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Immunity to Chlamydial Infections of the Eye: IV. Immunity in Owl Monkeys to Reinfection With Trachoma

Immunity to Chlamydial Infections of the Eye: IV. Immunity in Owl Monkeys to Reinfection With... Abstract In a study of trachoma in owl monkeys, it was found that owl monkeys are equally susceptible to low and high doses of trachoma and that resistance to reinfection persisted for six months in the majority of animals. Previous infections with a single trachoma type did not elicit greater resistance than previous infections with two types. Both serum antibodies and eye secretion titers correlated well with resistance to reinfection, but it is not as yet clear if either or both play a substantial role in immunity to trachoma. References 1. Bell SD, Fraser CEO: Experimental trachoma in owl monkeys . Am J Trop Med Hyg 18:568-572, 1969. 2. Fraser CEO, Bell SD: Experimental trachoma in owl monkeys and Taiwan monkeys , in Goldsmith EI, Moore-Jankowski J (eds): Medical Primatology, 1970 . New York, S. Karger, 1971, pp 783-791. 3. Murray ES, Fraser CEO, Peters JH, et al: The owl monkey as an experimental primate model for conjunctival trachoma infection , in Nichols RL (ed): Trachoma and Related Disorders Caused by Chlamydial Agents . Princeton, NJ, Excerpta Medica, ICS No. 223, 1971, pp 387-395. 4. Bell SD, McComb DE: Differentiation of trachoma bedsoniae in vitro . Proc Soc Exp Biol Med 124:34-39, 1967.Crossref 5. Nichols RL, Bobb AA, Haddad NA, et al: Immunofluorescent studies of the microbiologic epidemiology of trachoma in Saudi Arabia . Am J Ophthalmol 63:1372-1408, 1967. 6. McComb DE, Nichols RL: Antibodies to trachoma in eye secretions of Saudi Arab children . Am J Epidemiol 90:278-284, 1969. 7. McComb DE, Peters JH, Fraser CEO, et al: Resistance to trachoma infection in owl monkeys correlated with antibody status at the outset in an experiment to test the response to topical trachoma antigens , in Nichols RL (ed): Trachoma and Related Disorders Caused by Chlamydial Agents . Princeton, NJ, Excerpta Medica, ICS No. 223, 1971, pp 396-406. 8. Orenstein NS, Mull JD, Thompson SE: Immunity to chlamydial infections of the eye: V. Passive transfer of antitrachoma antibodies to owl monkeys . Infect Immunol 7:600-603, 1973. 9. Watson RR, Mull JD, MacDonald AB, et al: Immunity to chlamydial infections of the eye: II. Studies of passively transferred serum antibody in resistance to infection with guinea pig inclusion conjunctivitis . Infect Immunol 7:597-599, 1973. 10. Murray ES, Charbonnet LT, MacDonald AB: Immunity to chlamydial infections of the eye: I. The role of circulatory and secretory antibodies in resistance to reinfection with guinea pig inclusion conjunctivitis . J Immunol 110:1518-1525, 1973. 11. Murray ES, Charbonnet LT: Experimental conjunctival infection of guinea pigs with the guinea pig inclusion conjunctivitis organism , in Nichols RL: Trachoma and Related Disorders Caused by Chlamydial Agents . Princeton, NJ, Excerpta Medica, ICS No. 223, 1971, pp 369-376. 12. Nichols RL, Oertley RE, Fraser CEO, et al: Immunity to chlamydial infections of the eye: VI. Neutralization of trachoma infectivity for the owl monkey conjunctivae by eye secretions from human trachoma cases . J Infect Dis 127:429-432, 1973.Crossref 13. Barenfanger J, MacDonald AB: The role of immunoglobulins derived from human eye secretions in the neutralization of trachoma infectivity. J Immunol, to be published. 14. Watson RR, MacDonald AB, Murray ES, et al: Immunity to chlamydial infections of the eye: III. Presence and duration of delayed hypersensitivity to guinea pig inclusion conjunctivitis . J Immunol 111:618-623, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Immunity to Chlamydial Infections of the Eye: IV. Immunity in Owl Monkeys to Reinfection With Trachoma

