. 41. Gustafsen, W. E.: Preliminary Studies on the Agent of Canine Pharyngo-Laryngo-Tracheitis , Yale J. Biol. & Med. 20:185-196 ( (Dec.) ) 1947. 42. Collen, M. F., and Dobson, R. L.: Clinical Evaluation of the Treatment of Pneumococcic Type III Pneumonia , Am. J. Med. 4:383-389 ( (March) ) 1948. 43. Israel, H. L.; Mitterling, R. C., and Flippin, H. L.: Pneumonia at the Philadelphia General Hospital, 1936-1946 , New England J. Med. 238:205-212 ( (Feb. 12) ) 1948. 44. Treatment of Pneumonia, Conference on Therapy , Am. J. Med. 4:423-435 ( (March) ) 1948. 45. Horsfall, F. L.: Primary Atypical Pneumonia and Influenza , Bull. New York Acad. Med. 24:431-446 ( (July) ) 1948. 46. Parker, F.; Jolliffe, L. S., and Finland, M.: Primary Atypical Pneumonia: Report of Eight Cases with Autopsies , Arch. Path. 44:581-608 ( (Dec.) ) 1947. 47. Davis, D. J.: Susceptibility of the English Sparrow (Passer Domesticus) to Infection with Psittacosis Virus of Pigeon Origin , Proc. Soc. Exper. Biol. & Med. 66:77-79 ( (Oct.) ) 1947. 48. Scadding, J. G.: The Pneumonias Associated with Epidemic Respiratory Infections , Lancet 1:89-93 ( (Jan. 17) ) 1948. 49. Finland, M.; Jolliffe, L. S., and Parker, F.: Pneumonia and Erythema Multiforme Exudativum , Am. J. Med. 4:473-492 ( (April) ) 1948. 50. Knutsen, B.: Primary Atypical Pneumonia , Norsk. mag. f. lægevidensk. 36:2099-2105 ( (Oct. 17) ) 1947. 51. Cain, J. C.; Devins, E. J., and Downing, J. E.: An Unusual Pulmonary Disease , Arch. Int. Med. 79:626-641 ( (June) ) 1947. 52. Stephens, J. W.: Primary Atypical Pneumonia , Lancet 1:703-707 ( (May 8) ) 1948. 53. Gasser, C.: Wassermann-Positive Bronchopneumonia During Childhood and Its Various Manifestations (Fanconi-Hegglin Syndrome): Contribution to Aspects of Miliary Bronchopneumonia and Virus Pneumonia , Helveti. pædiat. acta 2:185-226 ( (June) ) 1947. 54. Finland, M.; Barnes, M. W.; Meads, M., and Ory, E. M.: Serologic Studies of Influenza Made in Boston During the Winter of 1945-1946 , J. Lab. & Clin. Med. 33:15-31 ( (Jan.) ) 1948. 55. Barnes, M. W.; Morgan, H. R., and Finland, M.: Isolation and Identification of Influenza Viruses During Epidemic of December, 1945 , J. Lab. & Clin. Med. 33:309-318 ( (March) ) 1948. 56. Finland, M.; Ory, E. M.; Meads, M., and Barnes, M. W.: Influenza and Pneumonia: Serologic Studies During and After an Outbreak of Influenza B , J. Lab. & Clin. Med. 33:32-46 ( (Jan.) ) 1948. 57. Van Ravenswaay, A. C.: Prophylactic Use of Influenza Vaccine: An Instance of Inadequate Protection Against Influenza A , J.A.M.A. 136:435-437 ( (Feb. 14) ) 1948. 58. Sigel, M. M.; Shaffer, F. W.; Wiener Kirber, M.; Light, A. B., and Henle, W.: Influenza A in a Vaccinated Population , J.A.M.A. 136:437-441 ( (Feb. 14) ) 1948. 59. Sartwell, P. E., and Long, A. P.: The Army Experience with Influenza, 1946-1947: I. Epidemiological Aspects , Am. J. Hyg. 47:135-141 ( (March) ) 1948. 60. Kalter, S. S.; Chapman, O. D.; Feeley, D. A., and MacDowell, S. L.: An Epidemic of Influenza Due to an Atypical Strain: The Relationship of This Strain to Other Influenza Viruses , J. Immunol. 59:147-157 ( (June) ) 1948. 61. Rasmussen, A. F.; Stokes, J. C., and Smadel, J. E.: The Army Experience with Influenza, 1946-1947: II. Laboratory Aspects , Am. J. Hyg. 47:142-149 ( (March) ) 1947. 62. Hirst, G. K.: Studies on the Mechanism of Adaptation of Influenza Virus to Mice , J. Exper. Med. 86:357-366 ( (Nov.) ) 1947.Crossref 63. Hirst, G. K.: Comparisons of Influenza Virus Strains from Three Epidemics , J. Exper. Med. 86:367-381 ( (Nov.) ) 1947.Crossref 64. Magill, T. P., and Sugg, J. Y.: The Reversibility of the O-D Type of Influenza Virus Variation , J. Exper. Med. 87:535-546 ( (June) ) 1948.Crossref 65. Center for Study of Influenza Virus Strains Established, Current Comment , J.A.M.A. 135:1156 ( (Dec. 27) ) 1947. 66. Weller, T. H.; Cheever, F. S., and Enders, J. F.: Immunologic Reactions Following the Intradermal Inoculation of Influenza A and B Vaccine , Proc. Soc. Exper. Biol. & Med. 67:96-101 ( (Jan.) ) 1948. 67. Hoyle, L., and Fairbrother, R. W.: Serologic Diagnosis of Epidemic Influenza by Complement-Fixation Reaction , Brit. M. J. 2:991-993 ( (Dec. 20) ) 1947. 68. Enders, J. F.: A Review of Some Recently Defined Virus Diseases , New England J. Med. 237:897-900 ( (Dec. 11) ) 1947. 69. Cutting, W. C., and others: Chemotherapy of Virus Infections , J. Immunol. 57:379-390 ( (Dec.) ) 1947. 70. Rivers, T. M.: Recent Advances in the Treatment of Viral and Rickettsial Diseases , J.A.M.A. 136:291-292 ( (Jan. 31) ) 1948. 