Abstract • Hypercalcemia often complicates the course of patients with malignant neoplasms. Since this metabolic derangement is potentially lethal, knowledge of the expected relative incidence of hypercalcemia in various malignant neoplasms is of importance. The incidence of hypercalcemia and malignant neoplasm at the Clinical Center, National Institutes of Health, Bethesda, Md, was reviewed. Of 17,706 admissions (multiple admissions counted once), the overall incidence of hypercalcemia for all disorders was 5.0%; of these, 38.0% (338 patients) had associated neoplasms (99.4% malignant). Primary hyperparathyroidism represented 19.6% of those admitted with hypercalcemia, and nonneoplastic disorders represented 10.7%. Of the 338 patients with hypercalcemia associated with neoplasia, 44.1% had hematologic and 41.4% had solid neoplasms. The relative incidences of hypercalcemia and neoplasia are reported for each of the solid and hematologic neoplasias evaluated. (Arch Surg 115:704-707, 1980) References 1. Andersson A, Bergdahl L: Differentiation of acute hyperparathyroidism from severe hypercalcemia of malignancy . Am J Surg 133:333-337, 1977.Crossref 2. Jessiman AG, Emerson K, Shah RC, et al: Hypercalcemia in carcinoma of the breast . Ann Surg 157:377-393, 1963.Crossref 3. Muggia FM, Heinemann HO: Hypercalcemia associated with neoplastic disease . Ann Int Med 73:281-290, 1970.Crossref 4. Myers WPL: Hypercalcemia in neoplastic disease . Arch Surg 80:140-150, 1960.Crossref 5. Laszlo D, Schulman CA, Bellin J, et al: Mineral and protein metabolism in osteolytic metastases . JAMA 148:1027-1032, 1952.Crossref 6. Plimpton CH, Gellhorn A: Hypercalcemia in malignant disease without evidence of bone destruction . Am J Med 21:750-759, 1956.Crossref 7. Berson SA, Yalow RS: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma . Science 154:907-909, 1966.Crossref 8. Riggs BL, Arnand CD, Reynolds JC, et al: Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer . J Clin Invest 50:2079-2083, 1971.Crossref 9. Sherwood LM, O'Riordan JLH, Aurbach GD, et al: Production of parathyroid hormone by nonparathyroid tumors . J Clin Endocr 27:140-146, 1967.Crossref 10. Tasjian AH Jr, Levine L, Munson PL: Immunochemical identification of parathyroid hormone in nonparathyroid neoplasms associated with hypercalcemia . J Exp Med 119:467-484, 1964.Crossref 11. Demers LM, Allegra JC, Harvey HA, et al: Plasma prostaglandins in hypercalcemic patients with neoplastic disease . Cancer 39:1559-1562, 1977.Crossref 12. Seyberth HW, Segre GV, Morgan JL, et al: Prostaglandins as mediators of hypercalcemia associated with certain types of cancer . N Engl J Med 293:1278-1283, 1975.Crossref 13. Tashjian AH Jr, Voelkel EF, Levine L, et al: Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E2 . J Exp Med 136:1329-1343, 1972.Crossref 14. Mundy GR, Luben RA, Raisz LG, et al: Bone-resorbing activity in supernatants from lymphoid cell lines . N Engl J Med 290:867-871, 1974.Crossref 15. Mundy GR, Raisz LG, Cooper RA, et al: Evidence for the secretion of an osteoclast stimulating factor in myeloma . N Engl J Med 291:1042-1045, 1974.Crossref 16. Gordan GS, Cantino TJ, Erhardt L, et al: Osteolytic sterol in human breast cancer . Science 151:1226-1228, 1966.Crossref 17. Powell D, Singer FR, Murray TM, et al: Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases . N Engl J Med 289:176-181, 1973.Crossref 18. Singer FR, Powell D, Minkin C, et al: Hypercalcemia in reticulum cell sarcoma without hyperparathyroidism or skeletal metastases . Ann Int Med 78:365-369, 1973.Crossref 19. Myers WPL: Hypercalcemia associated with malignant disease , in: Endocrine and Nonendocrine Humoral Producing Tumors: Sixteenth Annual Clinical Conference on Cancer , M. D. Anderson Hospital and Tumor Institute. Chicago, Year Book Medical Publishers Inc, 1973, pp 147-171. 20. Chopra D, Clerkin EP: Hypercalcemia and malignant disease . Med Clin North Am 59:441-447, 1975. 21. Farr HW, Fahey TJ Jr, Nash AG, et al: Primary hyperparathyroidism and cancer . Am J Surg 126:539-543, 1973.Crossref 22. Davis HL Jr, Wisley AN, Ramirez G, et al: Hypercalcemia complicating breast cancer: Clinical features and management . Oncology 28:126-137, 1973.Crossref 23. Warren MM, Utz DG, Kelalis PP: Concurrence of hypernephroma and hypercalcemia . Ann Surg 174:863-865, 1971.Crossref 24. Bender RA, Hansen H: Hypercalcemia in bronchogenic carcinoma: A prospective study of 200 patients . Ann Intern Med 80:205-208, 1974.Crossref 25. Woodard HQ: Changes in blood chemistry associated with carcinoma metastatic to bone . Cancer 6:1219-1227, 1953.Crossref 26. Newsome HH: Multiple endocrine adenomatosis . Surg Clin North Am 54:387-393, 1974.
Archives of Surgery – American Medical Association
Published: Jun 1, 1980