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P. Moloney, C. Fraser (1927)
IMMUNIZATION WITH DIPHTHERIA TOXOID (ANATOXINE RAMON).American journal of public health, 17 10
J. Greengard (1931)
DIPHTHERIA TOXOID (DIPHTHERIA ANATOXIN-RAMON) IN INFANCYJAMA, 97
M. Cooperstock, G. Weinfeld (1930)
RAPIDITY OF IMMUNIZATION WITH DIPHTHERIA TOXOIDJAMA Pediatrics, 40
W. Harrison
The Immunizing Value of Diphtheria Toxin-Antitoxin Mixture and of Diphtheria Toxoid.Public Health Reports, 45
G. Dick, G. Dick (1929)
IMMUNIZATION AGAINST DIPHTHERIA: COMPARATIVE VALUE OF TOXOID AND TOXINANTITOXIN MIXTURESJAMA, 92
A. Glenny (1925)
The Principles of Immunity applied to Protective Inoculation against DiphtheriaEpidemiology and Infection, 24
D. Cowie (1916)
OBSERVATIONS ON THE INTRADERMAL AND REPEATED INTRADERMAL INJECTION OF DIPHTHERIA TOXIN WITH REFERENCE TO THE SCHICK TESTJAMA Pediatrics
G. Ramon, G. Hélie (1928)
DIPHTHERIA PROPHYLAXIS IN FRANCE: EXPERIMENTS WITH ANATOXIN VACCINATIONJAMA, 91
G. Weinfeld, M. Cooperstock (1929)
Comparative Effects of Diphtheria Toxoid and Toxin-Antitoxin as Immunizing Agents.JAMA Pediatrics, 38
It is not my purpose to discuss the relative merits of toxin-antitoxin and toxoid. This phase has been thoroughly investigated by Ramon and Helie,1 Zingher,2 Bloomberg and Fleming,3 Mozer,4 Harrison5 and more recently in this clinic by Weinfeld and Cooperstock6 and other observers (table 1). The conclusions arrived at by these workers are that toxoid is superior to toxin-antitoxin for the following reasons: 1. Sensitization to horse serum is eliminated. 2. The solution is more stable. 3. Fewer injections are needed. 4. The immunizing power is greater and more rapid. The original technic as described by Ramon and Helie1 is as follows: "An initial dose of 0.5 cc. of anatoxin is injected subcutaneously; three weeks later 1.0 cc. is injected, and in many cases if not all, a third injection of from 1.0 cc. to 1.5 cc. is given fifteen days after the
American journal of diseases of children – American Medical Association
Published: Dec 1, 1932
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