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Immunobiological Significance of the Ro/SSA Antigen-Antibody System

Immunobiological Significance of the Ro/SSA Antigen-Antibody System Abstract A humoral autoimmune response to the Ro/SSA (anti-Sjögren's syndrome A) antigen is seen in several disease states that involve the skin. Circulating anti-Ro/SSA antibodies can be found in the majority of patients with primary Sjögren's syndrome,1 neonatal lupus erythematosus (LE) and congenital heart block,2-4 "ANA negative" systemic LE,5,6 subacute cutaneous LE,7 and C2 deficiency.8,9 Antibodies to the related La/SSB (anti-Sjögren's syndrome B) antigen also occur in these disorders, but in a much lower frequency. There are a number of unresolved, clinically relevant issues that pertain to the immunobiology of the small cellular ribonucleoprotein particles that have recently been identified by using these autoantibodies as probes. In this issue of the Archives, Wermuth and co-workers10 present data that address one of these issues—the subcellular localization of the Ro/SSA particle. I would like to take the opportunity to review some of the literature pertaining to this and References 1. Alspaugh MA, Tan EM: Antibodies to cellular antigens in Sjögren's syndrome . J Clin Invest 1975;55:1067-1073.Crossref 2. Franco HL, Weston WL, Peebles C, et al: Autoantibodies directed against sicca syndrome antigens in the neonatal lupus syndrome . J Am Acad Dermatol 1981;4:67-72.Crossref 3. Kephart DC, Hood AF, Provost TT: Neonatal lupus erythematosus: New serologic findings . J Invest Dermatol 1981;77:331-333.Crossref 4. Miyagawa S, Kitamura W, Yoshioka J, et al: Placental transfer of the anticytoplasmic antibodies in annular erythema of newborns . Arch Dermatol 1981;117:569-572.Crossref 5. Provost TT, Ahmed AR, Maddison PJ, et al: Antibodies to cytoplasmic antigens in lupus erythematosus: Serologic markers for systemic disease . Arthritis Rheum 1977;20:1457-1463.Crossref 6. Maddison PJ, Provost TT, Reichlin M: Serological findings in patients with `ANA-negative' systemic lupus erythematosus . Medicine 1981;60:87-94.Crossref 7. Sontheimer RD, Maddison PJ, Reichlin M, et al: Serologic and HLA associations in subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus . Ann Intern Med 1982;97:664-671.Crossref 8. Vandersteen PR, Provost TT, Jordon RE, et al: C2 deficient systemic lupus erythematosus . Arch Dermatol 1982;118:584-587.Crossref 9. Provost TT, Arnett FC, Reichlin M: Homozygous C2 deficiency, lupus erythematosus, and anti-Ro(SS-A) antibodies . Arthritis Rheum 1983;26:1279-1281.Crossref 10. Wermuth DJ, Geoghegan WD, Jordon RE: Anti-Ro/SSA antibodies: Association with a particulate (large speckledlike thread) immunofluorescent nuclear staining pattern . Arch Dermatol 1985;121:335-338.Crossref 11. Clark G, Reichlin M, Thomas TB Jr: Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythematosus . J Immunol 1969;102:117-122. 12. Alspaugh M, Maddison PJ: Resolution of identity of certain antigen-antibody systems in systemic lupus erythematosus and Sjögren's syndrome . Arthritis Rheum 1979;22:796-798.Crossref 13. Lerner MR, Boyle JA, Hardin JA, et al: Two novel classes of small ribonucleo proteins detected by antibodies associated with lupus erythematosus . Science 1981;211:400-402.Crossref 14. Venables PJ, Smith PR, Maini RN: Purification and characterization of the Sjögren's syndrome A and B antigens . Clin Exp Immunol 1983;54:731-738. 15. Wolin SL, Steitz JA: The Ro small cytoplasmic proteins: Identification of the antigenic protein and its binding site on the Ro RNAs . Proc Natl Acad Sci USA 1984;81:1996-2000.Crossref 16. Lieu TS, Jaing M, Steigerwald JC, et al: Identification of the SS-A/Ro intracellular antigen with autoimmune sera . J Immunol Methods 1984;71:217-228.Crossref 17. Elkon KB, Culhane L: Partial immunochemical characterization of the Ro and La proteins using antibodies from patients with the sicca syndrome and lupus erythematosus . J Immunol 1984;132:2350-2356. 