Abstract HEPATITIS has become an important problem in the practice of medicine during the past two decades. Its incidence is increasing. Originally, attention was focused upon the liver because of damage produced by hepatotoxic agents in therapy, as well as in industry. Of the drugs and chemicals responsible for liver damage, the following may be cited: cinchopen, sulfonamides, bismuth, arsenicals, colloidal gold, quinine, and quinacrine hydrochloride (atabrine® dihydrochloride).1 Among the industrial poisons are carbon tetrachloride, which is outstanding, trinitrotoluene, tetrachloroethylene, and phosphorus. Chloroform and ether are other chemical poisons which may act as toxic irritants on the liver.2 Many infections are capable of producing acute hepatic injury, i. e., virus pneumonia, infectious mononucleosis,3 acute brucellosis, malaria,4 and amebiasis. During World War II a great number of cases of hepatitis appeared in epidemic form, and it was discovered that the etiological factor in many of them wasa virus with a definite incubation References 1. Anderson, C. E.; Cornatzer, W. E., and Andrews, J. C.: The Role of the Liver in Metabolic Destruction of Quinine , J. Pharmacol. & Exper. Therap. 79:62-69 ( (Sept.) ) 1943. 2. Jones, C. M.: Medical Progress: Liver Intoxication , New England J. Med. 230:766-774 ( (June 22) ) 1944. 3. Bennett, H. D.; Frankel, J. J.; Bedinger, B., and Baker, L. A.: Infectious Mononucleosis with Hepatitis , Arch. Int. Med. 86:391-401 ( (Sept.) ) 1950. 4. Capps, R. B.; Sborov, V. M., and Barker, M. H.: The Diagnosis of Infectious Hepatitis , J. A. M. A. 134:595-597 ( (June 14) ) 1947. 5. Bruyn, H. B.: Homologous Serum Hepatitis Following Transfusion in Infant , J. Pediat. 31:60 ( (July) ) 1947 6. abstracted, J. A. M. A. 135:383 ( (Oct. 11) ) 1947. 7. Murphy, H. M.: Transmission of Infectious Hepatitis by Blood Transfusions , Gastroenterology 5:449-456 ( (Dec.) ) 1945. 8. Rosenthal, L. T.: Four Cases of Homologous Serum Hepatitis , Gastroenterology 9:1-17 ( (July) ) 1947. 9. Koszalka, M. F.; Lindert, M. C. F.; Snodgrass, H. M., and Lerner, H. B.: Hepatitis and Its Sequelae , Arch. Int. Med. 84:782-797 ( (Nov.) ) 1949. 10. Havens, W. P., Jr.: The Etiology of Infectious Hepatitis , J. A. M. A. 134:653-655 ( (June 21) ) 1947. 11. Laird, S. M.: Syringe-Transmitted Hepatitis , Glasgow M. J. 28:199-219 ( (Aug.) ) 1947. 12. Sherwood, P. M.: An Outbreak of Syringe-Transmitted Hepatitis with Jaundice in Hospitalized Diabetic Patients , Ann. Int. Med. 33:380-396 ( (Aug.) ) 1950. 13. Rosenthal, N.; Bassen, F. A., and Michael, S. R.: Probable Transmission of Viral Hepatitis by Ultraviolet-Irradiated Plasma , J. A. M. A. 144:224-226 ( (Sept. 16) ) 1950. 14. James, G.; Korns, R. F., and Wright, A. W.: Homologous Serum Jaundice Associated with Use of Irradiated Plasma , J. A. M. A. 144:228-229 ( (Sept. 16) ) 1950. 15. Applebaum, E., and Gelfand, B. B.: Artificial Transmission of Malaria Among Intravenous Diacetylmorphine Addicts , J. A. M. A. 102:1664-1670 ( (May 19) ) 1934. 16. Altschul, A., and Foster, P. D.: Analysis of Admissions for Narcotic Addiction at Harlem Hospital, 1948-1950: A Statistical Study , Harlem Hosp. Bull. , to be published. 17. Steigmann, F.; Hyman, S., and Goldbloom, R.: Infectious Hepatitis (Homologous Serum Type) in Drug Addicts , Gastroenterology 15:642-646 ( (Aug.) ) 1950.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1952