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Indapamide in the Diabetic Hypertensive

Indapamide in the Diabetic Hypertensive Abstract To the Editor. —We read with interest the article by Oseï et al1 in the October 1986 issue of the Archives. The authors performed an open study on 13 hypertensive diabetic patients to assess the effects of a 24-week administration of indapamide on blood pressure, glucose, and lipid metabolism. Their results led them to conclude that indapamide may give rise to unfavorable glucose and lipid tolerance in such patients. However, a review of the article raises several questions concerning its methodology.First, of concern is the population included in the study. The small number of patients studied, together with the widely varying characteristics of their diabetes, make the group quite heterogeneous as regards the possible effects of any drugs. For example, the duration of diabetes ranged from 0 to 19 years, fasting serum glucose from 4.5 to 15.6 mmol/L,1 and HbA1 from 5% to 15.7%. In addition, References 1. Oseï K, Holland G, Falko J: Indapamide: Effects on apoprotein, lipoprotein, and gluco-regulation in ambulatory diabetic patients. Arch Intern Med 1986;146:973-1977. 2. Baba S: Study on the safety of long-term administration of indapamide in patients with essential hypertension—especially on the effect on glucose tolerance. Geriatr Med 1982;20:1207-1216. 3. Harrower ADB, McFarlane G, Donnelly T, et al: Effect of indapamide on blood pressure and glucose tolerance in non—insulin-dependent diabetes. Hypertension 1985;( (suppl 2) ):161-163. 4. Raggi U, Palumbo P, Moro B, et al: Inda pamide in the treatment of hypertension in non— insulin-dependent diabetes. Hypertension 1985; ( (suppl 2) ):157-160. 5. Meyer-Sabellek W, Gotzen R, Heitz J, et al: Serum lipoproteins levels during long term treatment of hypertension with indapamide. Hypertension 1985;( (suppl 2) ):170-174. 6. Ames RP: The effects of antihypertension drugs on serum lipids and lipoproteins: I. Diuretics. Drugs 1986;32:260-278.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Indapamide in the Diabetic Hypertensive

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1988.00380090129031
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We read with interest the article by Oseï et al1 in the October 1986 issue of the Archives. The authors performed an open study on 13 hypertensive diabetic patients to assess the effects of a 24-week administration of indapamide on blood pressure, glucose, and lipid metabolism. Their results led them to conclude that indapamide may give rise to unfavorable glucose and lipid tolerance in such patients. However, a review of the article raises several questions concerning its methodology.First, of concern is the population included in the study. The small number of patients studied, together with the widely varying characteristics of their diabetes, make the group quite heterogeneous as regards the possible effects of any drugs. For example, the duration of diabetes ranged from 0 to 19 years, fasting serum glucose from 4.5 to 15.6 mmol/L,1 and HbA1 from 5% to 15.7%. In addition, References 1. Oseï K, Holland G, Falko J: Indapamide: Effects on apoprotein, lipoprotein, and gluco-regulation in ambulatory diabetic patients. Arch Intern Med 1986;146:973-1977. 2. Baba S: Study on the safety of long-term administration of indapamide in patients with essential hypertension—especially on the effect on glucose tolerance. Geriatr Med 1982;20:1207-1216. 3. Harrower ADB, McFarlane G, Donnelly T, et al: Effect of indapamide on blood pressure and glucose tolerance in non—insulin-dependent diabetes. Hypertension 1985;( (suppl 2) ):161-163. 4. Raggi U, Palumbo P, Moro B, et al: Inda pamide in the treatment of hypertension in non— insulin-dependent diabetes. Hypertension 1985; ( (suppl 2) ):157-160. 5. Meyer-Sabellek W, Gotzen R, Heitz J, et al: Serum lipoproteins levels during long term treatment of hypertension with indapamide. Hypertension 1985;( (suppl 2) ):170-174. 6. Ames RP: The effects of antihypertension drugs on serum lipids and lipoproteins: I. Diuretics. Drugs 1986;32:260-278.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1988

References