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Improved Acanthosis Nigricans With Lipodystrophic Diabetes During Dietary Fish Oil Supplementation

Improved Acanthosis Nigricans With Lipodystrophic Diabetes During Dietary Fish Oil Supplementation Abstract • Acanthosis nigricans is well recognized in its clinical association with several types of insulin-resistant syndromes, and skin involvement is usually unresponsive to local treatment or management of diabetes. A young woman with a lipodystrophic form of diabetes, hypertriglyceridemia, and severe generalized acanthosis nigricans was placed on a diet with fat supplementation in the form of omega-3-fatty-acid-rich fish oil. She was observed to have striking improvement in the appearance and extent of acanthosis nigricans while receiving this regimen. This occurred despite continued therapy with niacin (nicotinic acid), an agent associated with acanthosis nigricanslike skin changes. (Arch Dermatol 1988;124:1094-1096) References 1. Kahn CR, Flier JS, Bar RS, et al: The syndromes of insulin resistance and acanthosis nigricans: Insulin receptor disorders in man . N Engl J Med 1976;294:739-745.Crossref 2. Reed WB, Dexter R, Corley C, et al: Congenital lipodystrophic diabetes with acanthosis nigricans: The Seip-Lawrence syndrome . Arch Dermatol 1965;91:326-334.Crossref 3. Brubaker MM, Levan NE, Collipp PJ: Acanthosis nigricans and congenital total lipodystrophy . Arch Dermatol 1965;91:320-325.Crossref 4. Janaki VR, Premalatha S, Raghuverra N, et al: Lawrence-Seip syndrome . Br J Dermatol 1980;103:693-696.Crossref 5. Ober KP: Acanthosis nigricans and insulin resistance associated with hypothyroidism . Arch Dermatol 1985;121:229-231.Crossref 6. Bar RS, Muggeo M, Roth J, et al: Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: Evidence for a postreceptor defect . J Clin Endocrinol Metab 1978;47:620-625.Crossref 7. Vesely DL, Coleman MJ, Kohler PO, et al: Hyperalimentation as cause of markedly worsened metabolic control in a patient with autoantibodies to the insulin receptor . Am J Med 1985;79:504-508.Crossref 8. Stacpoole PW, Alig J, Kilgore LL, et al: Lipodystrophic diabetes mellitus: Investigations of lipoprotein metabolism and the effects of omega-3 fatty acid administration in two patients . Metabolism , in press. 9. Lever WF, Schaumburg-Lever G: Acanthosis nigricans , in Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott, 1983, p 430. 10. Lerner AB: On the cause of acanthosis nigricans . N Engl J Med 1975;281:106-107. 11. Nordlund JJ, Lerner AB: Cause of acanthosis nigricans . N Engl J Med 1975;281:200. 12. Flier JS, Young JB, Landsberg L: Familial insulin resistance with acanthosis nigricans, acral hypertrophy, and muscle cramps . N Engl J Med 1980;303:970-973.Crossref 13. Ellis D, Nanney L, Kafka S, et al: Growth factor (EGF, TGF-A, TGF-B) involvement in cutaneous paraneoplastic syndromes associated with melanoma , abstracted. J Invest Dermatol 1987;88:487. 14. Flier JS: Metabolic importance of acanthosis nigricans . Arch Dermatol 1985;121:193-194.Crossref 15. Verrando P, Ortonne JP: Insulin receptors in cultured human keratinocytes . Br J Dermatol 1984;111( (suppl 27) ):232-234.Crossref 16. Insulin receptors, acanthosis nigricans, and insulin resistance , editorial. Lancet 1986;1:595-596. 17. Ziboh VA, Cohen KA, Ellis CN, et al: Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids: Modulation of clinical course of psoriatic subjects . Arch Dermatol 1986;122:1277-1282.Crossref 18. Kragballe K, Voorhees JJ, Goetzel EJ: Inhibition by leukotriene B5 of leukotriene B4-induced activation of human keratinocytes and neutrophils . J Invest Dermatol 1987;88:555-558.Crossref 19. Cunnane SC, Manku MS, Horrobin DF: Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic acid and gamma-linolenic acids . Br J Nutr 1985;53:449-458.Crossref 20. Lowe NJ, Stoughton RB: Essential fatty acid deficient hairless mouse: A model of chronic epidermal hyperproliferation . Br J Dermatol 1977;96:155-162.Crossref 21. Elias PM, Brown BE: The mammalian cutaneous permeability barrier: Defective barrier function in essential fatty acid deficiency correlates with abnormal intercellular lipid deposition . Lab Invest 1978;39:574-583. 22. Tromovitch TA, Jacobs PH, Kern S: Acanthosis nigricans and nicotinic acid . Arch Dermatol 1964;89:222-223.Crossref 23. Elgart ML: Acanthosis nigricans and nicotinic acid . J Am Acad Dermatol 1981;5:709-710.Crossref 24. Brown MS, Goldstein JL: Drugs used in the treatment of hyperlipoproteinemias , in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics , ed 7. New York, Macmillan Publishing Co Inc, 1985, pp 834-835. 25. Zackheim HS, Vasily DB, Westphal ML, et al: Reactions to niacinamide . J Am Acad Dermatol 1981;4:736-737.Crossref 26. Papa CM: Niacinamide and acanthosis nigricans . Arch Dermatol 1984;120:1281.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Improved Acanthosis Nigricans With Lipodystrophic Diabetes During Dietary Fish Oil Supplementation

