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Infantile Pyknocytosis: A Common Erythrocyte Abnormality of the First Trimester

Infantile Pyknocytosis: A Common Erythrocyte Abnormality of the First Trimester Abstract In the course of an intensive study of full-term newborn infants manifesting hyperbilirubinemia in the absence of hemolytic disease, we became aware of the occurrence of markedly distorted and contracted erythrocytes in the blood of some of these patients. These cells conform to the type previously described under a variety of names, such as "burr cells,"1 "irregularly distorted and contracted erythrocytes,"2 and others. In order to evaluate the significance of these cells it became necessary to determine whether and in what percentage they might normally be found in this age group. We therefore studied unselected full-term and premature infants as well as adults. A significant age-determined relationship was found in that burr cells were encountered in slightly greater numbers in healthy full-term infants than in adults, and in significantly greater numbers in prematures than in full-term infants. Where the number of burr cells was within the physiologic range References 1. Schwartz, S. O., and Motto, S. A.: The Diagnostic Significance of "Burr" Red Blood Cells , Am. J. M. Sc. 218:563, 1949.Crossref 2. Dacie, J. V.: The Haemolytic Anæmias: Congenital and Acquired , London, J. & A. Churchill, Ltd., 1954. 3. Powell, W. N.: A Method for the Quantitative Determination of Serum Bilirubin with the Photoelectric Colorimeter , Am. J. Clin. Path., Tech. Sect. 8:55, 1944. 4. Grunert, R. R., and Phillips, P. H.: A Modification of the Nitroprusside Method of Analysis for Glutathione , Arch. Biochem. 30:217, 1951. 5. Beutler, R.: The Glutathione Instability of Drug Sensitive Red Cells , J. Lab. & Clin. Med. 49: 84, 1957. 6. Zinkham, W.; Lenhard, R. E., Jr., and Childs, B.: A Deficiency of Glucose-6-Phosphate Dehy drogenase Activity in Erythrocytes from Patients with Favism , Bull. Johns Hopkins Hosp. 169:102, 1958. 7. Zuelzer, W. W.; Neel, J. V., and Robinson, A. R.: Abnormal Hemoglobins , in Progress in Hematology , Vol. 1, edited by L. M. Tocantins, New York, Grune & Stratton, Inc., 1956, pp. 91-137. 8. Singer, K.; Chapman, A. Z., and Singer, L.: Studies on Abnormal Hemoglobins: I. Their Demonstration in Sickle Cell Anemia and Other Hematologic Disorders by Means of Alkali Denaturation , Blood 6:413, 1951. 9. Cabaud, P.; Leeper, R., and Wroblewski, F.: Colorimetric Measurement of Serum Glutamic Oxaloacetic Transaminase, Lab News , Scientific Products Division, American Hospital Supply Corporation, Evanston, Ill., 1956. 10. Aherne, W. A.: The "Burr" Red Cell and Azotemia , J. Clin. Path. 10:252, 1957. 11. Gasser, C.; Gautier, E.; Steck, A.; Siebenmann, R. E., and Oechslin, R.: Hämolytischurämische Syndrome: Bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien , Schweiz. med. Wchnschr. 85:905, 1955. 12. Allison, A. C.: Acute Haemolytic Anaemia with Distortion and Fragmentation of Erythrocytes in Children , Brit. J. Haemat. 3:1, 1957. 13. Shumway, C. N., Jr., and Miller, G.: An Unusual Syndrome of Hemolytic Anemia, Thrombo cytopenic Purpura and Renal Disease , Blood 12: 1045, 1957. 14. Gasser, C.: Die hämolytische Frühgeburtenanämie mit spontaner Innenkörperbildung: Ein neues Syndrom, beobachter an 14 Fällen , Helv. paediat. acta 8:491, 1953. 15. Zuelzer, W. W., and Apt, L.: Acute Hemolytic Anemia Due to Naphthalene Poisoning: A Clinical and Experimental Study , J. A. M. A. 141:185, 1949. 16. Sansone, G.; Piga, A. M., and Segui, G.: Il Favismo, Torino, Edizioni Minerva medica S. A., 1958. 17. Bassen, F. A., and Kornzweig, A. L.: Malformation of the Erythrocytes in a Case of Atypical Retinitis Pigmentosa , Blood 5:381, 1950. 18. Singer, K.; Fisher, B., and Perlstein, M. A.: Acanthrocytosis: A Genetic Erythrocytic Malformation , Blood 7:577, 1952. 19. Kove, S.; Goldstein, S., and Wroblewski. F.: Activity of Glutamic-Oxaloacetic Transaminase in the Serum in the Neonatal Period , Pediatrics 20:584, 1957. 20. Brown, A. K.: Specific Defects in Enzyme Systems in the Newborn (Discussion), in Disturbances of Cellular Metabolism in the Immature Infant, Proceedings of the Ross Conference, Chicago, 1959, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Infantile Pyknocytosis: A Common Erythrocyte Abnormality of the First Trimester

