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IMMUNIZATION AGAINST DIPHTHERIA WITH TOXOID

IMMUNIZATION AGAINST DIPHTHERIA WITH TOXOID It is not my purpose to discuss the relative merits of toxin-antitoxin and toxoid. This phase has been thoroughly investigated by Ramon and Helie,1 Zingher,2 Bloomberg and Fleming,3 Mozer,4 Harrison5 and more recently in this clinic by Weinfeld and Cooperstock6 and other observers (table 1). The conclusions arrived at by these workers are that toxoid is superior to toxin-antitoxin for the following reasons: 1. Sensitization to horse serum is eliminated. 2. The solution is more stable. 3. Fewer injections are needed. 4. The immunizing power is greater and more rapid. The original technic as described by Ramon and Helie1 is as follows: "An initial dose of 0.5 cc. of anatoxin is injected subcutaneously; three weeks later 1.0 cc. is injected, and in many cases if not all, a third injection of from 1.0 cc. to 1.5 cc. is given fifteen days after the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

IMMUNIZATION AGAINST DIPHTHERIA WITH TOXOID

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1932 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1932.01950130099007
Publisher site
See Article on Publisher Site

Abstract

It is not my purpose to discuss the relative merits of toxin-antitoxin and toxoid. This phase has been thoroughly investigated by Ramon and Helie,1 Zingher,2 Bloomberg and Fleming,3 Mozer,4 Harrison5 and more recently in this clinic by Weinfeld and Cooperstock6 and other observers (table 1). The conclusions arrived at by these workers are that toxoid is superior to toxin-antitoxin for the following reasons: 1. Sensitization to horse serum is eliminated. 2. The solution is more stable. 3. Fewer injections are needed. 4. The immunizing power is greater and more rapid. The original technic as described by Ramon and Helie1 is as follows: "An initial dose of 0.5 cc. of anatoxin is injected subcutaneously; three weeks later 1.0 cc. is injected, and in many cases if not all, a third injection of from 1.0 cc. to 1.5 cc. is given fifteen days after the

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Dec 1, 1932

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