18. Deng JS, Sontheimer RD, Gilliam JN: Molecular characteristics of SS-B/La and SS-A/Ro cellular antigens . J Invest Dermatol , in press. 19. Hendrick JP, Wolin SL, Rinke J, et al: Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: Further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells . Mol Cell Biol 1981;1:1138-1149. 20. Kato N, Hoshino H, Harada F: Nucleotide sequence of 4.55 RNA (C8 or hY5) from HeLa cells . Biochem Biophys Res Commun 1982;108:363-370.Crossref 21. Wolin SL, Steitz JA: Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome . Cell 1983;32:735-744.Crossref 22. Harmon CE, Deng JS, Peebles CL, et al: The importance of tissue substrate in the SS-A/Ro antigen-antibody system . Arthritis Rheum 1984;27:166-173.Crossref 23. Alspaugh MA, Talal N, Tan EM: Differentiation and characterization of autoantibodies and their antigens in Sjögren's syndrome . Arthritis Rheum 1976;19:216-222.Crossref 24. Dore N, Synkowski D, Provost TT: Antinuclear antibody determinations in Ro(SS-A)-positive, antinuclear antibody-negative lupus and Sjögren's syndrome patients . J Am Acad Dermatol 1983;8:611-615.Crossref 25. Burnham TK, Bank PW: Antinuclear antibodies: I. Patterns of nuclear immunofluorescence . J Invest Dermatol 1974;62:526-534.Crossref 26. Chang JY, Deng JS, Sontheimer RD, et al: Development and characterization of a monoclonal anti-SS-A/Ro antibody, abstracted . J Invest Dermatol 1984;82:390. 27. Norris DA, Ryan SR, Fritz KA, et al: The role of RNP, Sm, and SSA-specific antisera from patients with lupus erythematosus in inducing antibody dependent cellular cytotoxicity of ribonucleoprotein-coated targets, abstracted . Clin Res 1982;30:264A. 28. LeFeber WP, Norris DA, Huff JC, et al: Induction of nuclear antigen expression in human keratinocytes by ultraviolet light, abstracted . J Invest Dermatol 1983;80:328. 29. Lee N, Norris D, Surbrugg S, et al: An animal model for antibody deposition in cutaneous lupus, abstracted . J Invest Dermatol 1984;82:427. 30. Lee LA, Harmon CE, Huff JC, et al: SSA(Ro) antigen expression in human fetal, neonatal and adult tissues, abstracted . Arthritis Rheum 1984;27:S20.Crossref 31. Harmon CE, Lee LA, Huff JC, et al: The frequency of antibodies to the SS-A/Ro antigen in pregnancy sera, abstracted . Arthritis Rheum 1984;27:S20.Crossref 32. Callen JP, Fowler JF, Kulick JB, et al: Neonatal lupus erythematosus: Discordant disease expression in fraternal twins: Serologic and immunogenetic studies, abstracted . Arthritis Rheum 1984;27:S62. 33. Alarcón-Segovia D, Ruiz-Arguelles A, Fishbein E: Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc-receptors . Nature 1978;271:67-69.Crossref 34. Alarcón-Segovia D, Ruiz-Arguelles A, Llorente L: Antibody penetration into living cells: II. Antiribonucleoprotein IgG penetrates into Tγ lymphocytes causing their deletion and their abrogation of suppressor function . J Immunol 1979;122:1855-1862. 35. Bell DA, Maddison PJ: An examination of autoantibodies in relationship to clinical features of disease and HLA antigens . Arthritis Rheum 1980;23:1268-1273.Crossref 36. Marsh DG, Meyers DA, Freidhoff LR, et al: Association of HLA phenotypes Al, B8, DW3 and A3, B7, BW2 with allergy, abstracted . Fed Proc 1980;39:936. 37. Lawley TJ, Hall RP, Fauci AS, et al: Defective Fc receptor functions associated with the HLA-B8/DR3 haplotype . N Engl J Med 1980;304:185-192.Crossref 38. Ambinder JM, Chiazzi N, Gibofsky A, et al: Special characteristics of cellular immune function in normal individuals of the HLA DR3 type . Clin Immunol Immunopathol 1984;23:269-274.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Immunobiological Significance of the Ro/SSA Antigen-Antibody System