71. Radioactive Virus, editorial , J.A.M.A. 136:473 ( (Feb. 4) ) 1948. 72. Gordon, F. F., and others: Recovery of Poliomyelitis Virus from the Throat During the Incubation Period , J.A.M.A. 135:884-888 ( (Dec. 6) ) 1947. 73. Brown, G. C.; Francis, T., and Ainslie, J.: Studies of the Distribution of Poliomyelitis Virus: V. The Virus in Familial Associates of Cases , J. Exper. Med. 87:21-27 ( (Jan.) ) 1948. 74. Wenner, H. A., and Tanner, W. A.: Widespread Distribution of Poliomyelitis in Households Attacked by the Disease , Proc. Soc. Exper. Biol. & Med. 66:92-95 ( (Oct.) ) 1947. 75. Sweetnam, W. P.: Epidemiology of the 1947 Outbreak of Poliomyelitis in Eccles , Brit. M. J. 1:1172-1175 ( (June 19) ) 1948. 76. Dixon, G. J.: The Oecology of Poliomyelitis in a Military Camp in 1947 , Brit. M. J. 1:1175-1178 ( (June 19) ) 1948. 77. Loring, H. S.; Raffel, S., and Anderson, J. C.: Complement-Fixation in Experimental and Human Poliomyelitis , Proc. Soc. Exper. Biol. & Med. 66:385-392 ( (Nov.) ) 1947. 78. Gallan, F., and Marvin, J. F.: Electron-Microscopy of the Purified MM Poliomyelitis Virus , Proc. Soc. Exper. Biol. & Med. 67:366-367 ( (March) ) 1948. 79. Dalldorf, G., and Sickles, G. M.: An Unidentified, Filtrable Agent Isolated from the Feces of Children with Paralysis , Science 108:61-62 ( (July 16) ) 1948. 80. Cunning, D. S.: Tonsillectomy and Poliomyelitis , Arch. Otolaryng. 46: 575-583 ( (Nov.) ) 1947. 81. Swan, C.: Rubella in Pregnancy as an Aetiological Factor in Stillbirth , Lancet 1:744-746 ( (May 15) ) 1948.Crossref 82. Hamburger, V., and Habel, K.: Teratogenic and Lethal Effects of Influenza-A and Mumps Viruses in Early Chick Embryos , Proc. Soc. Exper. Biol. & Med. 66:608-617 ( (Dec.) ) 1947. 83. Fox, M. K.; Krumbiegel, E. R., and Teresi, J. L.: Maternal Measels, Mumps and Chickenpox as a Cause of Congenital Anomalies , Lancet 1:746-749 ( (May 15) ) 1948. 84. Kipping, R. H., and Downie, A. W.: Generalized Infection with the Virus of Herpes Simplex , Brit. M. J. 1:247-249 ( (Feb. 7) ) 1948. 85. Ruchman, I.; Welsh, A. L., and Dodd, K.: Kaposi's Varicelliform Eruption: Isolation of Virus of Herpes Simplex from Cutaneous Lesions of Three Adults and One Infant , Arch. Dermat. & Syph. 56:846-863 ( (Dec.) ) 1947. 86. Good, R. A., and Campbell, B.: The Precipitation of Latent Herpes Simplex Encephalitis by Anaphylactic Shock , Proc. Soc. Exper. Biol. & Med. 68:82-87 ( (May) ) 1948. 87. Smith, C. S.: Smallpox in Staffordshire, 1947: Outbreak at Bilston , Brit. M. J. 1:139-142 ( (Jan. 24) ) 1948. 88. Duffy, C. E.; Woolley, P. V., Jr., and Nolting, W. S.: Rabies: A Case Report with Notes on the Isolation of the Virus from Saliva , J. Pediat. 31:440-447 ( (Oct.) ) 1947. 89. Sellers, T. F.: Rabies, the Physician's Dilemma , Am. J. Trop. Med. 28: 453-456 ( (May) ) 1948. 90. Johnson, H. N.: Derriengue: Vampire Bat Rabies in Mexico , Am. J. Hyg. 47:189-204 ( (March) ) 1948. 91. Brooksby, J. B.: Vesicular Stomatitis and Foot-and-Mouth Disease Differentiation by Complement-Fixation , Proc. Soc. Exper. Biol. & Med. 67:254-258 ( (Feb.) ) 1948. 92. Capps, R. B.; Sborov, V., and Scheiffley, C. S.: A Syringe-Transmitted Epidemic of Infectious Hepatitis , J.A.M.A. 136:819-824 ( (March 20) ) 1948. 93. Epidemic of Homologous Serum Jaundice, Foreign Letters , J.A.M.A. 136:209-210 ( (May 8) ) 1948. 94. Physicians Imprisoned for the Epidemic of Varese, Foreign Letters , J.A.M.A. 137:1077 ( (July 17) ) 1948. 95. Popper, H., and Franklin, M.: Diagnosis of Hepatitis by Histologic and Functional Laboratory Methods , J.A.M.A. 137:230-234 ( (May 15) ) 1948. 96. McMichael, J.: Disease of the Liver: A Review of Some Clinical and Biochemical Problems as Revealed by Systematic Biopsy Studies , J.A.M.A. 137: 234-236 ( (May 15) ) 1948. 97. Sherlock, S. P. V.: Aspiration Liver Biopsy: Technique and Diagnostic Application , Lancet 2:397-401 ( (Sept. 29) ) 1945. 98. Sherlock and Walshe, cited by McMichael.86 99. Kalk, H., and Büchner, F.: Bioptic Picture of Epidemic Hepatitis Laparoscopic and Microscopic Observations) , Klin. Wchnschr. 24-25:878-880 ( (Nov. 15) ) 1947. 100. Havens, W. P.; Gambescia, J. M., and Knowlton, M.: Results of Heterophile Antibody Agglutination and Kahn Tests in Patients with Viral Hepatitis , Proc. Soc. Exper. Biol. & Med. 67:437-440 ( (April) ) 1948. 101. Smillie, J. H.; Howitt, B. F., and Denison, G. A.: An Epidemic of Acute Watery Diarrhea in Alabama , Pub. Health Rep. 63:233-243 ( (Feb. 20) ) 1948. 