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INACTIVATION OF ANTIBODIES: A Causative Factor of Brain Pathology in Acute Lead Intoxication

INACTIVATION OF ANTIBODIES: A Causative Factor of Brain Pathology in Acute Lead Intoxication Abstract THE CASE of a 23-month-old girl, who died after an acute illness of a week, was studied in this hospital. The interrelationship of somatic disease and the pathological functioning and pathological anatomy of the central nervous system has been a topic of emphasis in the laboratory of neuropathology of this Institute. There is the principle that the kind, predilection, and distribution of lesions of the central nervous system are to be understood through the subtlety of the interrelation of multiple factors. This idea contrasts with the previous belief in the specificity of changes in the central nervous system. The emphasis on the interrelationship of somatic disease and changes in the functioning and anatomy of the central nervous system has given increasing meaningfulness to this principle. The neuropathological findings observed in this case seemed most consistent with a pathogenesis of bacterial toxins derived from a bacterial growth in the circulating blood, References 1. References 3 and 4. 2. References 3 and 4. 3. References 5 and 6. 4. References 9 and 10. 5. Freeman, W.: Neuropathology , Philadelphia, W. B. Saunders Company, 1933, p. 247. 6. Hassin, G. B.: Histopathology of the Peripheral and Central Nervous Systems , Chicago, the Author, 1948, p. 293. 7. Spielmeyer, W.: Histopathologie des Nervensystems , Berlin, Springer-Verlag, 1922. 8. Wertham, F.: The Brain as an Organ , New York, The Macmillan Company, 1943. 9. Blackman, S. S., Jr.: Lesions of Lead Encephalitis in Children , Bull. Johns Hopkins Hosp. 61:1-61, 1937. 10. Akelaitis, A. J.: Lead Encephalopathy in Children and Adults , J. Nerv. & Ment. Dis. 93:313-332, 1941. 11. Kunkel, H. G.: Estimation of Alterations of Serum Gamma Globulin by a Turbidimetric Technique , Proc. Soc. Exper. Biol. & Med. 66:217-224, 1947. 12. Goodman, L., and Gilman, A.: Pharmacological Basis of Therapeutics , New York, The Macmillan Company, 1941. 13. Sementini, A.: Hemolytic Amboceptors and Lead Poisoning , Boll. Soc. ital. biol. sper. 17:679-680, 1942. 14. Gentile, F.: Lead Poisoning and the Production of Agglutinins in Relation to Recent Knowledge of the Structure of Salmonella Type Antigens , Brit. J. Indust. Med. 5:96, 1948. 15. Ford, F. R.: Diseases of the Nervous System in Infancy, Childhood and Adolescence , Springfield, Ill., Charles C Thomas, Publisher, 1944, p. 662. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

INACTIVATION OF ANTIBODIES: A Causative Factor of Brain Pathology in Acute Lead Intoxication

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1954.02330050049008
Publisher site
See Article on Publisher Site

Abstract

Abstract THE CASE of a 23-month-old girl, who died after an acute illness of a week, was studied in this hospital. The interrelationship of somatic disease and the pathological functioning and pathological anatomy of the central nervous system has been a topic of emphasis in the laboratory of neuropathology of this Institute. There is the principle that the kind, predilection, and distribution of lesions of the central nervous system are to be understood through the subtlety of the interrelation of multiple factors. This idea contrasts with the previous belief in the specificity of changes in the central nervous system. The emphasis on the interrelationship of somatic disease and changes in the functioning and anatomy of the central nervous system has given increasing meaningfulness to this principle. The neuropathological findings observed in this case seemed most consistent with a pathogenesis of bacterial toxins derived from a bacterial growth in the circulating blood, References 1. References 3 and 4. 2. References 3 and 4. 3. References 5 and 6. 4. References 9 and 10. 5. Freeman, W.: Neuropathology , Philadelphia, W. B. Saunders Company, 1933, p. 247. 6. Hassin, G. B.: Histopathology of the Peripheral and Central Nervous Systems , Chicago, the Author, 1948, p. 293. 7. Spielmeyer, W.: Histopathologie des Nervensystems , Berlin, Springer-Verlag, 1922. 8. Wertham, F.: The Brain as an Organ , New York, The Macmillan Company, 1943. 9. Blackman, S. S., Jr.: Lesions of Lead Encephalitis in Children , Bull. Johns Hopkins Hosp. 61:1-61, 1937. 10. Akelaitis, A. J.: Lead Encephalopathy in Children and Adults , J. Nerv. & Ment. Dis. 93:313-332, 1941. 11. Kunkel, H. G.: Estimation of Alterations of Serum Gamma Globulin by a Turbidimetric Technique , Proc. Soc. Exper. Biol. & Med. 66:217-224, 1947. 12. Goodman, L., and Gilman, A.: Pharmacological Basis of Therapeutics , New York, The Macmillan Company, 1941. 13. Sementini, A.: Hemolytic Amboceptors and Lead Poisoning , Boll. Soc. ital. biol. sper. 17:679-680, 1942. 14. Gentile, F.: Lead Poisoning and the Production of Agglutinins in Relation to Recent Knowledge of the Structure of Salmonella Type Antigens , Brit. J. Indust. Med. 5:96, 1948. 15. Ford, F. R.: Diseases of the Nervous System in Infancy, Childhood and Adolescence , Springfield, Ill., Charles C Thomas, Publisher, 1944, p. 662.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Nov 1, 1954

References