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Impaired Recognition of Meaningful Sounds in Alzheimer's Disease

Impaired Recognition of Meaningful Sounds in Alzheimer's Disease Abstract • We studied recognition of meaningful nonverbal sounds using a sound-picture matching test in 18 patients with senile dementia of the Alzheimer type (SDAT) and 19 age-matched controls. A significant impairment of sound recognition was found in the SDAT group, consistent with auditory sound agnosia. Although sound recognition performance correlated significantly with auditory verbal comprehension scores, a sound recognition defect was also identifiable in the subgroup of patients with SDAT who had normal verbal comprehension. Qualitative analysis of sound recognition errors revealed that nonaphasic patients with SDAT made predominantly acoustic errors, whereas semantic errors were found almost exclusively in aphasic patients. These findings suggest that the auditory sound agnosia of patients with SDAT may be subdivided into perceptual-discriminative and semantic-associative types. References 1. Hecaen H, Albert ML. Human Neuropsychology . New York, NY: John Wiley & Sons Inc; 1978:248-276. 2. Bauer RM, Rubens AB. Agnosia . In: Heilman KM, Valenstein E, eds. Clinical Neuropsychology . New York, NY: Oxford University Press Inc; 1985:187-241. 3. Spreen O, Benton AL, Fincham RW. Auditory agnosia without aphasia . Arch Neurol . 1965;13:84-92.Crossref 4. Albert ML, Sparks R, von Stockert T, Sax D. A case study of auditory agnosia: linguistic and nonlinguistic processing . Cortex . 1972;8:427-433.Crossref 5. Vignolo LA. Auditory agnosia: a review and report of recent evidence . In: Benton AL, ed. Contributions to Clinical Neuropsychology . Chicago, Ill: Aldine Publishing Co; 1969:172-208. 6. Vignolo LA. Auditory agnosia . Philos Trans R Soc Lond Biol . 1982;298:49-57.Crossref 7. Spinnler H, Vignolo LA. Impaired recognition of meaningful sounds in aphasia . Cortex . 1966;2:337-348.Crossref 8. Faglioni P, Spinnler H, Vignolo LA. Contrasting behavior of right and left hemisphere damaged patients on a discriminative and a semantic task of auditory recognition . Cortex . 1969;5:366-389.Crossref 9. Varney NR. Sound recognition in relation to aural language comprehension in aphasic patients . J Neurol Neurosurg Psychiatry . 1980;43:71-75.Crossref 10. Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician . J Psychiatr Res . 1975;12:189-198.Crossref 11. McKhann G, Drachman D, Folstein MF, Katzman R, Price F, Stadlan EM. Clinical diagnosis of Alzheimer's disease . Neurology . 1984;34:939-944.Crossref 12. Finitzo-Hieber T, Matkin ND, Cherow-Skalka E, Gerling IJ. Sound Effects Recognition Test (SERT) . St Louis, Mo: Auditec; 1977. 13. Kertesz A. The Western Aphasia Battery . New York, NY: Grune & Stratton; 1982. 