102. Pond, M. A., and Hathaway, J. S.: An Epidemic of Mild Gastroenteritis of Unknown Etiology Presumably Spread by Contaminated Eating Utensils , Am. J. Pub. Health 37:1402-1406 ( (Nov.) ) 1946. 103. Perri, A. M.: Epidemic Nausea, Vomiting and Diarrhea , Philadelphia Med. 43:1125 ( (March 20) ) 1948. 104. Gordon, I.; Ingraham, H. S., and Korns, R. F.: Transmission of Epidemic Gastroenteritis to Human Volunteers by Oral Administration of Fecal Filtrates , J. Exper. Med. 86:409-422 ( (Nov.) ) 1947.Crossref 105. Christensen, E., and Biering-Sorensen, K.: Meningitis- and Encephalitis-like Changes in the Brain of Infants with Severe Gastroenteritis , Acta path. et microbiol. Scandinav. 23:395-406, 1946.Crossref 106. Smillie, Howitt and Denison.91 107. Enders.59 108. Clifford, S. H.: Diarrhea of the Newborn: Its Causes and Prevention , New England J. Med. 237:969-976 ( (Dec. 25) ) 1947.Crossref 109. Schmidt, E. C. H.: Virus Myocarditis: Pathologic and Experimental Studies , Am. J. Path. 24:97-108 ( (Jan.) ) 1948. 110. Warren, J., and Smadel, J. E.: A Serological Relationship Between the Virus of Encephalomyocarditis and Certain Strains of Poliomyelitis-Like Viruses , Federation Proc. 7:311-312 ( (March) ) 1948. 111. Melnick, J. L., and Paul, J. R.: Experimental Fort Bragg Fever (Pretibial Fever) in Chimpanzees , Proc. Soc. Exper. Biol. & Med. 67:263-269 ( (March) ) 1948. 112. Sprunt, D. H.: Increased Susceptibility of Mice to Swine Influenza as a Result of Methionine Injections , Proc. Soc. Exper. Biol. & Med. 67:319-321 ( (March) ) 1948. 113. DeLay, P. D.; DeOme, K. B., and Bankowski, R. A.: Recovery of Pneumoencephalitis (Newcastle) Virus from the Air of Poultry Houses Containing Infected Birds , Science 107:474-475 ( (May 7) ) 1948. 114. Evans, A. S., and Curnen, E. C.: Serological Studies on Infectious Mononucleosis and Other Conditions with Human Erythrocytes Modified by Newcastle Disease Virus , abstracted, Federation Proc. 7:304 ( (March) ) 1948. 115. Nagler, F. P., and Rake, G.: Use of Electron Microscope in Diagnosis of Varicella, Vaccina and Varicella , J. Bact. 55:45-60 ( (Jan.) ) 1948. 116. Volkert, M., and Horsfall, F. L.: Studies on a Lung Tissue Component Which Combines with Pneumonia Virus of Mice (P.V.M.) , J. Exper. Med. 86: 393-407 ( (Nov.) ) 1947. 117. Griffitts, J. J.: Hemagglutination by Bacterial Suspensions with Special Reference to Shigella Alkalescens , Proc. Soc. Exper. Biol. & Med. 67:358-362 ( (March) ) 1948. 118. Corper, H. J., and Cohn, M. L.: Various Phases of the Use of Streptomycin in Tuberculosis , J.A.M.A. 137:357-362 ( (May 22) ) 1948. 119. Pyle, M. M.: Relative Numbers of Resistant Tubercle Bacilli in Sputa of Patients Before and During Treatment with Streptomycin , Proc. Staff Meet., Mayo Clin. 22:465-473 ( (Oct. 15) ) 1947. 120. Oatway, W. H., Jr.: A Streptomycin Hazard to Public Health, Correspondence , J.A.M.A. 136:490 ( (Feb. 14) ) 1948. 121. Miller, J., and Rowley, D.: Recovery of Streptomycin from Urine , Lancet 1:404 ( (March 13) ) 1948. 122. Deyke, V. F., and Wallace, J. B.: Development of Aplastic Anemia During the Use of Streptomycin , J.A.M.A. 137:599-602 ( (June 12) ) 1948. 123. Freedlander, B. L., and French, F. A.: Chemotherapy of Experimental Tuberculosis with Benzothiazole Derivatives , Proc. Soc. Exper. Biol. & Med. 66:362-365 ( (Nov.) ) 1947. 124. Feldman, W. H.; Karlson, A. G., and Hinshaw, H. C.: Promin in Experimental Tuberculosis: Antituberculosis Effects of Sodium P,P'-Diaminodiphenylsulfone-N,N'-Didextrose Sulfonate (Promin) Administered Subcutaneously (A Preliminary Report) , Proc. Staff Meet., Mayo Clin. 23:118-123 ( (March) ) 1948. 125. Volkert, M.; Pierce, C.; Horsfall, F. L., Jr., and Dubos, R. J.: Enhancing Effect of Concurrent Infection with Pneumotrophic Viruses of Pulmonary Tuberculosis in Mice , J. Exper. Med. 86:203-214 ( (Sept.) ) 1947.Crossref 126. Ratcliffe, H. L., and Wells, W. F.: Tuberculosis of Rabbits Induced by Droplet Nuclei Infection: I. Initial Response to Infections , J. Exper. Med. 87: 575-584 ( (June) ) 1948Crossref 127. II. Response to Infection , Ratcliffe J. Exper. Med. 87:585-594 ( (June) ) 1948.Crossref 128. Compulsory BCG Vaccination, Foreign Letters , J.A.M.A. 136:642 ( (Feb. 28) ) 1948.Crossref 129. Malmros, H.: Late Primary Infection and BCG Vaccination , Am. Rev. Tuberc. 56:267-278 ( (Oct.) ) 1947. 