Abstract THE LOCAL use of streptokinase-streptodornase (Varidase) offers the surgeon an efficient biologic agent for the treatment of a wide variety of infections. Pus, which contains fibrin and deoxyribonucleoprotein, must be removed to promote healing. Streptokinase is a catalytic agent which activates plasminogen in the euglobulin fraction of the blood. This causes a liquefaction of fibrin and inhibits the conversion of fibrinogen to fibrin. Streptodornase is a group of enzymes which requires catalytic activation by magnesium or manganese ion and which digests deoxyribonucleoprotein. Sherry, Johnson, and Tillett8 showed that streptodornase, acting on purified deoxyribonucleic acid and deoxyribonucleic acid in purulent exudates, produced a great fall in viscosity. Varidase also contains an hyaluronidase,* aproteinase,1 a ribonuclease,4 and several nucleotidases and nucleosidases.† The function of these enzymes in the spread of the compounds in the pus and in the digestion of the various substrates is not well known at the References 1. References 5 and 6. 2. References 2 and 7. 3. The Varidase was supplied by the Lederle Laboratories Division, American Cynamid Company. 4. Elliott, S. D.: Proteolytic Enzyme Produced by Group 14 Streptococci with Special Reference to Its Effect on Type-Specific M Antigen , J. Exper. Med. 81:573-592 ( (June) ) 1945.Crossref 5. Goeller, J., and Sherry, S.: Ultraviolet Photography of Paper Chromatograms in the Study of Nucleic Acids , Proc. Soc. Exper. Biol. & Med. 74:381-382 ( (June) ) 1950. 6. Johnson, A. J.: Cytological Studies in Association with Local Injections of Streptokinase-Streptodornase in Patients , J. Clin. Invest. 29:1376-1386 ( (Oct.) ) 1950. 7. McCarty, M.: Occurrence of Nucleases in Culture Filtrates of Group A Hemolytic Streptococci , J. Exper. Med. 88:181-188 ( (Aug.) ) 1948. 8. Meyer, K.: Chaffee, E.; Hobby, G. L., and Dawson, M. H.: Hydrolysis of Hyaluronic Acid by Bacterial Enzymes , J. Exper. Med. 71:137-146 ( (Feb.) ) 1940. 9. Meyer, K.; Chaffee, E.; Hobby, G. L., and Dawson, M. H.: Hyaluronidases of Bacterial and Animal Origin , J. Exper. Med. 73:309-326 ( (March) ) 1941. 10. Sherry S., and Goeller, J.: Extent of the Enzymatic Degradation of Desoxyribonucleic Acid (DNA) in Purulent Exudates by Streptodornase , J. Clin. Invest. 29:1588-1594 ( (Dec.) ) 1950. 11. Sherry, S.; Johnson, A., and Tillett, W. S.: Action of Streptococcal Desoxyribose Nuclease (Streptodornase) in Vitro and on Purulent Pleural Exudations of Patients , J. Clin. Invest. 28:1094-1104 ( (Sept.) ) 1949.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1954
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