14. De Renzi E, Scotti G, Spinnler H. Perceptual and associative disorders of visual recognition: their relationship to the side of the cerebral lesion . Neurology . 1969;19:634-642.Crossref 15. De Renzi E, Spinnler H. Impaired performance on color tasks in patients with hemispheric damage . Cortex . 1967;3:194-216.Crossref 16. Geschwind N. The Development of the Brain and the Evolution of Language . Washington, DC: Georgetown University Press; 1964;17:155-169. Monograph Series on Languages and Linguistics. 17. Geschwind N. Disconnexion syndromes in animals and man . Brain . 1965;88:237-294, 585-644.Crossref 18. Butters N, Brody BA. The role of the left parietal lobe in the mediation of intra- and cross-modal associations . Cortex . 1968;4:328-343.Crossref 19. Butters N, Barton M, Brody BA. Role of the right parietal lobe in the mediation of crossmodal associations and reversible operations in space . Cortex . 1970;6:174-190.Crossref 20. Varney NR, Damasio H. CT scan correlates of sound recognition defect in aphasia . Cortex . 1986;22:483-486.Crossref 21. Brun A, Gustafson L. Distribution of cerebral degeneration in Alzheimer's disease: a clinico-pathological study . Arch Psychiatr Nervenkr . 1976;223:15-33. 22. Brun A, Englund E. Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading . Histopathology . 1981;5:549-564.Crossref 23. Hagberg B, Ingvar DH. Cognitive reduction in presenile dementia related to regional abnormalities of the cerebral blood flow . Br J Psychiatry . 1976;128:209-222.Crossref 24. Ingvar DH, Risberg J, Schwartz MS. Evidence of subnormal function of association cortex in presenile dementia . Neurology . 1975;25:964-974.Crossref 25. Friedland RP, Budinger TF, Ganz E, et al. Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with the [18F] fluorodeoxyglucose . J Comput Assist Tomogr . 1983;7:590-598.Crossref 26. Chase TN, Foster NL, Fedio P, Brooks R, Mansi L, Di Chiro G. Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography . Ann Neurol . 1984;15( (suppl) ):170-174.Crossref 27. Friedland RP, Brun A, Budinger TF. Pathological and positron emission tomographic correlations in Alzheimer's disease . Lancet . 1985;1:228.Crossref 28. Friedland RP, Budinger TF, Koss E, Ober BA. Alzheimer's disease: anterior-posterior and lateral hemispheric alterations in cortical glucose utilization . Neurosci Lett . 1985;53:235-240.Crossref 29. Lewis DA, Campbell MJ, Terry RD, Morrison JH. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices . J Neurosci . 1987;7:1799-1808. 30. Liepmann H. Ein Fall von reiner Sprachtaubheit . In: Psychiatrische Abhandlungen . Breslau, Germany: Schletter; 1898. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Impaired Recognition of Meaningful Sounds in Alzheimer's Disease

