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Immunogenetic Factors in Preeclampsia and Eclampsia-Reply

Immunogenetic Factors in Preeclampsia and Eclampsia-Reply Abstract Although we carefully stated in our article that the results of our study did not rule out other potential immunologic mechanisms, maternal-fetal incompatibility with respect to blood group, HLA, or Y-linked transplantation antigens is extremely unlikely as a cause of the preeclampsia-eclampsia syndrome. Drs Toivanen and Hirvonen apparently disagree with this conclusion but give no new data to support their opinion. Because of the infrequency of severe preeclampsia and eclampsia, we consider our series of patients to be a relatively large one. Perhaps it should be pointed out that the initial communication demonstrating the striking association between the HLA-B27 antigen and ankylosing spondylitis reported 40 patients with the disorder.1 More tissue-typing of mothers and infants may be desirable but would not alter the fact that one of the eclamptic women reported was ABO- and Rh-compatible and shared two common HLA antigens with her female fetus. This indicates References 1. Schlosstein L, Terasaki PI, Bluestone R, et al: High association of an HLA antigen, W27, with ankylosing spondylitis . N Engl J Med 288:704, 1973.Crossref 2. Tiilikainen A: Feto-maternal histoincompatibility in toxaemia of pregnancy , in Human Anti-Human Gammaglobulins . Oxford, England, Pergamon Press, 1971, pp 223-227. 3. Juberg RC, Gaar DG, Humphries JR, et al: Sex ratio in the progeny of mothers with toxemia of pregnancy. J Reprod Med 16:299, 1976. 4. Scott JR, Beer AE: Immunologic aspects of preeclampsia . Am J Obstet Gynecol 125:418, 1976. 5. Scott JS, Jenkins DM: Immunogenetic factors in aetiology of pre-eclampsia-eclampsia (gestosis) . J Med Genet 13:200, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Immunogenetic Factors in Preeclampsia and Eclampsia-Reply

JAMA , Volume 236 (19) – Nov 8, 1976

Immunogenetic Factors in Preeclampsia and Eclampsia-Reply

Abstract

Abstract Although we carefully stated in our article that the results of our study did not rule out other potential immunologic mechanisms, maternal-fetal incompatibility with respect to blood group, HLA, or Y-linked transplantation antigens is extremely unlikely as a cause of the preeclampsia-eclampsia syndrome. Drs Toivanen and Hirvonen apparently disagree with this conclusion but give no new data to support their opinion. Because of the infrequency of severe preeclampsia and eclampsia, we...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1976.03270200011006
Publisher site
See Article on Publisher Site

Abstract

Abstract Although we carefully stated in our article that the results of our study did not rule out other potential immunologic mechanisms, maternal-fetal incompatibility with respect to blood group, HLA, or Y-linked transplantation antigens is extremely unlikely as a cause of the preeclampsia-eclampsia syndrome. Drs Toivanen and Hirvonen apparently disagree with this conclusion but give no new data to support their opinion. Because of the infrequency of severe preeclampsia and eclampsia, we consider our series of patients to be a relatively large one. Perhaps it should be pointed out that the initial communication demonstrating the striking association between the HLA-B27 antigen and ankylosing spondylitis reported 40 patients with the disorder.1 More tissue-typing of mothers and infants may be desirable but would not alter the fact that one of the eclamptic women reported was ABO- and Rh-compatible and shared two common HLA antigens with her female fetus. This indicates References 1. Schlosstein L, Terasaki PI, Bluestone R, et al: High association of an HLA antigen, W27, with ankylosing spondylitis . N Engl J Med 288:704, 1973.Crossref 2. Tiilikainen A: Feto-maternal histoincompatibility in toxaemia of pregnancy , in Human Anti-Human Gammaglobulins . Oxford, England, Pergamon Press, 1971, pp 223-227. 3. Juberg RC, Gaar DG, Humphries JR, et al: Sex ratio in the progeny of mothers with toxemia of pregnancy. J Reprod Med 16:299, 1976. 4. Scott JR, Beer AE: Immunologic aspects of preeclampsia . Am J Obstet Gynecol 125:418, 1976. 5. Scott JS, Jenkins DM: Immunogenetic factors in aetiology of pre-eclampsia-eclampsia (gestosis) . J Med Genet 13:200, 1976.Crossref

Journal

JAMAAmerican Medical Association

Published: Nov 8, 1976

There are no references for this article.