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1975.01010020534010
Publisher site
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Abstract

Abstract In a study of trachoma in owl monkeys, it was found that owl monkeys are equally susceptible to low and high doses of trachoma and that resistance to reinfection persisted for six months in the majority of animals. Previous infections with a single trachoma type did not elicit greater resistance than previous infections with two types. Both serum antibodies and eye secretion titers correlated well with resistance to reinfection, but it is not as yet clear if either or both play a substantial role in immunity to trachoma. References 1. Bell SD, Fraser CEO: Experimental trachoma in owl monkeys . Am J Trop Med Hyg 18:568-572, 1969. 2. Fraser CEO, Bell SD: Experimental trachoma in owl monkeys and Taiwan monkeys , in Goldsmith EI, Moore-Jankowski J (eds): Medical Primatology, 1970 . New York, S. Karger, 1971, pp 783-791. 3. Murray ES, Fraser CEO, Peters JH, et al: The owl monkey as an experimental primate model for conjunctival trachoma infection , in Nichols RL (ed): Trachoma and Related Disorders Caused by Chlamydial Agents . Princeton, NJ, Excerpta Medica, ICS No. 223, 1971, pp 387-395. 4. Bell SD, McComb DE: Differentiation of trachoma bedsoniae in vitro . Proc Soc Exp Biol Med 124:34-39, 1967.Crossref 5. Nichols RL, Bobb AA, Haddad NA, et al: Immunofluorescent studies of the microbiologic epidemiology of trachoma in Saudi Arabia . Am J Ophthalmol 63:1372-1408, 1967. 6. McComb DE, Nichols RL: Antibodies to trachoma in eye secretions of Saudi Arab children . Am J Epidemiol 90:278-284, 1969. 7. McComb DE, Peters JH, Fraser CEO, et al: Resistance to trachoma infection in owl monkeys correlated with antibody status at the outset in an experiment to test the response to topical trachoma antigens , in Nichols RL (ed): Trachoma and Related Disorders Caused by Chlamydial Agents . Princeton, NJ, Excerpta Medica, ICS No. 223, 1971, pp 396-406. 8. Orenstein NS, Mull JD, Thompson SE: Immunity to chlamydial infections of the eye: V. Passive transfer of antitrachoma antibodies to owl monkeys . Infect Immunol 7:600-603, 1973. 9. Watson RR, Mull JD, MacDonald AB, et al: Immunity to chlamydial infections of the eye: II. Studies of passively transferred serum antibody in resistance to infection with guinea pig inclusion conjunctivitis . Infect Immunol 7:597-599, 1973. 10. Murray ES, Charbonnet LT, MacDonald AB: Immunity to chlamydial infections of the eye: I. The role of circulatory and secretory antibodies in resistance to reinfection with guinea pig inclusion conjunctivitis . J Immunol 110:1518-1525, 1973. 11. Murray ES, Charbonnet LT: Experimental conjunctival infection of guinea pigs with the guinea pig inclusion conjunctivitis organism , in Nichols RL: Trachoma and Related Disorders Caused by Chlamydial Agents . Princeton, NJ, Excerpta Medica, ICS No. 223, 1971, pp 369-376. 12. Nichols RL, Oertley RE, Fraser CEO, et al: Immunity to chlamydial infections of the eye: VI. Neutralization of trachoma infectivity for the owl monkey conjunctivae by eye secretions from human trachoma cases . J Infect Dis 127:429-432, 1973.Crossref 13. Barenfanger J, MacDonald AB: The role of immunoglobulins derived from human eye secretions in the neutralization of trachoma infectivity. J Immunol, to be published. 14. Watson RR, MacDonald AB, Murray ES, et al: Immunity to chlamydial infections of the eye: III. Presence and duration of delayed hypersensitivity to guinea pig inclusion conjunctivitis . J Immunol 111:618-623, 1973.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1975

References