Abstract A patient with lichen myxedematosus of 13 years' duration has experienced stabilization or regression of the disease. The long duration of clinical well-being suggests that this patient is not suffering from a variant of multiple myeloma. Serum protein studies reveal an abnormal serum protein in the γ-globulin region. Immunoglobulin IgA levels in serum are abnormally high. Circulating antibody responses after immunization with Vi and brucellin antigens and delayed hypersensitivity responses in this patient are apparently normal. References 1. Prepared from Escherichia coli. 2. McCarthy, J.T, et al: An Abnormal Serum Globulin in Lichen Myxedematosus , Arch Derm 89:446-450, 1964.Crossref 3. James, K., et al: Lichen Myxedematosus: A Rare Dermatologic Disease Associated With a Unique Serum Paraprotein , Clin Res 14:138, 1966. 4. Fahey, J.L.; and McKelvey, E.M.: Quantitative Determination of Serum Immunoglobulins in Antibody-Agar Plates , J Immun 94:84-90, 1965. 5. Landy, M.; et al: Studies on the O Antigen of Salmonella typhosa: II. Immunological Properties of the Purified Antigen , J Immun 74:466-478, 1955. 6. Huddleson, I.F.; and Abell, E.: Rapid Macroscopic Agglutination for the Serum Diagnosis of Bang's Abortion Disease , J Infect Dis 42:242-247, 1928.Crossref 7. Welch, H.; and Stuart, C.A.: A Rapid Slide Test for the Serologic Diagnosis of Typhoid and Paratyphoid Fevers , J Lab Clin Med 21:411-417, 1936.
Archives of Dermatology – American Medical Association
Published: Apr 1, 1967