130. Rosenthal, S. R.; Leslie, E. I., and Loewinsohn, E.: BCG Vaccination in All Age Groups , J.A.M.A. 136:73-79 ( (Jan. 10) ) 1948.Crossref 131. Wilson, G. S.: Value of B.C.G. Vaccination in Control of Tuberculosis , Brit. M. J. 2:855-858 ( (Nov. 29) ) 1947.Crossref 132. Wallgren, A.: B.C.G. Vaccination: Is It of Any Value in Control of Tuberculosis? Brit. M. J. 1:1126-1129 ( (June 12) ) 1948.Crossref 133. Malmros, H.: The Efficacy of B.C.G. Vaccination , Brit. M. J. 1:1129-1132 ( (June 12) ) 1948.Crossref 134. Aronson, G. D.: The Evaluation of BCG Vaccine in the Control of Tuberculosis , Tr. & Stud., Coll. Physicians, Philadelphia 16:1-13 ( (April) ) 1948. 135. Weber, F. W.: Further Study of BCG Vaccination, editorial , Pub. Health Rep. 63:593-594 ( (May 7) ) 1948. 136. McCoy, G. W.: Leprosy in California—Danger of Infection , Pub. Health Rep. 63:705-712 ( (May 28) ) 1948. 137. Aycock, W. L., and Gordon, J. E.: Leprosy in Veterans of American Wars , Am. J. M. Sc. 214:329-339 ( (Sept.) ) 1947. 138. Porritt, R. J., and Olsen, R. E.: Two Simultaneous Cases of Leprosy Developing in Tattoos , Am. J. Path. 23-805-818 ( (Sept.) ) 1947. 139. MacCallum, P., and others: A New Mycobacterial Infection in Man , J. Path. & Bact. 60:93-122 ( (Jan.) ) 1948. 140. Steele, J. H., and Hastings, J. W.: Report of Brucellosis Outbreak at Federalsburg, Maryland , Pub. Health Rep. 63:144-145 ( (Jan. 30) ) 1948. 141. Pulaski, E. J., and Amspacher, W. H.: Streptomycin Therapy in Brucellosis, Bull , U. S. Army M. Dept. 7:221-226 ( (Feb.) ) 1947. 142. Eisele, C. W., and McCullough, N. B.: Combined Streptomycin and Sulfadiazine Treatment in Brucellosis , J.A.M.A. 135:1053-1055 ( (Dec. 20) ) 1947. 143. Spink, W. W.; Hall, W. H.; Shaffer, J. M., and Brande, A. I.: Human Brucellosis: Its Specific Treatment with a Combination of Streptomycin and Sulfadiazine , J.A.M.A. 136:382-387 ( (Feb. 7) ) 1948. 144. Harris, H. J., and Jett, P. C.: Streptomycin and Sulfadiazine (Combined) in Chronic Brucellosis , J.A.M.A. 137:363-364 ( (May 22) ) 1948.Crossref 145. Spink, W. W.; Braude, A. I.; Casteneda, M. R., and Goytia, R. S.: Aureomycin Therapy in Human Brucellosis Due to Brucella Melitensis , J. A. M. A. 138:1145-1148 ( (Dec. 18) ) 1948.Crossref 146. Griggs, J. F.: Chronic Brucellosis: Conclusions on Treatment After Ten Years , J.A.M.A. 136:911-915 ( (April) ) 1948.Crossref 147. Eisele, C. W.; McCullough, N. B.; Beal, G. A., and Rottschaefer, W.: Brucella Agglutination Tests and Vaccination Against Cholera , J.A.M.A. 135:983-984 ( (Dec. 13) ) 1947.Crossref 148. Eisele, C. W.; McCullough, N. B., and Beal, G. A.: Brucella Antibodies Following Cholera Vaccination , Ann. Int. Med. 28:833-837 ( (April) ) 1948.Crossref 149. Harvey, W. A.: Pulmonary Brucellosis , Ann. Int. Med. 28:768-781 ( (April) ) 1948.Crossref 150. Ammundsen, E., and others: Types of Diphtheria Bacillus and Clinical Diphtheria , Acta med. Scandinav. 129:415-440, 1948.Crossref 151. Jenkins, A. A.: Diphtheria Epidemic in Utah in 1947 , Pub. Health Rep. 63:573-577 ( (April 30) ) 1948.Crossref 152. Galbraith, T. W.: Appearance of "Minimus" Type Diphtheria in Utah , Pub. Health Rep. 63:577-579 ( (April 30) ) 1948.Crossref 153. Bost, R. B.; Percefull, S. C., and Leming, H. E.: Tularemia in the Ozarks Region , J.A.M.A. 137:352-354 ( (May 22) ) 1948.Crossref 154. Foshay, L.: Streptomycin in Treatment of Tularemia , J. Indiana M.A. 41:207-210 ( (Feb.) ) 1948. 155. Tieh, T. H.; Landauer, E.; Miyagawa, F.; Kobayaschi, I., and Okayasu, G.: Primary Pneumonic Plague in Mukden 1946, and Report of Thirty-Nine Cases with Three Recoveries , J. Infect. Dis. 82:52-58 ( (Jan.-Feb.) ) 1948.Crossref 156. Plague in Brazil, Foreign Letters , J.A.M.A. 136:710 ( (March 6) ) 1948. 157. Wynne-Griffith, G.: Pneumonic Plague in Rangoon , Lancet 1:625-627 ( (April 24) ) 1948.Crossref 158. Huang, C. H.; Huang, C. Y.; Chu, L. W., and Huang, T. F.: Pneumonic Plague: A Report of Recovery in a Proved Case and a Note on Sulfadiazine Prophylaxis , Am. J. Trop. Med. 28:361-371 ( (May) ) 1948. 159. Quan, S. F.; Foster, L. E.; Larson, A., and Meyer, K. F.: Streptomycin in Experimental Plague , Proc. Soc. Exper. Biol. & Med. 66:528-532 ( (Dec.) ) 1947. 160. Karamchandi, P. V., and Sundar Rao, K.: Streptomycin in Human Plague , Lancet 1:22 ( (Jan. 3) ) 1948. 161. Hall, W. W.: The U. S. Navy's War Record with Tetanus Toxoid , Ann. Int. Med. 28:298-308 ( (Feb.) ) 1948. 162. Shanahan, R. H.; Griffin, J. R., and Auersperg, A. P.: Anthrax Meningitis: Report of a Case of Internal Anthrax with Recovery , Am. J. Clin. Path. 17:719-721 ( (Sept.) ) 1947. 