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Incidence, Recurrence, and Outcomes of Herpes Simplex Virus Eye Disease in Olmsted County, Minnesota, 1976-2007

Incidence, Recurrence, and Outcomes of Herpes Simplex Virus Eye Disease in Olmsted County,... EPIDEMIOLOGY SECTION EDITOR: LESLIE HYMAN, PhD Incidence, Recurrence, and Outcomes of Herpes Simplex Virus Eye Disease in Olmsted County, Minnesota, 1976-2007 The Effect of Oral Antiviral Prophylaxis Ryan C. Young, BA; David O. Hodge, MS; Thomas J. Liesegang, MD; Keith H. Baratz, MD Objectives: To provide an estimate of the incidence of times more likely (95% CI, 5.0-17.9) to have a recur- herpes simplex virus (HSV) eye disease in a community- rence of epithelial keratitis, 8.4 times more likely (95% based cohort, and to investigate the effect of prophylactic CI, 5.2-13.7) to have a recurrence of stromal keratitis, oral antiviral therapy on HSV recurrences and outcomes. and 34.5 times more likely (95% CI, 10.8-111.1) to have a recurrence of blepharitis or conjunctivitis if not being Methods: All Olmsted County, Minnesota, residents di- treated prophylactically at the time of the recurrence. agnosed with ocular HSV from 1976 through 2007 were Twenty patients experienced adverse outcomes, and 17 retrospectively reviewed. The frequency of recurrences (85%) were not being treated with oral antiviral medi- and adverse outcomes, such as vision loss or need for sur- cations immediately preceding the adverse event. gery, were compared between untreated patients and those treated prophylactically with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Incidence, Recurrence, and Outcomes of Herpes Simplex Virus Eye Disease in Olmsted County, Minnesota, 1976-2007

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References (26)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archophthalmol.2010.187
pmid
20837803
Publisher site
See Article on Publisher Site

Abstract

EPIDEMIOLOGY SECTION EDITOR: LESLIE HYMAN, PhD Incidence, Recurrence, and Outcomes of Herpes Simplex Virus Eye Disease in Olmsted County, Minnesota, 1976-2007 The Effect of Oral Antiviral Prophylaxis Ryan C. Young, BA; David O. Hodge, MS; Thomas J. Liesegang, MD; Keith H. Baratz, MD Objectives: To provide an estimate of the incidence of times more likely (95% CI, 5.0-17.9) to have a recur- herpes simplex virus (HSV) eye disease in a community- rence of epithelial keratitis, 8.4 times more likely (95% based cohort, and to investigate the effect of prophylactic CI, 5.2-13.7) to have a recurrence of stromal keratitis, oral antiviral therapy on HSV recurrences and outcomes. and 34.5 times more likely (95% CI, 10.8-111.1) to have a recurrence of blepharitis or conjunctivitis if not being Methods: All Olmsted County, Minnesota, residents di- treated prophylactically at the time of the recurrence. agnosed with ocular HSV from 1976 through 2007 were Twenty patients experienced adverse outcomes, and 17 retrospectively reviewed. The frequency of recurrences (85%) were not being treated with oral antiviral medi- and adverse outcomes, such as vision loss or need for sur- cations immediately preceding the adverse event. gery, were compared between untreated patients and those treated prophylactically with

Journal

JAMA Ophthalmology – American Medical Association

Published: Sep 1, 2010

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