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Improving Care for Heart Failure With Reduced Ejection Fraction—A Potential Polypill-Based Strategy

Improving Care for Heart Failure With Reduced Ejection Fraction—A Potential Polypill-Based Strategy This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design and evaluate the pill and implementation strategies for getting it to patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Improving Care for Heart Failure With Reduced Ejection Fraction—A Potential Polypill-Based Strategy

Agarwal, Anubha; Yancy, Clyde W.; Huffman, Mark D.
JAMA , Volume 324 (22) – Dec 8, 2020
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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2020.21395
Publisher site
See Article on Publisher Site

Abstract

This Viewpoint proposes that a polypill combination of a β-blocker, renin angiotensin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose cotransporter 2 inhibitor might be the most efficient way to deliver guideline-directed HFrEF therapy, and proposes a research roadmap to design and evaluate the pill and implementation strategies for getting it to patients.

Journal

JAMA – American Medical Association

Published: Dec 8, 2020

Keywords: polycap,heart failure with reduced ejection fraction,oral contraceptives,mineralocorticoid receptor antagonists

References

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  • Use of concept mapping to characterize relationships among implementation strategies and assess their feasibility and importance
    Waltz, TJ; Powell, BJ; Matthieu, MM
  • Hospital-based quality improvement interventions for patients with heart failure
    Agarwal, A; Bahiru, E; Yoo, SGK
  • Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran)
    Roshandel, G; Khoshnia, M; Poustchi, H