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Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women

Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women Key PointsQuestionWhat is the immunogenicity of COVID-19 messenger RNA (mRNA) vaccines in pregnant and lactating women? FindingsIn this cohort study involving 103 women who received a COVID-19 mRNA vaccine, 30 of whom were pregnant and 16 of whom were lactating, immunogenicity was demonstrated in all, and vaccine-elicited antibodies were found in infant cord blood and breast milk. Pregnant and nonpregnant vaccinated women developed cross-reactive immune responses against SARS-CoV-2 variants of concern. MeaningIn a small convenience sample, COVID-19 mRNA vaccines were immunogenic in pregnant and lactating women and induced immune responses against SARS-CoV-2 variants. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2021.7563
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the immunogenicity of COVID-19 messenger RNA (mRNA) vaccines in pregnant and lactating women? FindingsIn this cohort study involving 103 women who received a COVID-19 mRNA vaccine, 30 of whom were pregnant and 16 of whom were lactating, immunogenicity was demonstrated in all, and vaccine-elicited antibodies were found in infant cord blood and breast milk. Pregnant and nonpregnant vaccinated women developed cross-reactive immune responses against SARS-CoV-2 variants of concern. MeaningIn a small convenience sample, COVID-19 mRNA vaccines were immunogenic in pregnant and lactating women and induced immune responses against SARS-CoV-2 variants.

Journal

JAMAAmerican Medical Association

Published: Jun 15, 2021

References