Archives of Dermatology , Volume 121 (3) – Mar 1, 1985

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660030049015
Publisher site
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Abstract

Abstract A humoral autoimmune response to the Ro/SSA (anti-Sjögren's syndrome A) antigen is seen in several disease states that involve the skin. Circulating anti-Ro/SSA antibodies can be found in the majority of patients with primary Sjögren's syndrome,1 neonatal lupus erythematosus (LE) and congenital heart block,2-4 "ANA negative" systemic LE,5,6 subacute cutaneous LE,7 and C2 deficiency.8,9 Antibodies to the related La/SSB (anti-Sjögren's syndrome B) antigen also occur in these disorders, but in a much lower frequency. There are a number of unresolved, clinically relevant issues that pertain to the immunobiology of the small cellular ribonucleoprotein particles that have recently been identified by using these autoantibodies as probes. In this issue of the Archives, Wermuth and co-workers10 present data that address one of these issues—the subcellular localization of the Ro/SSA particle. I would like to take the opportunity to review some of the literature pertaining to this and References 1. Alspaugh MA, Tan EM: Antibodies to cellular antigens in Sjögren's syndrome . J Clin Invest 1975;55:1067-1073.Crossref 2. Franco HL, Weston WL, Peebles C, et al: Autoantibodies directed against sicca syndrome antigens in the neonatal lupus syndrome . J Am Acad Dermatol 1981;4:67-72.Crossref 3. Kephart DC, Hood AF, Provost TT: Neonatal lupus erythematosus: New serologic findings . J Invest Dermatol 1981;77:331-333.Crossref 4. Miyagawa S, Kitamura W, Yoshioka J, et al: Placental transfer of the anticytoplasmic antibodies in annular erythema of newborns . Arch Dermatol 1981;117:569-572.Crossref 5. Provost TT, Ahmed AR, Maddison PJ, et al: Antibodies to cytoplasmic antigens in lupus erythematosus: Serologic markers for systemic disease . Arthritis Rheum 1977;20:1457-1463.Crossref 6. Maddison PJ, Provost TT, Reichlin M: Serological findings in patients with `ANA-negative' systemic lupus erythematosus . Medicine 1981;60:87-94.Crossref 7. Sontheimer RD, Maddison PJ, Reichlin M, et al: Serologic and HLA associations in subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus . Ann Intern Med 1982;97:664-671.Crossref 8. Vandersteen PR, Provost TT, Jordon RE, et al: C2 deficient systemic lupus erythematosus . Arch Dermatol 1982;118:584-587.Crossref 9. Provost TT, Arnett FC, Reichlin M: Homozygous C2 deficiency, lupus erythematosus, and anti-Ro(SS-A) antibodies . Arthritis Rheum 1983;26:1279-1281.Crossref 10. Wermuth DJ, Geoghegan WD, Jordon RE: Anti-Ro/SSA antibodies: Association with a particulate (large speckledlike thread) immunofluorescent nuclear staining pattern . Arch Dermatol 1985;121:335-338.Crossref 11. Clark G, Reichlin M, Thomas TB Jr: Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythematosus . J Immunol 1969;102:117-122. 12. Alspaugh M, Maddison PJ: Resolution of identity of certain antigen-antibody systems in systemic lupus erythematosus and Sjögren's syndrome . Arthritis Rheum 1979;22:796-798.Crossref 13. Lerner MR, Boyle JA, Hardin JA, et al: Two novel classes of small ribonucleo proteins detected by antibodies associated with lupus erythematosus . Science 1981;211:400-402.Crossref 14. Venables PJ, Smith PR, Maini RN: Purification and characterization of the Sjögren's syndrome A and B antigens . Clin Exp Immunol 1983;54:731-738. 15. Wolin SL, Steitz JA: The Ro small cytoplasmic proteins: Identification of the antigenic protein and its binding site on the Ro RNAs . Proc Natl Acad Sci USA 1984;81:1996-2000.Crossref 16. Lieu TS, Jaing M, Steigerwald JC, et al: Identification of the SS-A/Ro intracellular antigen with autoimmune sera . J Immunol Methods 1984;71:217-228.Crossref 17. Elkon KB, Culhane L: Partial immunochemical characterization of the Ro and La proteins using antibodies from patients with the sicca syndrome and lupus erythematosus . J Immunol 1984;132:2350-2356. 