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Improved Control of Epilepsy by Monitoring Plasma Ethosuximide

Improved Control of Epilepsy by Monitoring Plasma Ethosuximide Abstract Plasma ethosuximide level was monitored in 70 patients with absence (petit mal) seizures. Levels were linearly related to administered dose. Of 37 ambulatory patients with uncontrolled attacks, 38% (14) had levels below the 95% tolerance limit in contrast to 9% (5) of the controlled group. This difference, due to noncompliance with therapy, was eliminated by regular monitoring. Appropriate adjustment of plasma ethosuximide levels resulted in a reduction of seizures in 48% (18) of previously uncontrolled patients. Practical control of epilepsy increased from 64% (45) to 81% (57). Monitoring of plasma ethosuximide increases the effectiveness of therapy by the recognition of noncompliance and the individualization of drug requirements. References 1. Zimmerman FT, Burgemeister BB: A new drug for petit mal epilepsy . Neurology 8:769-775, 1958.Crossref 2. Goldensohn ES, Hardie J, Borea ED: Ethosuximide in the treatment of epilepsy . JAMA 180:840-842, 1962.Crossref 3. Livingston S, Pauli L, Najmabadi A: Ethosuximide in the treatment of epilepsy . JAMA 180:822-825, 1962.Crossref 4. Penry JK, Porter RJ, Dreifuss FE: Ethosuximide: Relation of plasma levels to clinical control , in Woodbury DM, Penry JK, Schmidt RP (eds): Antiepileptic Drugs . New York, Raven Press, 1972, pp 431-441. 5. Kutt H, Haynes J, McDowell F: Some causes of ineffectiveness of diphenylhydantoin . Arch Neurol 14:489-492, 1966.Crossref 6. Glazko AJ, Dill WA: Ethosuximide: Chemistry and methods for determination , in Woodbury DM, Penry JK, Schmidt RB (eds): Antiepileptic Drugs . New York, Raven Press, 1972, pp 413-415. 7. Lennox WG: The petit mal epilepsies: Their treatment with tridione . JAMA 129:1069-1074, 1945.Crossref 8. Gibberd FB: The prognosis of petit mal . Brain 89:531-538, 1966.Crossref 9. Holowach J, Thurston DL, O'Leary JL: Petit mal epilepsy . Pediatrics 30:893-901, 1962. 10. Lees F, Liversedge LA: The prognosis of "petit mal" and minor epilepsy . Lancet 2:797-799, 1962.Crossref 11. Janz D: Die Epilepsien-Spezielle Pathologie und Therapie . Stuttgart, Georg Thieme, 1969, p 94. 12. Marston MV: Compliance with medical regimens: A review of the literature . Nurs Res 19:312-323, 1970.Crossref 13. Buchthal F, Svensmark O, Schiller PJ: Clinical and electroencephalographic correlations with serum levels of diphenylhydantoin . Arch Neurol 2:624-630, 1960.Crossref 14. Lund M, Jørgensen RS, Kühl V: Serum diphenylhydantoin (phenytoin) in ambulant patients with epilepsy . Epilepsia 5:51-58, 1964.Crossref 15. Gibberd FB, et al: Supervision of epileptic patients taking phenytoin . Br Med J 1:147-149, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Improved Control of Epilepsy by Monitoring Plasma Ethosuximide

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Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1973.00490210058007
Publisher site
See Article on Publisher Site

Abstract

Abstract Plasma ethosuximide level was monitored in 70 patients with absence (petit mal) seizures. Levels were linearly related to administered dose. Of 37 ambulatory patients with uncontrolled attacks, 38% (14) had levels below the 95% tolerance limit in contrast to 9% (5) of the controlled group. This difference, due to noncompliance with therapy, was eliminated by regular monitoring. Appropriate adjustment of plasma ethosuximide levels resulted in a reduction of seizures in 48% (18) of previously uncontrolled patients. Practical control of epilepsy increased from 64% (45) to 81% (57). Monitoring of plasma ethosuximide increases the effectiveness of therapy by the recognition of noncompliance and the individualization of drug requirements. References 1. Zimmerman FT, Burgemeister BB: A new drug for petit mal epilepsy . Neurology 8:769-775, 1958.Crossref 2. Goldensohn ES, Hardie J, Borea ED: Ethosuximide in the treatment of epilepsy . JAMA 180:840-842, 1962.Crossref 3. Livingston S, Pauli L, Najmabadi A: Ethosuximide in the treatment of epilepsy . JAMA 180:822-825, 1962.Crossref 4. Penry JK, Porter RJ, Dreifuss FE: Ethosuximide: Relation of plasma levels to clinical control , in Woodbury DM, Penry JK, Schmidt RP (eds): Antiepileptic Drugs . New York, Raven Press, 1972, pp 431-441. 5. Kutt H, Haynes J, McDowell F: Some causes of ineffectiveness of diphenylhydantoin . Arch Neurol 14:489-492, 1966.Crossref 6. Glazko AJ, Dill WA: Ethosuximide: Chemistry and methods for determination , in Woodbury DM, Penry JK, Schmidt RB (eds): Antiepileptic Drugs . New York, Raven Press, 1972, pp 413-415. 7. Lennox WG: The petit mal epilepsies: Their treatment with tridione . JAMA 129:1069-1074, 1945.Crossref 8. Gibberd FB: The prognosis of petit mal . Brain 89:531-538, 1966.Crossref 9. Holowach J, Thurston DL, O'Leary JL: Petit mal epilepsy . Pediatrics 30:893-901, 1962. 10. Lees F, Liversedge LA: The prognosis of "petit mal" and minor epilepsy . Lancet 2:797-799, 1962.Crossref 11. Janz D: Die Epilepsien-Spezielle Pathologie und Therapie . Stuttgart, Georg Thieme, 1969, p 94. 12. Marston MV: Compliance with medical regimens: A review of the literature . Nurs Res 19:312-323, 1970.Crossref 13. Buchthal F, Svensmark O, Schiller PJ: Clinical and electroencephalographic correlations with serum levels of diphenylhydantoin . Arch Neurol 2:624-630, 1960.Crossref 14. Lund M, Jørgensen RS, Kühl V: Serum diphenylhydantoin (phenytoin) in ambulant patients with epilepsy . Epilepsia 5:51-58, 1964.Crossref 15. Gibberd FB, et al: Supervision of epileptic patients taking phenytoin . Br Med J 1:147-149, 1970.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1973

References

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