Archives of Dermatology , Volume 124 (7) – Jul 1, 1988

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670070082026
Publisher site
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Abstract

Abstract • Acanthosis nigricans is well recognized in its clinical association with several types of insulin-resistant syndromes, and skin involvement is usually unresponsive to local treatment or management of diabetes. A young woman with a lipodystrophic form of diabetes, hypertriglyceridemia, and severe generalized acanthosis nigricans was placed on a diet with fat supplementation in the form of omega-3-fatty-acid-rich fish oil. She was observed to have striking improvement in the appearance and extent of acanthosis nigricans while receiving this regimen. This occurred despite continued therapy with niacin (nicotinic acid), an agent associated with acanthosis nigricanslike skin changes. (Arch Dermatol 1988;124:1094-1096) References 1. Kahn CR, Flier JS, Bar RS, et al: The syndromes of insulin resistance and acanthosis nigricans: Insulin receptor disorders in man . N Engl J Med 1976;294:739-745.Crossref 2. Reed WB, Dexter R, Corley C, et al: Congenital lipodystrophic diabetes with acanthosis nigricans: The Seip-Lawrence syndrome . Arch Dermatol 1965;91:326-334.Crossref 3. Brubaker MM, Levan NE, Collipp PJ: Acanthosis nigricans and congenital total lipodystrophy . Arch Dermatol 1965;91:320-325.Crossref 4. Janaki VR, Premalatha S, Raghuverra N, et al: Lawrence-Seip syndrome . Br J Dermatol 1980;103:693-696.Crossref 5. Ober KP: Acanthosis nigricans and insulin resistance associated with hypothyroidism . Arch Dermatol 1985;121:229-231.Crossref 6. Bar RS, Muggeo M, Roth J, et al: Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: Evidence for a postreceptor defect . J Clin Endocrinol Metab 1978;47:620-625.Crossref 7. Vesely DL, Coleman MJ, Kohler PO, et al: Hyperalimentation as cause of markedly worsened metabolic control in a patient with autoantibodies to the insulin receptor . Am J Med 1985;79:504-508.Crossref 8. Stacpoole PW, Alig J, Kilgore LL, et al: Lipodystrophic diabetes mellitus: Investigations of lipoprotein metabolism and the effects of omega-3 fatty acid administration in two patients . Metabolism , in press. 9. Lever WF, Schaumburg-Lever G: Acanthosis nigricans , in Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott, 1983, p 430. 10. Lerner AB: On the cause of acanthosis nigricans . N Engl J Med 1975;281:106-107. 11. Nordlund JJ, Lerner AB: Cause of acanthosis nigricans . N Engl J Med 1975;281:200. 12. Flier JS, Young JB, Landsberg L: Familial insulin resistance with acanthosis nigricans, acral hypertrophy, and muscle cramps . N Engl J Med 1980;303:970-973.Crossref 13. Ellis D, Nanney L, Kafka S, et al: Growth factor (EGF, TGF-A, TGF-B) involvement in cutaneous paraneoplastic syndromes associated with melanoma , abstracted. J Invest Dermatol 1987;88:487. 14. Flier JS: Metabolic importance of acanthosis nigricans . Arch Dermatol 1985;121:193-194.Crossref 15. Verrando P, Ortonne JP: Insulin receptors in cultured human keratinocytes . Br J Dermatol 1984;111( (suppl 27) ):232-234.Crossref 16. Insulin receptors, acanthosis nigricans, and insulin resistance , editorial. Lancet 1986;1:595-596. 17. Ziboh VA, Cohen KA, Ellis CN, et al: Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids: Modulation of clinical course of psoriatic subjects . Arch Dermatol 1986;122:1277-1282.Crossref 18. Kragballe K, Voorhees JJ, Goetzel EJ: Inhibition by leukotriene B5 of leukotriene B4-induced activation of human keratinocytes and neutrophils . J Invest Dermatol 1987;88:555-558.Crossref 19. Cunnane SC, Manku MS, Horrobin DF: Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic acid and gamma-linolenic acids . Br J Nutr 1985;53:449-458.Crossref 20. Lowe NJ, Stoughton RB: Essential fatty acid deficient hairless mouse: A model of chronic epidermal hyperproliferation . Br J Dermatol 1977;96:155-162.Crossref 21. Elias PM, Brown BE: The mammalian cutaneous permeability barrier: Defective barrier function in essential fatty acid deficiency correlates with abnormal intercellular lipid deposition . Lab Invest 1978;39:574-583. 22. Tromovitch TA, Jacobs PH, Kern S: Acanthosis nigricans and nicotinic acid . Arch Dermatol 1964;89:222-223.Crossref 23. Elgart ML: Acanthosis nigricans and nicotinic acid . J Am Acad Dermatol 1981;5:709-710.Crossref 24. Brown MS, Goldstein JL: Drugs used in the treatment of hyperlipoproteinemias , in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics , ed 7. New York, Macmillan Publishing Co Inc, 1985, pp 834-835. 25. Zackheim HS, Vasily DB, Westphal ML, et al: Reactions to niacinamide . J Am Acad Dermatol 1981;4:736-737.Crossref 26. Papa CM: Niacinamide and acanthosis nigricans . Arch Dermatol 1984;120:1281.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1988

References