163. Anthrax in Elephants, Queries and Minor Notes , J.A.M.A. 135:1042 ( (Dec. 13) ) 1947. 164. Seideman, R. M., and Whaler, K. M.: Elephant Tusks: A Source of Human Anthrax , J.A.M.A. 135:837-838 ( (Nov. 29) ) 1947.Crossref 165. Devine, K. D.; Weed, L. A.; Nichols, D. R., and New, G. B.: Rhinoscleroma Apparently Cured with Streptomycin , Proc. Staff Meet., Mayo Clin. 22:597-600 ( (Dec. 24) ) 1947. 166. Weil, A. J., and Binder, M.: Experimental Type Transformation of Shigella Paradysenteriae (Flexner) , Proc. Soc. Exper. Biol. & Med. 66:349-352 ( (Nov.) ) 1947. 167. Edwards, P. R.; Moran, A. B., and Bruner, D. W.: Intertransformability of Salmonella Simsbury and Salmonella Senftenberg , Proc. Soc. Exper. Biol. & Med. 66:230-232 ( (Oct.) ) 1947. 168. Hardy, A. V.; DeCapito, T., and Halbert, S. P.: Studies of the Acute Diarrheal Diseases: XIV. Immunization in Shigellosis , Pub. Health Rep. 63:685-688 ( (May 21) ) 1948. 169. Hardy, A. V., and Halbert, S. P.: XX. Further Observations of Chemotherapy in Shigellosis: The Efficacy of Streptomycin and Sulfacarzole , Pub. Health Rep. 63:790-792 ( (June 11) ) 1948. 170. Buchbinder, L., and Steffen, G. I.: Studies in Enterococcal Food Poisoning , Pub. Health Rep. 63:109-118 ( (Jan. 23) ) 1948. 171. Osler, A. G.; Buchbinder, L., and Steffen, G. I.: Experimental Enterococcal Food Poisoning in Man , Proc. Soc. Exper. Biol. & Med. 67:456-459 ( (April) ) 1948. 172. Darnall, C. R.: Paracolon Bacilli as Related to Chronic Dysentery Syndromes , Gastroenterology 10:366-376 ( (March) ) 1948. 173. Rogge, K.: Value of Bone Marrow Puncture as Diagnostic Aid in Children with Typhoid , Arch. f. Kinderh. 134:1-5 ( (June) ) 1947. 174. Ling, C. C.; Liu, J., and Chen, T. Y.: A Comparative Study of Bile, Marrow, Blood, Stool, Urine Cultures and Widal Reaction in Typhoid and Paratyphoid Fevers , Chinese M. J. 66:66-78 ( (Feb.) ) 1948. 175. Dolman, C. E.: Oral Immunization , Am. J. M. Sc. 215:327-351 ( (March) ) 1948. 176. Cholera in Syria and Lebanon, Foreign News , J.A.M.A. 136:195 ( (Jan. 17) ). 177. Report on Cholera in Egypt, General News , J.A.M.A. (Jan. 17) 136:196, 1948. 178. Abdou, S.: Susceptibility to Cholera , Lancet 1:903-904 ( (June 12) ) 1948. 179. Bhatnagar, S. S.; de Sa, J.; Fernandes, F., and Divekar, P. V.: Chemotherapy of Cholera with a New Sulphonamide Compound ("6257"): Laboratory Investigation and Field Trials , Brit. M. J. 1:719-723 ( (April 17) ) 1948. 180. Burrows, W.; Elliott, M. E., and Havens, I.: Studies on Immunity to Asiatic Cholera: IV. Excretion of Coproantibody in Experimental Enteric Cholera in the Guinea Pig , J. Infect. Dis. 81:260-281 ( (Nov.-Dec.) ) 1947. 181. Wei, S. H., and Hao, S. H.: Immunological Studies of Cholera Filtrates , Federation Proc. 7:310 ( (March) ) 1948. 182. Hoyne, A. L., and Brown, R. H.: Seven Hundred and Twenty-Seven Cases: An Analysis , Ann. Int. Med. 28:248-259 ( (Feb.) ) 1948 183. Intrathecal Therapy Not Required for H. Influenzae Meningitis: A Report of Twenty-Eight Cases , J.A.M.A. 136:597-601 ( (Feb. 28) ) 1948. 184. Stigler, S. L., and McLester, J. S.: Gonococcic Meningitis Fifteen Years After Urethritis , J.A.M.A. 136:919-920 ( (April 3) ) 1948.Crossref 185. Lincoln, E. M.; Kirmse, T. W., and DeVito, E.: Tuberculous Meningitis in Children: A Preliminary Report of Its Treatment with Streptomycin and Promizole , J.A.M.A. 136:593-597 ( (Feb. 28) ) 1948.Crossref 186. Goerner, J. R.; Massell, B. F., and Jones, T. D.: Use of Penicillin in Treatment of Carriers of Beta-Hemolytic Streptococci Among Patients with Rheumatic Fever , New England J. Med. 237:576-579 ( (Oct. 16) ) 1947.Crossref 187. Milzer, A.; Kohn, K. H., and MacLean, H.: Oral Prophylaxis of Rheumatic Fever with Penicillin: Resistant Hemolytic Streptococci , J.A.M.A. 136:536-538 ( (Feb. 21) ) 1948.Crossref 188. Weinstein, L., and Tsao, C. C. L.: In Vitro Development of Temporary Penicillin-Resistance in Streptococcus Pyogenes , Proc. Soc. Exper. Biol. & Med. 66:598-602 ( (Dec.) ) 1948. 189. Hartman, T. L., and Weinstein, L.: Drug Sensitivity of Hemolytic Streptococci Isolated from Cases of Scarlet Fever Treated with Penicillin , Proc. Soc. Exper. Biol. & Med. 69:314-316 ( (Nov.) ) 1948. 190. Rothbard, S., and Watson, R. F.: Variation Occurring in Group A Streptococci During Human Infection , J. Exper. Med. 87:521-533 ( (June) ) 1948. 191. Maliner, M. M., and Amsterdam, S. D.: Oral Penicillin in the Prophylaxis of Recurrent Rheumatic Fever , J. Pediat. 31:658-661 ( (Dec.) ) 1947. 