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IgA Nephropathy in Leprosy

IgA Nephropathy in Leprosy Abstract To the Editor. —Leprosy is a disease still present in some parts of Spain, where it represents a substantial health problem.Renal involvement was first described by Mitsuda and Ogawa1 in 1937, and, since then, numerous patients with amyloidosis and interstitial or glomerular nephropathies have been described, mainly in the lepromatous form of the disease. In recent randomized studies, ten (50%) of 20 patients2 and eight (23%) of 35 patients3 with lepromatous leprosy had evidence of proliferative glomerulonephritis.So far, exudative and proliferative glomerulonephritis, focal proliferative glomerulonephritis, and nonproliferative glomerulonephritis with isolated mesangial sclerosis have been described. In some cases, the histologic study has included immunofluorescent examinations that showed granular deposits of IgG and complement and sometimes IgM. Only one patient had IgA, and, in this case, IgA was not the preponderant immunoglobulin.In an attempt to contribute further to the spectrum of glomerular pathology associated with References 1. Mitsuda K, Ogawa M: A study of 150 autopsies on cases of leprosy. Int J Lepr 1937;5:53-60. 2. Çölòglu AS: Immune complex glomerulonephritis in leprosy. Lepr Rev 1979;50:213-222. 3. Johny KV, Karat ABA, Rao PSS, et al: Glomerulonephritis in leprosy: A percutaneous renal biopsy study. Lepr Rev 1975;46:29-37. 4. Shwe T, Petty RE: Activation of complement (C3) in patients with leprosy. Lepr Rev 1972;42:277-281. 5. Verroust P, Smith M, Languillon J, et al: Detection d'immunocomplex solubles circulans au cours de la lèpre et des bilharzioses. Méd Mal Infect 1975;5:625-630. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

IgA Nephropathy in Leprosy

Abstract

Abstract To the Editor. —Leprosy is a disease still present in some parts of Spain, where it represents a substantial health problem.Renal involvement was first described by Mitsuda and Ogawa1 in 1937, and, since then, numerous patients with amyloidosis and interstitial or glomerular nephropathies have been described, mainly in the lepromatous form of the disease. In recent randomized studies, ten (50%) of 20 patients2 and eight (23%) of 35 patients3 with lepromatous leprosy had...
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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340190198034
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —Leprosy is a disease still present in some parts of Spain, where it represents a substantial health problem.Renal involvement was first described by Mitsuda and Ogawa1 in 1937, and, since then, numerous patients with amyloidosis and interstitial or glomerular nephropathies have been described, mainly in the lepromatous form of the disease. In recent randomized studies, ten (50%) of 20 patients2 and eight (23%) of 35 patients3 with lepromatous leprosy had evidence of proliferative glomerulonephritis.So far, exudative and proliferative glomerulonephritis, focal proliferative glomerulonephritis, and nonproliferative glomerulonephritis with isolated mesangial sclerosis have been described. In some cases, the histologic study has included immunofluorescent examinations that showed granular deposits of IgG and complement and sometimes IgM. Only one patient had IgA, and, in this case, IgA was not the preponderant immunoglobulin.In an attempt to contribute further to the spectrum of glomerular pathology associated with References 1. Mitsuda K, Ogawa M: A study of 150 autopsies on cases of leprosy. Int J Lepr 1937;5:53-60. 2. Çölòglu AS: Immune complex glomerulonephritis in leprosy. Lepr Rev 1979;50:213-222. 3. Johny KV, Karat ABA, Rao PSS, et al: Glomerulonephritis in leprosy: A percutaneous renal biopsy study. Lepr Rev 1975;46:29-37. 4. Shwe T, Petty RE: Activation of complement (C3) in patients with leprosy. Lepr Rev 1972;42:277-281. 5. Verroust P, Smith M, Languillon J, et al: Detection d'immunocomplex solubles circulans au cours de la lèpre et des bilharzioses. Méd Mal Infect 1975;5:625-630.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1982

References