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IgE Antibodies to Staphylococcus aureus: Prevalence in Patients With Atopic Dermatitis

IgE Antibodies to Staphylococcus aureus: Prevalence in Patients With Atopic Dermatitis Abstract • We determined the prevalence of IgE antibodies to Staphylococcus aureus by optimized immunoradiometric assay methods in serum specimens from 69 patients with atopic dermatitis. All patients had positive aerobic cultures for S aureus from skin. Significant binding attributable to IgE antibodies was noted in three of 25 patients with atopic dermatitis and superimposed impetiginization or pustules, but antibodies were not detected in the remaining 44 patients whose lesions were colonized with S aureus. By comparison, IgE antibodies to S aureus were uniformly present in high titer in serum samples from patients with the hyperimmunoglobulin E syndrome. We conclude that most patients with atopic dermatitis do not have detectable levels of IgE antibodies to S aureus. (Arch Dermatol 1985;121:869-872) References 1. Schopfer K, Baerlocher K, Price P, et al: Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and Staphylococcus aureus infections . N Engl J Med 1979;300:835-838.Crossref 2. Schopfer K, Douglas SD, Wilkinson BS: Immunoglobulin E antibodies against Staphylococcus aureus cell walls in the sera of patients with hyperimmunoglobulinemia E and recurrent staphylococcal infections . Infect Immun 1980;27:563-568. 3. Berger M, Kirkpatrick CH, Goldsmith PK, et al: IgE antibodies to S aureus and C albicans in patients with the syndrome of hyperimmunoglobulin E and recurrent infections . J Immunol 1980;125:2437-2443. 4. Henocq E, Hewitt B, Guerin B: Staphylococcal and human dander IgE antibodies in superinfected atopic dermatitis . Clin Allergy 1982;12:113-120.Crossref 5. Walsh GA, Richards KL, Douglas SD, et al: Immunoglobulin E anti-Staphylococcus aureus antibodies in atopic dermatitis . J Clin Microbiol 1981;13:1046-1048. 6. Abrahamson JS, Dahl MV, Walsh G, et al: Antistaphylococcal IgE in patients with atopic dermatitis . J Am Acad Dermatol 1982;7:105-110.Crossref 7. Friedman SJ, Schroeter AL, Homburger HA: Whole organisms and purified cell walls compared as immunosorbents for the detection of IgE antibodies to Staphylococcus aureus . J Immunol Methods 1984;66:369-375.Crossref 8. Dahl MV: Staphylococcus aureus with atopic dermatitis . Arch Dermatol 1983;119:840-846.Crossref 9. Donabedian H, Gallin JI: Two inhibitors of neutrophil chemotaxis are produced by hyperimmunoglobulin E recurrent infection syndrome mononuclear cells exposed to heat-killed staphylococci . Infect Immun 1983;40:1030-1037. 10. Berg T, Bennich H, Johansson SGO: In vitro diagnosis of atopic allergy: I. A comparison between provocation tests and the radioallergosorbent test . Int Arch Allergy Appl Immunol 1971;40:770-778.Crossref 11. Kronvall G, Gewurz H: Activation and inhibition of IgG mediated complement fixation of staphylococcal protein A . Clin Exp Immunol 1970;7:211-220. 12. Petersson BA, Stalenheim G: Induction of histamine release and sensitization in human leukocytes. Effect of anti-IgE and protein-A from S aureus . Scand J Immunol 1975;4:103-112.Crossref 13. Inganas M, Johansson SGO, Bennich HH: Interaction of human polyclonal IgE and IgG from different species with protein A and S aureus: Demonstration of protein A reactive sites located in the Fab, fragment of human IgG . Scand J Immunol 1980;12:23-31.Crossref 14. Johansson SGO, Inganas M: Interaction of polyclonal human IgE with protein A from S aureus . Immunol Rev 1978;41:248-260.Crossref 15. Wachs GN, Maibach HI: Co-operative double blind trial of an antibiotic/corticoid combination in impetiginized atopic dermatitis . Br J Dermatol 1976;95:323-328.Crossref 16. Leyden JJ, Kligman AM: The case for steroid-antibiotic combinations . Br J Dermatol 1977;96:179-187.Crossref 17. Steroid-antibiotic combination, editorial . Br Med J 1977;1:1303-1304. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

