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IMPROVED FERTILITY AND PREVENTION OF ABORTION AFTER NUTRITIONAL-HORMONAL THERAPY

IMPROVED FERTILITY AND PREVENTION OF ABORTION AFTER NUTRITIONAL-HORMONAL THERAPY Abstract The causes of functional infertility are obscure and elusive. Those of abnormal pregnancy and habitual abortion are no less so. Many factors of nutritional and endocrine significance may be involved, but thus far these have been loosely defined and so remain in a rather confused state. We postulate that many cases of functional infertility and abortion may result from errors in sex hormone metabolism associated with variable degrees of nutritional and hepatic insufficiency. This concept is based on abundant evidence from investigators in the field of nutrition1 and from workers investigating the influence of the liver on sex endocrine function.2 Previous observations clearly relate liver damage with gonadal damage.8 These clinical and experimental data tend to support the idea that livergonadal syndromes may be associated with infertility. Hepatic insufficiency is frequently the cause of the following sex organ changes: in men, testicular damage, gynecomastia, impotence, and infertility; References 1. Mason, K. E.: Nutrition and Reproduction , in Survey of Biological Progress , Avery, G. S., editor, New York, Academic Press, Inc., 1949, vol. 1, pp. 89-114. 2. Evans, H. M., and Bishop, K. S.: Relations Between Fertility and Nutrition: Normal Reproductive Performance of Rats , J. Metab. Research 3: 201-231, 1923 3. Production of Sterility with Nutritional Regimes Adequate for Growth and Its Cure with Other Foodstuffs , Bishop J. Metab. Research 3:233-316, 1923. 4. Glass, S. J.: Influence of Liver on Sex Endocrine Function , in Progress in Clinical Endocrinology , Soskin, S., editor, New York, Grune & Stratton, Inc., 1950, chap. 4. 5. Glass, S. J.; Edmondson, H. A., and Soll, S. N.: Sex Hormone Changes Associated with Liver Disease , Endocrinology 27:749-752, 1940.Crossref 6. Feiner, M.; Krichesky, B., and Glass, S. J.: Effect of Induced Liver Cirrhosis on Reproductive System of the Male Rat , Proc. Soc. Exper. Biol. & Med. 66:235-239, 1947. 7. Furlong, E.; Krichesky, B., and Glass, S. J.: Effect of Carbon Tetrachloride—Feeding on Estrogen Excretion in Normal Female Guinea Pig , Endocrinology 45: 1-9, 1949. 8. Biskind, G. R.: Experimental Demonstration of Inactivation of Certain Sex Steroid Androgens and Estrogens in Vivo , in Medico-Surgical Tributes to Harold Brunn , Berkeley, Calif., University of California Press, 1942, pp. 41-58. 9. Harrow, B.: Interrelationships of Enzymes, Vitamins, and Hormones , Scient. Month. 64: 242-246, 1947. 10. Biskind, M. S., and Falk, H. C.: Nutritional Therapy of Infertility in the Male , J. Clin. Endocrinol. 3: 148-153, 1943. 11. Biskind, M. S.: Technic of Nutritional Therapy , Am. J. Digest. Dis. 20: 57-67, 1953. 12. The liver function tests were usually determination of sulfobromophthalein (Bromsulphalein) secretion, cephalin flocculation, thymol turbidity, and glycogen storage (Kinsell). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

IMPROVED FERTILITY AND PREVENTION OF ABORTION AFTER NUTRITIONAL-HORMONAL THERAPY

JAMA , Volume 154 (11) – Mar 13, 1954

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1954.02940450028009
Publisher site
See Article on Publisher Site

Abstract

Abstract The causes of functional infertility are obscure and elusive. Those of abnormal pregnancy and habitual abortion are no less so. Many factors of nutritional and endocrine significance may be involved, but thus far these have been loosely defined and so remain in a rather confused state. We postulate that many cases of functional infertility and abortion may result from errors in sex hormone metabolism associated with variable degrees of nutritional and hepatic insufficiency. This concept is based on abundant evidence from investigators in the field of nutrition1 and from workers investigating the influence of the liver on sex endocrine function.2 Previous observations clearly relate liver damage with gonadal damage.8 These clinical and experimental data tend to support the idea that livergonadal syndromes may be associated with infertility. Hepatic insufficiency is frequently the cause of the following sex organ changes: in men, testicular damage, gynecomastia, impotence, and infertility; References 1. Mason, K. E.: Nutrition and Reproduction , in Survey of Biological Progress , Avery, G. S., editor, New York, Academic Press, Inc., 1949, vol. 1, pp. 89-114. 2. Evans, H. M., and Bishop, K. S.: Relations Between Fertility and Nutrition: Normal Reproductive Performance of Rats , J. Metab. Research 3: 201-231, 1923 3. Production of Sterility with Nutritional Regimes Adequate for Growth and Its Cure with Other Foodstuffs , Bishop J. Metab. Research 3:233-316, 1923. 4. Glass, S. J.: Influence of Liver on Sex Endocrine Function , in Progress in Clinical Endocrinology , Soskin, S., editor, New York, Grune & Stratton, Inc., 1950, chap. 4. 5. Glass, S. J.; Edmondson, H. A., and Soll, S. N.: Sex Hormone Changes Associated with Liver Disease , Endocrinology 27:749-752, 1940.Crossref 6. Feiner, M.; Krichesky, B., and Glass, S. J.: Effect of Induced Liver Cirrhosis on Reproductive System of the Male Rat , Proc. Soc. Exper. Biol. & Med. 66:235-239, 1947. 7. Furlong, E.; Krichesky, B., and Glass, S. J.: Effect of Carbon Tetrachloride—Feeding on Estrogen Excretion in Normal Female Guinea Pig , Endocrinology 45: 1-9, 1949. 8. Biskind, G. R.: Experimental Demonstration of Inactivation of Certain Sex Steroid Androgens and Estrogens in Vivo , in Medico-Surgical Tributes to Harold Brunn , Berkeley, Calif., University of California Press, 1942, pp. 41-58. 9. Harrow, B.: Interrelationships of Enzymes, Vitamins, and Hormones , Scient. Month. 64: 242-246, 1947. 10. Biskind, M. S., and Falk, H. C.: Nutritional Therapy of Infertility in the Male , J. Clin. Endocrinol. 3: 148-153, 1943. 11. Biskind, M. S.: Technic of Nutritional Therapy , Am. J. Digest. Dis. 20: 57-67, 1953. 12. The liver function tests were usually determination of sulfobromophthalein (Bromsulphalein) secretion, cephalin flocculation, thymol turbidity, and glycogen storage (Kinsell).

Journal

JAMAAmerican Medical Association

Published: Mar 13, 1954

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