18. Deng JS, Sontheimer RD, Gilliam JN: Molecular characteristics of SS-B/La and SS-A/Ro cellular antigens . J Invest Dermatol , in press. 19. Hendrick JP, Wolin SL, Rinke J, et al: Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: Further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells . Mol Cell Biol 1981;1:1138-1149. 20. Kato N, Hoshino H, Harada F: Nucleotide sequence of 4.55 RNA (C8 or hY5) from HeLa cells . Biochem Biophys Res Commun 1982;108:363-370.Crossref 21. Wolin SL, Steitz JA: Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome . Cell 1983;32:735-744.Crossref 22. Harmon CE, Deng JS, Peebles CL, et al: The importance of tissue substrate in the SS-A/Ro antigen-antibody system . Arthritis Rheum 1984;27:166-173.Crossref 23. Alspaugh MA, Talal N, Tan EM: Differentiation and characterization of autoantibodies and their antigens in Sjögren's syndrome . Arthritis Rheum 1976;19:216-222.Crossref 24. Dore N, Synkowski D, Provost TT: Antinuclear antibody determinations in Ro(SS-A)-positive, antinuclear antibody-negative lupus and Sjögren's syndrome patients . J Am Acad Dermatol 1983;8:611-615.Crossref 25. Burnham TK, Bank PW: Antinuclear antibodies: I. Patterns of nuclear immunofluorescence . J Invest Dermatol 1974;62:526-534.Crossref 26. Chang JY, Deng JS, Sontheimer RD, et al: Development and characterization of a monoclonal anti-SS-A/Ro antibody, abstracted . J Invest Dermatol 1984;82:390. 27. Norris DA, Ryan SR, Fritz KA, et al: The role of RNP, Sm, and SSA-specific antisera from patients with lupus erythematosus in inducing antibody dependent cellular cytotoxicity of ribonucleoprotein-coated targets, abstracted . Clin Res 1982;30:264A. 28. LeFeber WP, Norris DA, Huff JC, et al: Induction of nuclear antigen expression in human keratinocytes by ultraviolet light, abstracted . J Invest Dermatol 1983;80:328. 29. Lee N, Norris D, Surbrugg S, et al: An animal model for antibody deposition in cutaneous lupus, abstracted . J Invest Dermatol 1984;82:427. 30. Lee LA, Harmon CE, Huff JC, et al: SSA(Ro) antigen expression in human fetal, neonatal and adult tissues, abstracted . Arthritis Rheum 1984;27:S20.Crossref 31. Harmon CE, Lee LA, Huff JC, et al: The frequency of antibodies to the SS-A/Ro antigen in pregnancy sera, abstracted . Arthritis Rheum 1984;27:S20.Crossref 32. Callen JP, Fowler JF, Kulick JB, et al: Neonatal lupus erythematosus: Discordant disease expression in fraternal twins: Serologic and immunogenetic studies, abstracted . Arthritis Rheum 1984;27:S62. 33. Alarcón-Segovia D, Ruiz-Arguelles A, Fishbein E: Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc-receptors . Nature 1978;271:67-69.Crossref 34. Alarcón-Segovia D, Ruiz-Arguelles A, Llorente L: Antibody penetration into living cells: II. Antiribonucleoprotein IgG penetrates into Tγ lymphocytes causing their deletion and their abrogation of suppressor function . J Immunol 1979;122:1855-1862. 35. Bell DA, Maddison PJ: An examination of autoantibodies in relationship to clinical features of disease and HLA antigens . Arthritis Rheum 1980;23:1268-1273.Crossref 36. Marsh DG, Meyers DA, Freidhoff LR, et al: Association of HLA phenotypes Al, B8, DW3 and A3, B7, BW2 with allergy, abstracted . Fed Proc 1980;39:936. 37. Lawley TJ, Hall RP, Fauci AS, et al: Defective Fc receptor functions associated with the HLA-B8/DR3 haplotype . N Engl J Med 1980;304:185-192.Crossref 38. Ambinder JM, Chiazzi N, Gibofsky A, et al: Special characteristics of cellular immune function in normal individuals of the HLA DR3 type . Clin Immunol Immunopathol 1984;23:269-274.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1985

References