192. Gordon, M.: Is Rheumatism a Virus Disease? Lancet 1:697-701 ( (May 8) ) 193. 740-744 (May 15) 1948. 194. McKeown, E. T.: Experimental Serum Carditis and Its Relationship to Rheumatic Fever , J. Path. & Bact. 59:547-555 ( (Oct.) ) 1947. 195. Moore, F. G., and others: Production of Acute Rheumatic-Like Heart Lesions in Mice , Proc. Soc. Exper. Biol. & Med. 65:102-107 ( (May) ) 1947. 196. Hench, P. S., and others: Rheumatism and Arthritis: Review of American and English Literature of Recent Years, (Ninth Rheumatism Review) , Ann. Int. Med. 28:66-168 ( (Jan.) ) 197. 309-451 (Feb.) 1948. 198. Rose, H. M.; Ragon, C.; Pearce, E., and Lipman, M. O.: Differential Agglutination of Normal and Sensitized Sheep Erythrocytes by Sera of Patients with Rheumatoid Arthritis , Proc. Soc. Exper. Biol. & Med. 68:1-6 ( (May) ) 1948. 199. Boucek, R. J., and Lowman, E. W.: Vascular Approach to the Treatment of Rheumatoid Arthritis , Am. J. M. Sc. 215:198-208 ( (Feb.) ) 1948. 200. Groover, M. E., and others: Sensitivity of Skin to Histoplasmin in Differential Diagnosis of Pulmonary Disease , Arch. Int. Med. 80:496-573 ( (Oct.) ) 1947. 201. Kurz, E. R. H., and Loud, N. W.: Coccidioidomycosis in New England , New England J. Med. 237:610-616 ( (Oct. 23) ) 1947. 202. Smith, H.: Coccidioidomycosis in Animals with Report of a New Case in a Dog , Am. J. Path. 24:223-230 ( (Jan.) ) 1948. 203. Stuart, B. M.; Gardner, J. W.; LeMone, D. V., and Van Ravenswaay, A. C.: Pulmonary Histoplasmosis , J. Missouri M. A. 45:417-421 ( (June) ) 1948. 204. Emmons, C. W.; Bell, J. A., and Olson, B. J.: Naturally Occurring Histoplasmosis in Mus Musculus and Rattus Norvegicus , Pub. Health Rep. 62: 1642-1646 ( (Nov. 14) ) 1947. 205. Furcolow, M. I.; Mantz, H. L., and Lewis, I.: The Roentgenographic Appearance of Persistent Pulmonary Infiltrates Associated with Sensitivity to Histoplasmin , Pub. Health Rep. 62:1711-1718 ( (Dec. 5) ) 1947. 206. Furcolow, M. L.; Bunnell, I. L., and Tenenberg, D. J.: A Complement Fixation Test for Histoplasmosis , Pub. Health Rep. 63:169-173 ( (Feb. 6) ) 1948.Crossref 207. Reimann, H. A., and Price, A. H.: Histoplasmosis in Pennsylvania , Pennsylvania M. J. , to be published. 208. Bunnell, I. L.: A Report on Ten Proved Cases of Histoplasmosis , Pub. Health Rep. 63:299-316 ( (March 5) ) 1948.Crossref 209. Holt, J. F.: Roentgenographic Pulmonary Manifestations of Fatal Histoplasmosis , Am. J. Roentgenol. 58:717-723 ( (Dec.) ) 1947. 210. Rawson, A.; Collins, L. H., and Grant, J. L.: Histoplasmosis and Torulosis as Causes of Adrenal Insufficiency , Am. J. M. Sc. 215:363-371 ( (April) ) 1948.Crossref 211. Howell, A., Jr.: Studies of Fungus Antigens: III. Sensitization of Normal Animals with Skin Test Antigens , Pub. Health Rep. 63:595-601 ( (May 7) ) 1948Crossref 212. Isolation of Pathogenic Fungi from Experimentally Inoculated Guinea Pigs , Howell Pub. Health Rep. (May 7) 63:602-616, 1948.Crossref 213. Howell, A.: The Efficiency of Methods for the Isolation of Histoplasmin Capsulatum , Pub. Health Rep. 63:173-178 ( (Feb. 6) ) 1948.Crossref 214. Lee, R. K. C.: Epidemic Tinea Capitis: A Public Health Problem , Pub. Health Rep. 63:261-268 ( (Feb. 27) ) 1948.Crossref 215. Shortt, H. E.; Garnham, J. C. C.; Covell, G., and Shute, P. G.: The Pre-Erythrocytic Stage of Human Malaria, Plasmodium Vivax , Brit. M. J. 1:547 ( (March 20) ) 1948.Crossref 216. Hawking, F.; Perry, W. L. M., and Thurston, J. P.: Tissue Forms of a Malaria Parasite, Plasmodium Cynomolgi , Lancet 1:783-789 ( (May 22) ) 1948.Crossref 217. Control of Trichinosis, report of the Committee on Public Health Relations, the New York Academy of Medicine , Pub. Health Rep. 63:478-488 ( (April 9) ) 1948. 218. Stryker, W. A.: Intestinal Phase of Human Trichinosis , Am. J. Path. 23:819-828 ( (Sept.) ) 1947. 219. Oliver-Gonzalez, J., and Hewitt, R.: Treatment of Experimental Intestinal Trichinosis with 1-Diethylcarbamyl 4-Methylpiperazine Hydrochloride (Hetrazan) , Proc. Soc. Exper. Biol. & Med. 66:254-255 ( (Oct.) ) 1947. 220. Molner, J. G.; Meyer, K. F., and Raskin, H. A.: Leptospiral Infections: A Survey , J.A.M.A. 136:814-819 ( (March 20) ) 1948. 221. Bernkopf, H.: Experimental Leptospirosis Infection in Chickens , Proc. Soc. Exper. Biol. & Med. 67:148-149 ( (Feb.) ) 1948. 222. Buzzard, E. M., and Wylie, J. A. H.: Meningitis Leptospirosa , Lancet 2:417-419 ( (Sept. 20) ) 1947. 223. Dolgopol, V. B.: Histologic Changes in Rickettsial-Pox , Am. J. Path. 24:119-126 ( (Jan.) ) 1948. 