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Induction of Subcapsular Cataracts in Cynomolgus Monkeys by Echothiophate

Induction of Subcapsular Cataracts in Cynomolgus Monkeys by Echothiophate Abstract • Sixteen eyes of 13 cynomolgus monkeys were treated topically twice daily with echothiophate iodide. The dosages were increased gradually over several weeks to plateau levels ranging from 125 to 500 μg daily. The opposite eyes of the ten unilaterally treated monkeys received a control solution (DILUENT) identical save for the absence of echothiophate. All 16 echothiophate-treated eyes developed posterior subcapsular cataracts and 15 developed anterior subcapsular cataracts. The lenses in all ten DILUENT-treated eyes remained clear. The cataracts in the echothiophate-treated eyes strongly resembled those attributed to cholinesterase inhibitors in humans. They Were first noted from 2½ to 14 weeks after beginning echothiophate treatment. Prior total iridectomy caused a more rapid progression and/or greater severity of lens changes. Higher echothiophate dosages caused the cataracts to appear more rapidly. (Arch Ophthalmol 95:499-504, 1977) References 1. Axelsson U, Holmberg A: The frequency of cataract after miotic therapy . Acta Ophthalmol 44:421-429, 1966.Crossref 2. Shaffer RN, Hetherington J Jr: Anticholinesterase drugs and cataracts . Am J Ophthalmol 62:613-618, 1966. 3. de Roetth A Jr: Lens opacities in glaucoma patients on phospholine iodide therapy . Am J Ophthalmol 62:619-628, 1966. 4. Tarkkanen A, Karjalainen K: Cataract formation during miotic treatment for chronic open-angle glaucoma . Acta Ophthalmol 44:932-939, 1966.Crossref 5. Axelsson U: Glaucoma, miotic therapy, and cataract: I. The frequency of anterior subcapsular vacuoles in glaucoma eyes treated with echothiophate (phospholine iodide), pilocarpine, or pilocarpine-eserine, and in non-glaucomatous untreated eyes with common senile cataract . Acta Ophthalmol 46:83-98, 1968.Crossref 6. Morton WR, Drance SM, Fairclough M: Effect of echothiophate iodide on the lens . Am J Ophthalmol 68:1003-1010, 1970. 7. Kaufman PL, Axelsson U: Induction of subcapsular cataracts in aniridic vervet monkeys by echothiophate . Invest Ophthalmol 14:863-866, 1975. 8. Kaufman PL, Hahnenberger R: CI:744 anesthesia for ophthalmological examination and surgery in monkeys . Invest Ophthalmol 14:788-791, 1975. 9. Kaufman PL, Lutjen-Drecoll E: Total iridectomy in the primate in vivo: Surgical technique and postoperative anatomy . Invest Ophthalmol 14:766-771, 1975. 10. Kaufman PL, Bárány EH: Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment . Invest Ophthalmol 14:302-306, 1975. 11. Kaufman PL, Bárány EH: Subsensitivity to pilocarpine of the aqueous outflow system in monkey eyes following topical anticholinesterase treatment. Am J Ophthalmol, to be published. 12. Berliner ML: The normal lens; biomicroscopic appearance in Biomicroscopy of the Eye . New York Paul B Hoeber Inc, 1949, chap 23, Vol 2, pp 972, 983, 987, 1008. 13. Hogan MJ, Alvarado JA, Weddell JE: Lens , in Histology of the Human Eye . Philadelphia, WB Saunders Co, 1971, chap 12, pp 642-650. 14. Axelsson U: Glaucoma, miotic therapy and cataract: V. Studies on the lens in glaucoma eyes after discontinuance of echothiophate (Phospholine Iodide) therapy . Acta Ophthalmol 47:1049-1056, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Induction of Subcapsular Cataracts in Cynomolgus Monkeys by Echothiophate

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450030141021
Publisher site
See Article on Publisher Site

Abstract

Abstract • Sixteen eyes of 13 cynomolgus monkeys were treated topically twice daily with echothiophate iodide. The dosages were increased gradually over several weeks to plateau levels ranging from 125 to 500 μg daily. The opposite eyes of the ten unilaterally treated monkeys received a control solution (DILUENT) identical save for the absence of echothiophate. All 16 echothiophate-treated eyes developed posterior subcapsular cataracts and 15 developed anterior subcapsular cataracts. The lenses in all ten DILUENT-treated eyes remained clear. The cataracts in the echothiophate-treated eyes strongly resembled those attributed to cholinesterase inhibitors in humans. They Were first noted from 2½ to 14 weeks after beginning echothiophate treatment. Prior total iridectomy caused a more rapid progression and/or greater severity of lens changes. Higher echothiophate dosages caused the cataracts to appear more rapidly. (Arch Ophthalmol 95:499-504, 1977) References 1. Axelsson U, Holmberg A: The frequency of cataract after miotic therapy . Acta Ophthalmol 44:421-429, 1966.Crossref 2. Shaffer RN, Hetherington J Jr: Anticholinesterase drugs and cataracts . Am J Ophthalmol 62:613-618, 1966. 3. de Roetth A Jr: Lens opacities in glaucoma patients on phospholine iodide therapy . Am J Ophthalmol 62:619-628, 1966. 4. Tarkkanen A, Karjalainen K: Cataract formation during miotic treatment for chronic open-angle glaucoma . Acta Ophthalmol 44:932-939, 1966.Crossref 5. Axelsson U: Glaucoma, miotic therapy, and cataract: I. The frequency of anterior subcapsular vacuoles in glaucoma eyes treated with echothiophate (phospholine iodide), pilocarpine, or pilocarpine-eserine, and in non-glaucomatous untreated eyes with common senile cataract . Acta Ophthalmol 46:83-98, 1968.Crossref 6. Morton WR, Drance SM, Fairclough M: Effect of echothiophate iodide on the lens . Am J Ophthalmol 68:1003-1010, 1970. 7. Kaufman PL, Axelsson U: Induction of subcapsular cataracts in aniridic vervet monkeys by echothiophate . Invest Ophthalmol 14:863-866, 1975. 8. Kaufman PL, Hahnenberger R: CI:744 anesthesia for ophthalmological examination and surgery in monkeys . Invest Ophthalmol 14:788-791, 1975. 9. Kaufman PL, Lutjen-Drecoll E: Total iridectomy in the primate in vivo: Surgical technique and postoperative anatomy . Invest Ophthalmol 14:766-771, 1975. 10. Kaufman PL, Bárány EH: Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment . Invest Ophthalmol 14:302-306, 1975. 11. Kaufman PL, Bárány EH: Subsensitivity to pilocarpine of the aqueous outflow system in monkey eyes following topical anticholinesterase treatment. Am J Ophthalmol, to be published. 12. Berliner ML: The normal lens; biomicroscopic appearance in Biomicroscopy of the Eye . New York Paul B Hoeber Inc, 1949, chap 23, Vol 2, pp 972, 983, 987, 1008. 13. Hogan MJ, Alvarado JA, Weddell JE: Lens , in Histology of the Human Eye . Philadelphia, WB Saunders Co, 1971, chap 12, pp 642-650. 14. Axelsson U: Glaucoma, miotic therapy and cataract: V. Studies on the lens in glaucoma eyes after discontinuance of echothiophate (Phospholine Iodide) therapy . Acta Ophthalmol 47:1049-1056, 1969.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1977

References