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1989.00520480040017
Publisher site
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Abstract

Abstract • We studied recognition of meaningful nonverbal sounds using a sound-picture matching test in 18 patients with senile dementia of the Alzheimer type (SDAT) and 19 age-matched controls. A significant impairment of sound recognition was found in the SDAT group, consistent with auditory sound agnosia. Although sound recognition performance correlated significantly with auditory verbal comprehension scores, a sound recognition defect was also identifiable in the subgroup of patients with SDAT who had normal verbal comprehension. Qualitative analysis of sound recognition errors revealed that nonaphasic patients with SDAT made predominantly acoustic errors, whereas semantic errors were found almost exclusively in aphasic patients. These findings suggest that the auditory sound agnosia of patients with SDAT may be subdivided into perceptual-discriminative and semantic-associative types. References 1. Hecaen H, Albert ML. Human Neuropsychology . New York, NY: John Wiley & Sons Inc; 1978:248-276. 2. Bauer RM, Rubens AB. Agnosia . In: Heilman KM, Valenstein E, eds. Clinical Neuropsychology . New York, NY: Oxford University Press Inc; 1985:187-241. 3. Spreen O, Benton AL, Fincham RW. Auditory agnosia without aphasia . Arch Neurol . 1965;13:84-92.Crossref 4. Albert ML, Sparks R, von Stockert T, Sax D. A case study of auditory agnosia: linguistic and nonlinguistic processing . Cortex . 1972;8:427-433.Crossref 5. Vignolo LA. Auditory agnosia: a review and report of recent evidence . In: Benton AL, ed. Contributions to Clinical Neuropsychology . Chicago, Ill: Aldine Publishing Co; 1969:172-208. 6. Vignolo LA. Auditory agnosia . Philos Trans R Soc Lond Biol . 1982;298:49-57.Crossref 7. Spinnler H, Vignolo LA. Impaired recognition of meaningful sounds in aphasia . Cortex . 1966;2:337-348.Crossref 8. Faglioni P, Spinnler H, Vignolo LA. Contrasting behavior of right and left hemisphere damaged patients on a discriminative and a semantic task of auditory recognition . Cortex . 1969;5:366-389.Crossref 9. Varney NR. Sound recognition in relation to aural language comprehension in aphasic patients . J Neurol Neurosurg Psychiatry . 1980;43:71-75.Crossref 10. Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician . J Psychiatr Res . 1975;12:189-198.Crossref 11. McKhann G, Drachman D, Folstein MF, Katzman R, Price F, Stadlan EM. Clinical diagnosis of Alzheimer's disease . Neurology . 1984;34:939-944.Crossref 12. Finitzo-Hieber T, Matkin ND, Cherow-Skalka E, Gerling IJ. Sound Effects Recognition Test (SERT) . St Louis, Mo: Auditec; 1977. 13. Kertesz A. The Western Aphasia Battery . New York, NY: Grune & Stratton; 1982. 14. De Renzi E, Scotti G, Spinnler H. Perceptual and associative disorders of visual recognition: their relationship to the side of the cerebral lesion . Neurology . 1969;19:634-642.Crossref 15. De Renzi E, Spinnler H. Impaired performance on color tasks in patients with hemispheric damage . Cortex . 1967;3:194-216.Crossref 16. Geschwind N. The Development of the Brain and the Evolution of Language . Washington, DC: Georgetown University Press; 1964;17:155-169. Monograph Series on Languages and Linguistics. 17. Geschwind N. Disconnexion syndromes in animals and man . Brain . 1965;88:237-294, 585-644.Crossref 18. Butters N, Brody BA. The role of the left parietal lobe in the mediation of intra- and cross-modal associations . Cortex . 1968;4:328-343.Crossref 19. Butters N, Barton M, Brody BA. Role of the right parietal lobe in the mediation of crossmodal associations and reversible operations in space . Cortex . 1970;6:174-190.Crossref 20. Varney NR, Damasio H. CT scan correlates of sound recognition defect in aphasia . Cortex . 1986;22:483-486.Crossref 21. Brun A, Gustafson L. Distribution of cerebral degeneration in Alzheimer's disease: a clinico-pathological study . Arch Psychiatr Nervenkr . 1976;223:15-33. 22. Brun A, Englund E. Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading . Histopathology . 1981;5:549-564.Crossref 23. Hagberg B, Ingvar DH. Cognitive reduction in presenile dementia related to regional abnormalities of the cerebral blood flow . Br J Psychiatry . 1976;128:209-222.Crossref 24. Ingvar DH, Risberg J, Schwartz MS. Evidence of subnormal function of association cortex in presenile dementia . Neurology . 1975;25:964-974.Crossref 25. Friedland RP, Budinger TF, Ganz E, et al. Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with the [18F] fluorodeoxyglucose . J Comput Assist Tomogr . 1983;7:590-598.Crossref 26. Chase TN, Foster NL, Fedio P, Brooks R, Mansi L, Di Chiro G. Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography . Ann Neurol . 1984;15( (suppl) ):170-174.Crossref 27. Friedland RP, Brun A, Budinger TF. Pathological and positron emission tomographic correlations in Alzheimer's disease . Lancet . 1985;1:228.Crossref 28. Friedland RP, Budinger TF, Koss E, Ober BA. Alzheimer's disease: anterior-posterior and lateral hemispheric alterations in cortical glucose utilization . Neurosci Lett . 1985;53:235-240.Crossref 29. Lewis DA, Campbell MJ, Terry RD, Morrison JH. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices . J Neurosci . 1987;7:1799-1808. 30. Liepmann H. Ein Fall von reiner Sprachtaubheit . In: Psychiatrische Abhandlungen . Breslau, Germany: Schletter; 1898.

Journal

Archives of NeurologyAmerican Medical Association

Published: Dec 1, 1989

References