IgE Antibodies to Staphylococcus aureus: Prevalence in Patients With Atopic Dermatitis

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660070059015
Publisher site
See Article on Publisher Site

Abstract

Abstract • We determined the prevalence of IgE antibodies to Staphylococcus aureus by optimized immunoradiometric assay methods in serum specimens from 69 patients with atopic dermatitis. All patients had positive aerobic cultures for S aureus from skin. Significant binding attributable to IgE antibodies was noted in three of 25 patients with atopic dermatitis and superimposed impetiginization or pustules, but antibodies were not detected in the remaining 44 patients whose lesions were colonized with S aureus. By comparison, IgE antibodies to S aureus were uniformly present in high titer in serum samples from patients with the hyperimmunoglobulin E syndrome. We conclude that most patients with atopic dermatitis do not have detectable levels of IgE antibodies to S aureus. (Arch Dermatol 1985;121:869-872) References 1. Schopfer K, Baerlocher K, Price P, et al: Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and Staphylococcus aureus infections . N Engl J Med 1979;300:835-838.Crossref 2. Schopfer K, Douglas SD, Wilkinson BS: Immunoglobulin E antibodies against Staphylococcus aureus cell walls in the sera of patients with hyperimmunoglobulinemia E and recurrent staphylococcal infections . Infect Immun 1980;27:563-568. 3. Berger M, Kirkpatrick CH, Goldsmith PK, et al: IgE antibodies to S aureus and C albicans in patients with the syndrome of hyperimmunoglobulin E and recurrent infections . J Immunol 1980;125:2437-2443. 4. Henocq E, Hewitt B, Guerin B: Staphylococcal and human dander IgE antibodies in superinfected atopic dermatitis . Clin Allergy 1982;12:113-120.Crossref 5. Walsh GA, Richards KL, Douglas SD, et al: Immunoglobulin E anti-Staphylococcus aureus antibodies in atopic dermatitis . J Clin Microbiol 1981;13:1046-1048. 6. Abrahamson JS, Dahl MV, Walsh G, et al: Antistaphylococcal IgE in patients with atopic dermatitis . J Am Acad Dermatol 1982;7:105-110.Crossref 7. Friedman SJ, Schroeter AL, Homburger HA: Whole organisms and purified cell walls compared as immunosorbents for the detection of IgE antibodies to Staphylococcus aureus . J Immunol Methods 1984;66:369-375.Crossref 8. Dahl MV: Staphylococcus aureus with atopic dermatitis . Arch Dermatol 1983;119:840-846.Crossref 9. Donabedian H, Gallin JI: Two inhibitors of neutrophil chemotaxis are produced by hyperimmunoglobulin E recurrent infection syndrome mononuclear cells exposed to heat-killed staphylococci . Infect Immun 1983;40:1030-1037. 10. Berg T, Bennich H, Johansson SGO: In vitro diagnosis of atopic allergy: I. A comparison between provocation tests and the radioallergosorbent test . Int Arch Allergy Appl Immunol 1971;40:770-778.Crossref 11. Kronvall G, Gewurz H: Activation and inhibition of IgG mediated complement fixation of staphylococcal protein A . Clin Exp Immunol 1970;7:211-220. 12. Petersson BA, Stalenheim G: Induction of histamine release and sensitization in human leukocytes. Effect of anti-IgE and protein-A from S aureus . Scand J Immunol 1975;4:103-112.Crossref 13. Inganas M, Johansson SGO, Bennich HH: Interaction of human polyclonal IgE and IgG from different species with protein A and S aureus: Demonstration of protein A reactive sites located in the Fab, fragment of human IgG . Scand J Immunol 1980;12:23-31.Crossref 14. Johansson SGO, Inganas M: Interaction of polyclonal human IgE with protein A from S aureus . Immunol Rev 1978;41:248-260.Crossref 15. Wachs GN, Maibach HI: Co-operative double blind trial of an antibiotic/corticoid combination in impetiginized atopic dermatitis . Br J Dermatol 1976;95:323-328.Crossref 16. Leyden JJ, Kligman AM: The case for steroid-antibiotic combinations . Br J Dermatol 1977;96:179-187.Crossref 17. Steroid-antibiotic combination, editorial . Br Med J 1977;1:1303-1304.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1985

References