Abstract Inactivation of chromium ion in allergic eczematous dermatitis with an antichrome agent was demonstrated by patch test studies in chromate-sensitive patients.1,2 The purpose of this paper is to report on the stability of our antichrome agent in solutions and ointment bases, on the removal of hexavalent chromium from various materials, and on experiments in volunteers using chromate solution and antichrome. The results indicate the usefulness of the antichrome reagent for the prevention of industrial chromium dermatitis. Further studies are now being carried out in various industries under actual working conditions. Studies on the Stability of Solutions of Antichrome Agent The object of this investigation was to study the stability of solutions of our antichrome agent. We have found that solutions of the agent lose their effectiveness upon standing. Therefore, it became necessary to determine how long solutions of the agent remain potent. Reagents and Test Solutions.—1. Antichrome agent References 1. Carbowax base consisted of propylene 10%, Carbowax (4000) 30%, and Carbowax (1500) 60%. 2. Samitz, M. H.; Gross, S., and Katz, S.: Inactivation of Chromium Ion in Allergic Eczematous Dermatitis , J. Invest. Derm. , to be published. 3. Samitz, M. H., and Gross, S.: Effects of Hexavalent and Trivalent Chromium Compounds on the Skin , Arch. Derm. 84:404-409 ( (Sept.) ) 1961.Crossref 4. Samitz, M. H.: Some Dermatologic Aspects of the Chromate Problem , A.M.A. Arch. Industr. Health 11:361-367 ( (May) ) 1955. 5. Samitz, M. H., and Epstein, E.: Chrome Ulcers in Guinea Pigs, to be published. 6. Samitz, M. H.: Dermatitis in the Printing and Lithographing Industries, unpublished data.
Archives of Dermatology – American Medical Association
Published: May 1, 1962