Abstract • A 3½-year-old girl had a three-year history of chronic annular erythema that more closely mimicked erythema gyratum repens of adults than other annular erythemas of infancy. Histopathologic study revealed bowenoid characteristics in the epidermis. No fungi were ever demonstrated in this patient's skin lesions, but they consistently responded to treatment with ketoconazole and flared immediately after cessation of treatment with that drug. (Arch Dermatol 1984;120:1601-1603) References 1. Peterson AO Jr, Jarratt M: Annular erythema of infancy . Arch Dermatol 1981;117:145-148.Crossref 2. Pont A, Williams PL, Loose DS, et al: Ketoconazole blocks adrenal steroid synthesis . Ann Intern Med 1982;97:370-372.Crossref 3. Lever WF, Schaumburg-Lever G: Histopathology of the Skin , ed 5. Philadelphia, JB Lippincott Co, 1975, pp 473-475. 4. Eady AJ: Tubular aggregates: Viral or not? Trans St John's Hosp Dermatol Soc 1975;61:102-104. 5. Borgers M, Van den Bossche H: The mode of action of antifungal drugs , in Levine HB (ed): Ketoconazole in the Management of Fungal Disease . Sydney, Australia, Adis Press, 1982, pp 25-47. 6. Williams ML, Elias PM: Stratum corneum lipids in disorders of cornification: Increased cholesterol sulfate content of stratum corneum in recessive X-linked ichthyosis . J Clin Invest 1981; 68:1404-1410.Crossref
Archives of Dermatology – American Medical Association
Published: Dec 1, 1984
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