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1959.02070020229009
Publisher site
See Article on Publisher Site

Abstract

Abstract In the course of an intensive study of full-term newborn infants manifesting hyperbilirubinemia in the absence of hemolytic disease, we became aware of the occurrence of markedly distorted and contracted erythrocytes in the blood of some of these patients. These cells conform to the type previously described under a variety of names, such as "burr cells,"1 "irregularly distorted and contracted erythrocytes,"2 and others. In order to evaluate the significance of these cells it became necessary to determine whether and in what percentage they might normally be found in this age group. We therefore studied unselected full-term and premature infants as well as adults. A significant age-determined relationship was found in that burr cells were encountered in slightly greater numbers in healthy full-term infants than in adults, and in significantly greater numbers in prematures than in full-term infants. Where the number of burr cells was within the physiologic range References 1. Schwartz, S. O., and Motto, S. A.: The Diagnostic Significance of "Burr" Red Blood Cells , Am. J. M. Sc. 218:563, 1949.Crossref 2. Dacie, J. V.: The Haemolytic Anæmias: Congenital and Acquired , London, J. & A. Churchill, Ltd., 1954. 3. Powell, W. N.: A Method for the Quantitative Determination of Serum Bilirubin with the Photoelectric Colorimeter , Am. J. Clin. Path., Tech. Sect. 8:55, 1944. 4. Grunert, R. R., and Phillips, P. H.: A Modification of the Nitroprusside Method of Analysis for Glutathione , Arch. Biochem. 30:217, 1951. 5. Beutler, R.: The Glutathione Instability of Drug Sensitive Red Cells , J. Lab. & Clin. Med. 49: 84, 1957. 6. Zinkham, W.; Lenhard, R. E., Jr., and Childs, B.: A Deficiency of Glucose-6-Phosphate Dehy drogenase Activity in Erythrocytes from Patients with Favism , Bull. Johns Hopkins Hosp. 169:102, 1958. 7. Zuelzer, W. W.; Neel, J. V., and Robinson, A. R.: Abnormal Hemoglobins , in Progress in Hematology , Vol. 1, edited by L. M. Tocantins, New York, Grune & Stratton, Inc., 1956, pp. 91-137. 8. Singer, K.; Chapman, A. Z., and Singer, L.: Studies on Abnormal Hemoglobins: I. Their Demonstration in Sickle Cell Anemia and Other Hematologic Disorders by Means of Alkali Denaturation , Blood 6:413, 1951. 9. Cabaud, P.; Leeper, R., and Wroblewski, F.: Colorimetric Measurement of Serum Glutamic Oxaloacetic Transaminase, Lab News , Scientific Products Division, American Hospital Supply Corporation, Evanston, Ill., 1956. 10. Aherne, W. A.: The "Burr" Red Cell and Azotemia , J. Clin. Path. 10:252, 1957. 11. Gasser, C.; Gautier, E.; Steck, A.; Siebenmann, R. E., and Oechslin, R.: Hämolytischurämische Syndrome: Bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien , Schweiz. med. Wchnschr. 85:905, 1955. 12. Allison, A. C.: Acute Haemolytic Anaemia with Distortion and Fragmentation of Erythrocytes in Children , Brit. J. Haemat. 3:1, 1957. 13. Shumway, C. N., Jr., and Miller, G.: An Unusual Syndrome of Hemolytic Anemia, Thrombo cytopenic Purpura and Renal Disease , Blood 12: 1045, 1957. 14. Gasser, C.: Die hämolytische Frühgeburtenanämie mit spontaner Innenkörperbildung: Ein neues Syndrom, beobachter an 14 Fällen , Helv. paediat. acta 8:491, 1953. 15. Zuelzer, W. W., and Apt, L.: Acute Hemolytic Anemia Due to Naphthalene Poisoning: A Clinical and Experimental Study , J. A. M. A. 141:185, 1949. 16. Sansone, G.; Piga, A. M., and Segui, G.: Il Favismo, Torino, Edizioni Minerva medica S. A., 1958. 17. Bassen, F. A., and Kornzweig, A. L.: Malformation of the Erythrocytes in a Case of Atypical Retinitis Pigmentosa , Blood 5:381, 1950. 18. Singer, K.; Fisher, B., and Perlstein, M. A.: Acanthrocytosis: A Genetic Erythrocytic Malformation , Blood 7:577, 1952. 19. Kove, S.; Goldstein, S., and Wroblewski. F.: Activity of Glutamic-Oxaloacetic Transaminase in the Serum in the Neonatal Period , Pediatrics 20:584, 1957. 20. Brown, A. K.: Specific Defects in Enzyme Systems in the Newborn (Discussion), in Disturbances of Cellular Metabolism in the Immature Infant, Proceedings of the Ross Conference, Chicago, 1959, to be published.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1959

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