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Inadvertent Rubella Vaccination of Pregnant Women

Inadvertent Rubella Vaccination of Pregnant Women Two hundred fifteen cases of inadvertent rubella vaccination in early pregnancy or shortly before conception have been studied to determine the risk of fetal infection with rubella vaccine-like virus (RVV). Of the 215 women, 184 (86%) did not have prevaccination sero-immunity screening. Only 24 women (11%) were known to be susceptible prior to vaccination. One hundred seven (50%) of the pregnancies ended with induced abortions, 12 (5%) with spontaneous abortions, and 96 (45%) with live births. None of the live-born infants had serologic or clinical evidence of congenital rubella; however, RVV was isolated from abortion specimens in seven cases, three of which had isolates from fetal tissue. The similarities between RVV and wild rubella virus infection of decidual, placental, and fetal tissue strongly suggest that RVV poses a definite hazard to the fetus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Inadvertent Rubella Vaccination of Pregnant Women

JAMA , Volume 225 (12) – Sep 17, 1973

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1973.03220400018004
Publisher site
See Article on Publisher Site

Abstract

Two hundred fifteen cases of inadvertent rubella vaccination in early pregnancy or shortly before conception have been studied to determine the risk of fetal infection with rubella vaccine-like virus (RVV). Of the 215 women, 184 (86%) did not have prevaccination sero-immunity screening. Only 24 women (11%) were known to be susceptible prior to vaccination. One hundred seven (50%) of the pregnancies ended with induced abortions, 12 (5%) with spontaneous abortions, and 96 (45%) with live births. None of the live-born infants had serologic or clinical evidence of congenital rubella; however, RVV was isolated from abortion specimens in seven cases, three of which had isolates from fetal tissue. The similarities between RVV and wild rubella virus infection of decidual, placental, and fetal tissue strongly suggest that RVV poses a definite hazard to the fetus.

Journal

JAMAAmerican Medical Association

Published: Sep 17, 1973

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