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Incidence of Meconium Abnormalities in Newborn Infants With Cystic Fibrosis

Incidence of Meconium Abnormalities in Newborn Infants With Cystic Fibrosis Abstract • Review of the newborn nursery notes of 87 infants who had cystic fibrosis without meconium ileus (MI) indicated that 12 of them had clinical features consistent with the meconium plug syndrome (MPS). This high incidence of meconium abnormalities suggests that MI and the MPS probably represent different gradations of the same underlying pathologic abnormality. The findings further suggest that a quantitative pilocarpine iontophoresis sweat test be performed in every newborn infant with any type of meconium abnormality, including the spontaneous passage of meconium plugs. (Am J Dis Child 134:72-73, 1980) References 1. Survival Studies of Patients With Cystic Fibrosis . Atlanta, Cystic Fibrosis Foundation, 1977. 2. Grossman H, Berdon WE, Baker DH: Gastro-intestinal findings in cystic fibrosis . Am J Roentgenol Radiat Ther Nucl Med 97:227-238, 1966.Crossref 3. Rosenstein BJ: Cystic fibrosis presenting with the meconium plug syndrome . Am J Dis Child 132:167-169, 1978. 4. Mikity VG, Hodgman JE, Paciulli J: Meconium blockage syndrome . Radiology 88:740-744, 1967.Crossref 5. Swischuk LE: Meconium plug syndrome: A cause of neonatal intestinal obstruction . Am J Roentgenol Radiat Ther Nucl Med 103:339-346, 1968.Crossref 6. Sokal MM, Koenigsberger MR, Rose JS, et al: Neonatal hypermagnesemia and the meconium plug syndrome . N Engl J Med 286:823-825, 1972.Crossref 7. Taybi H, Patterson J: Plain film diagnosis of meconium plug syndrome: Presacral "mass." Radiology 104:113-114, 1972.Crossref 8. Gillis DA, Grantmyre EB: The meconium plug syndrome and Hirschsprung's disease . Can Med Assoc J 92:225-227, 1965. 9. Di Sant'Agnese PA, Lepore MJ: Involvement of abdominal organs in cystic fibrosis of the pancreas . Gastroenterology 40:64-74, 1961. 10. Kopel FB: Gastrointestinal manifestations of cystic fibrosis . Gastroenterology 62:483-491, 1972. 11. Townes PL, Kopelman AE: Meconium plug syndrome, cystic fibrosis, and exocrine pancreatic deficiency . Am J Dis Child 132:1043-1044, 1978. 12. Auburn RP, Feldman SA, Gadacz TR, et al: Meconium ileus secondary to partial aplasia of the pancreas: Report of a case . Surgery 65:689-693, 1969. 13. Oppenheimer EH, Esterly JR: Cystic fibrosis of the pancreas: Morphologic findings in infants with and without diagnostic pancreatic lesions . Arch Pathol 96:149-154, 1973. 14. Stern RC, Doershuk CF, Boat TF, et al: Course of cystic fibrosis in black patients . J Pediatr 89:412-417, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Incidence of Meconium Abnormalities in Newborn Infants With Cystic Fibrosis

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130130054016
Publisher site
See Article on Publisher Site

Abstract

Abstract • Review of the newborn nursery notes of 87 infants who had cystic fibrosis without meconium ileus (MI) indicated that 12 of them had clinical features consistent with the meconium plug syndrome (MPS). This high incidence of meconium abnormalities suggests that MI and the MPS probably represent different gradations of the same underlying pathologic abnormality. The findings further suggest that a quantitative pilocarpine iontophoresis sweat test be performed in every newborn infant with any type of meconium abnormality, including the spontaneous passage of meconium plugs. (Am J Dis Child 134:72-73, 1980) References 1. Survival Studies of Patients With Cystic Fibrosis . Atlanta, Cystic Fibrosis Foundation, 1977. 2. Grossman H, Berdon WE, Baker DH: Gastro-intestinal findings in cystic fibrosis . Am J Roentgenol Radiat Ther Nucl Med 97:227-238, 1966.Crossref 3. Rosenstein BJ: Cystic fibrosis presenting with the meconium plug syndrome . Am J Dis Child 132:167-169, 1978. 4. Mikity VG, Hodgman JE, Paciulli J: Meconium blockage syndrome . Radiology 88:740-744, 1967.Crossref 5. Swischuk LE: Meconium plug syndrome: A cause of neonatal intestinal obstruction . Am J Roentgenol Radiat Ther Nucl Med 103:339-346, 1968.Crossref 6. Sokal MM, Koenigsberger MR, Rose JS, et al: Neonatal hypermagnesemia and the meconium plug syndrome . N Engl J Med 286:823-825, 1972.Crossref 7. Taybi H, Patterson J: Plain film diagnosis of meconium plug syndrome: Presacral "mass." Radiology 104:113-114, 1972.Crossref 8. Gillis DA, Grantmyre EB: The meconium plug syndrome and Hirschsprung's disease . Can Med Assoc J 92:225-227, 1965. 9. Di Sant'Agnese PA, Lepore MJ: Involvement of abdominal organs in cystic fibrosis of the pancreas . Gastroenterology 40:64-74, 1961. 10. Kopel FB: Gastrointestinal manifestations of cystic fibrosis . Gastroenterology 62:483-491, 1972. 11. Townes PL, Kopelman AE: Meconium plug syndrome, cystic fibrosis, and exocrine pancreatic deficiency . Am J Dis Child 132:1043-1044, 1978. 12. Auburn RP, Feldman SA, Gadacz TR, et al: Meconium ileus secondary to partial aplasia of the pancreas: Report of a case . Surgery 65:689-693, 1969. 13. Oppenheimer EH, Esterly JR: Cystic fibrosis of the pancreas: Morphologic findings in infants with and without diagnostic pancreatic lesions . Arch Pathol 96:149-154, 1973. 14. Stern RC, Doershuk CF, Boat TF, et al: Course of cystic fibrosis in black patients . J Pediatr 89:412-417, 1976.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1980

References