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In Rebuttal

In Rebuttal Abstract In her discussion of a recent article by us1 on the effect of food dyes on hyperactive children, Dr Wender raises an interesting point about the performance of our subjects during the day following challenges with placebo. She claims that the differences in performance between the dye and placebo conditions can be accounted for by an "unexpected pattern of response" by the hyperactive group of subjects in the placebo condition, and she recommends that our results be seriously questioned until this unexpected response is explained. In fact, for the procedures used in our study and data analysis, the pattern of performance in the hyperactive group after a placebo challenge is virtually identical to the pattern we reported earlier,2 and it is the pattern of the nonhyperactive (or less hyperactive) group that differs from our previous report. Thus, the opposite of Dr Wender's claim may be true for our data. References 1. Swanson JM, Kinsbourne M: Food dyes impair performance of hyperactive children on a laboratory learning test . Science 1980;207:1485-1487.Crossref 2. Kinsbourne M, Swanson JM, Herman D: Laboratory measurement of hyperactive children's response to stimulant medication , in Denhoff E, Stern L (eds): Minimal Brain Dysfunction: A Developmental Approach . New York, Masson Publishing Co, 1979, pp 81-106. 3. Swanson JM, Kinsbourne M, Roberts W, et al: Time-response analysis of the effect of stimulant medication on the learning ability of children referred for hyperactivity . Pediatrics 1978;61:21-29. 4. Conners CK: Food Additives and Hyperactive Children . New York, Plenum Press Inc, to be published. 5. Swanson JM, Kinsbourne M: Artificial color and hyperative behavior , in Knights RM, Bakker DJ (eds): Treatment of Hyperactive and Learning Disabled Children. Baltimore, University Park Press , 1980, pp 131-149. 6. Weiss B, Williams JH, Margen S, et al: Behavioral responses to artificial food colors . Science 1980;207:1487-1488.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130240008003
Publisher site
See Article on Publisher Site

Abstract

Abstract In her discussion of a recent article by us1 on the effect of food dyes on hyperactive children, Dr Wender raises an interesting point about the performance of our subjects during the day following challenges with placebo. She claims that the differences in performance between the dye and placebo conditions can be accounted for by an "unexpected pattern of response" by the hyperactive group of subjects in the placebo condition, and she recommends that our results be seriously questioned until this unexpected response is explained. In fact, for the procedures used in our study and data analysis, the pattern of performance in the hyperactive group after a placebo challenge is virtually identical to the pattern we reported earlier,2 and it is the pattern of the nonhyperactive (or less hyperactive) group that differs from our previous report. Thus, the opposite of Dr Wender's claim may be true for our data. References 1. Swanson JM, Kinsbourne M: Food dyes impair performance of hyperactive children on a laboratory learning test . Science 1980;207:1485-1487.Crossref 2. Kinsbourne M, Swanson JM, Herman D: Laboratory measurement of hyperactive children's response to stimulant medication , in Denhoff E, Stern L (eds): Minimal Brain Dysfunction: A Developmental Approach . New York, Masson Publishing Co, 1979, pp 81-106. 3. Swanson JM, Kinsbourne M, Roberts W, et al: Time-response analysis of the effect of stimulant medication on the learning ability of children referred for hyperactivity . Pediatrics 1978;61:21-29. 4. Conners CK: Food Additives and Hyperactive Children . New York, Plenum Press Inc, to be published. 5. Swanson JM, Kinsbourne M: Artificial color and hyperative behavior , in Knights RM, Bakker DJ (eds): Treatment of Hyperactive and Learning Disabled Children. Baltimore, University Park Press , 1980, pp 131-149. 6. Weiss B, Williams JH, Margen S, et al: Behavioral responses to artificial food colors . Science 1980;207:1487-1488.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Dec 1, 1980

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