224. Fox, J. P., and Olitsky, P. K.: The Long Persistence of Rickettsiae Orientalis in the Blood and Tissues of Infected Animals , abstracted, Federation Proc. 7:305 ( (March) ) 1948. 225. Smadel, J. E.; León, A. P.; Ley, H. L., Jr., and Varelo, G.: Chloromycetin in the Treatment of Patients with Typhus Fever , Proc. Soc. Exper. Biol. & Med. 68:12-19 ( (May) ) 1948. 226. Strauss, E., and Sulkin, S. E.: Studies on Q Fever: Complement-Fixing Antibodies in Meat Packers at Fort Worth, Texas , Proc. Soc. Exper. Biol. & Med. 67:139-141 ( (Feb.) ) 1948. 227. Sulkin, S. E., and Strauss, E.: Studies on Q Fever: Persistence of Complement-Fixing Antibodies After Naturally Acquired Infection , Proc. Soc. Exper. Biol. & Med. 67:142-144 ( (Feb.) ) 1948. 228. Huebner, R. J.; Hottle, G. A., and Robinson, E. B.: Action of Streptomycin in Experimental Infections with Q Fever , Pub. Health Rep. 63:357-362 ( (March 19) ) 1948. 229. Gsell, O.: Q-Fever (Queenslandfieber) in der Schweiz , Schweiz. med. Wchnschr. 78:1-5 ( (Jan.) ) 1948. 230. Huebner, R. J.; Jellison, W. L.; Beck, M. D.; Parker, R. R., and Shepard C. C.: Q Fever Studies in Southern California , Pub. Health Rep. 63:214-222 ( (Feb. 13) ) 1948. 231. Q Fever, editorial , Ann. Int. Med. 29:154-162 ( (July) ) 1948. 232. Reimann, H. A.: Periodic Disease: A Probable Syndrome Including Periodic Fever, Benign Paroxysmal Peritonitis, Cyclic Neutropenia and Intermittent Arthralgia , J.A.M.A. 136:239-244 ( (Jan. 24) ) 1948. 233. Periodic Diseases, editorial , Lancet 1:565-566 ( (April 10) ) 1948. 234. Putnam, P.; Boyd, M. F., and Mead, P. A.: Periodic or Cyclically Recurring Phenomena of Vivax Malaria Infections , Am. J. Hyg. 46:212 ( (Sept. 24) ) 1947. 235. Gross, S. J.: Male Hormones for the Prevention of Relapses in Malaria , Indian M. Gaz. 82:65-66 ( (Feb.) ) 1947. 236. Evans, A. S.: Liver Involvement in Infectious Mononucleosis , J. Clin. Investigation 27:106-110 ( (Jan.) ) 1948. 237. Evans, A. S.: Experimental Attempts to Transmit Infectious Mononucelosis to Man , Yale J. Biol. & Med. 20:19-26 ( (Oct.) ) 1947. 238. Favour, C. B., and Sosman, M. C.: Erythema Nodosum , Arch. Int. Med. 80:435-453 ( (Oct.) ) 1947. 239. Bains, G. H.: Relation of Abacterial Pyuria to Reiter's Syndrome , Brit. M. J. 2:605-608 ( (Oct. 18) ) 1947. 240. Dunham, J.; Rock, J., and Belt, E.: Isolation of a Filtrable Agent Pathogenic for Mice from a Case of Reiter's Disease , J. Urol. 58:212-215 ( (Sept.) ) 1947. 241. Finn, J. J.: Pleurodynia: Preliminary Note on an Epidemic in Boston , New England J. Med. 237:621-623 ( (Oct. 23) ) 1947. 242. Knisely, M. H.: Sludged Blood, Science 106:431-440 ( (Nov. 7) ) 1947. 243. Clark, E. R.: Comment on Knisely , Philadelphia Med. 43:963-965 ( (Feb. 21) ) 1948. 244. Sludged Blood, editorial , J.A.M.A. 136:556-557 ( (Feb. 21) ) 1948. 245. Reimann, H. A.: The Significance of Fever and Blood Protein Changes in Regard to Defense Against Infection , Ann. Int. Med. 6:326-374 ( (Sept.) ) 1932. 246. Milzer, A., and Nathan, S.: Enhancement of Heterophile and Bacterial Agglutination Titers by Means of Serum Diluent , Proc. Soc. Exper. Biol. & Med. 66:619-621 ( (Dec.) ) 1947. 247. Harris, T. N.; Rhoads, J., and Stokes, J.: A Study of the Role of the Thymus and Spleen in the Formation of Antibodies in the Rabbit , J. Immunol. 58:37-42 ( (Jan.) ) 1948. 248. Fagraeus, A.: The Plasma Cellular Reaction and Its Relation to the Formation of Antibodies in Vitro , J. Immunol. 58:1-13 ( (Jan.) ) 1948. 249. Reimann, H. A.; Medes, G., and Fisher, L.: The Origin of Blood Proteins , Folia haemat. 52:187-202, 1934. 250. Palm, J. M.: Hazards of Butchering , J. Indiana M. A. 40:1154-1156 ( (Nov.) ) 1947. 251. Morton, H. E.; North, L. L., and Engley, F. B.: The Bacteriostatic and Bactericidal Actions of Some Mercurial Compounds on Hemolytic Streptococci , J.A.M.A. 136:36-41 ( (Jan. 3) ) 1948.Crossref 252. Brewer, J. H.: Reduction of Infectivity of Certain Pathogenic Bacteria by "Mercurochrome," J.A.M.A. 137:858-861 ( (July 3) ) 1948.Crossref 253. Powell, H. M.: Antibacterial Action of "Merthiolate" Against Hemolytic Streptococci , J.A.M.A. 137:862-864 ( (July 3) ) 1948.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

INFECTIOUS DISEASES: Fourteenth Annual Review of Significant Publications

Archives of Internal Medicine , Volume 82 (5) – Nov 1, 1948

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American Medical Association
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Copyright © 1948 American Medical Association. All Rights Reserved.
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0730-188X
DOI
10.1001/archinte.1948.00220280051005
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Abstract

Abstract THE GREAT DECLINE in the incidence of infectious diseases and in the death rate among patients with such diseases in the past fifty years is an obvious fact. In a calculation of the mortality rate among policy holders of a large life insurance company,1 new low rates in 1947 are reported for whooping cough, diphtheria, influenza, pneumonia, tuberculosis, syphilis and appendicitis. For pneumonia alone the death rate has declined 70 per cent since 1937, when chemotherapy, soon followed by antibiotic therapy, began to be used generally. There is nothing at present which threatens to stem the downward trend to what eventually will be an irreducible minimum. According to Gordon,2 who discusses the influence of disease in war, the ratio of death from disease to deaths in battle gradually and irregularly declined from 7:1 in the Mexican War of 1846 to 0.4:1 in World War I to 0.01:1 in the last war. References 1. Mortality Decline to New Low in 1947 , Statist. Bull. Metrop. Life Insur. Co. 29:1-4 ( (Jan.) ) 1948. 2. Gordon, J. E.: The Strategic and Tactical Influence of Disease in World War II , Am. J. M. Sc. 215:311-326 ( (March) ) 1948.Crossref 3. Ingraham, H. S.: Recent Advances in Communicable Disease Control , New York State J. Med. 48:1135-1141 ( (May 15) ) 1948. 4. Exotic Disease, editorial , J.A.M.A. 136:111-112 ( (Jan. 10) ) 1948. 5. Eagle, H.: Speculation as to the Therapeutic Significance of the Penicillin Blood Level , Ann. Int. Med. 28:260-278 ( (Feb.) ) 1948.Crossref 6. Schachter, R. J.: Fate and Distribution of Penicillin in the Body: I. Circulation of Penicillin in the Lymph , Proc. Soc. Exper. Biol. & Med. 68:29-34 ( (May) ) 1948. 7. Price, A. H.: Aqueous Penicillin Therapy for Pneumococcic Pneumonia: Injection at Twelve Hour Intervals , J.A.M.A. 138:292-293 ( (Sept. 25) ) 1948. 8. White, H. J.; Baker, M. J., and Jackson, E. R.: Therapeutic Effectiveness of Single and Divided Doses of Penicillin in a Streptococcal Infection in Mice , Proc. Soc. Exper. Biol. & Med. 67:199-203 ( (Feb.) ) 1948. 9. Sloan, J. Q.; Bain, G. P., and Brucer, M.: Depth of Penetration of Nebulized Substances in the Respiratory Tree , Proc. Soc. Exper. Biol. & Med. 66:264-267 ( (Oct.) ) 1947. 10. Laurant, A. M.; McIlroy, A. P., and Hadley, F. P.: Penicillin and Streptomycin in the Lungs and Blood Serum of Rats Following Inhalational and Intramuscular Administration , Proc. Soc. Exper. Biol. & Med. 68:213-216 ( (May) ) 1948. 11. Procaine-Penicillin G (Duracillin): A New Salt of Penicillin Which Prolongs the Action of Penicillin , Proc. Staff Meet., Mayo Clin. 22:567-570 ( (Dec. 10) ) 1947. 12. Sullivan, N. P.; Symmes, A. T.; Miller, H. C., and Rhodehamel, H. W., Jr.: A New Penicillin for Prolonged Blood Levels , Science 107:169-170 ( (Feb. 13) ) 1948. 13. Hobby, G. L.; Brown, E., and Patelski, R. A.: Biological Activity of Crystalline Procaine Penicillin in Vitro and in Vivo , Proc. Soc. Exper. Biol. & Med. 67:6-14 ( (Jan.) ) 1948. 14. Hagedorn, A. B., and Scheifley, C. H.: Subacute Bacterial Endocarditis: A Case Report , Proc. Staff Meet., Mayo Clin. 23:14-16 ( (Jan. 7) ) 1948. 15. Barber, M.: Staphylococcal Infection Due to Penicillin-Resistant Strains , Brit. M. J. 2:863-865 ( (Nov. 29) ) 1947. 16. Vander Veer, J. B., and Richardson, F. M.: Penicillin Plus Caronamide in the Treatment of Subacute Bacterial Endocarditis , Tr. & Stud., Coll. Physicians, Philadelphia 15:109-112 ( (Dec.) ) 1947. 17. Miller, C. P.; Hawk, W. D.; and Boore, A. K.: Protection Against Bacterial Endotoxins by Penicillin and Its Impurities , Science 107:118-119 ( (Jan. 30) ) 1948. 18. Hunnicutt, T.; Graf, W. J.; Hamburger, M.; Ferris, E. B., and Scheinker, I. M.: Fatal Toxic Encephalopathy Apparently Caused by Streptomycin , J.A.M.A. 137:599-602 ( (June 12) ) 1948. 19. Rosen, F. 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Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1948

References