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IDU Therapy of Herpes Simplex

IDU Therapy of Herpes Simplex Abstract To date, there has been no well-documented description of effective therapy for any "true" viral disease, although the Chlamydozoaceae, the very large viruses, are sensitive to ordinary broad-spectrum antibiotics. To be sure, many agents, such as specific antibody or interferon, prevent the appearance of viral disease in vitro and in vivo. None of these, however, has cured or improved viral disease once it was present. Present therapy of herpes simplex keratitis with debriding agents, though helpful, is by no means uniformly satisfactory and does not eliminate virus.1 This communication will report the use of a drug, 5-iodo-2'-deoxyuridine (IDU), a viral antibiotic which cures or ameliorates experimental herpes simplex keratitis,2 even after the keratitis is extensive and severe. Methods and Materials The corneas of albino rabbits were traumatized by 3 interlocking circles in the central cornea made with a 5 mm. trephine set to a depth of 0.05 mm. References 1. Powder was obtained from Nutritional Biochemical Corporation. Drops are now made by Smith, Kline & French Laboratories, 1500 Spring Garden St., Philadelphia. 2. Kaufman, H. E., and Howard G. M.: Therapy of Experimental Herpes Simplex Keratitis, Invest. Ophthal., to be published. 3. Kaufman, H. E.: Clinical Cure of Herpes Simplex Keratitis by 5-Iodo-2'-Deoxyuridine, Proc. Soc. Exp. Biol. Med., to be published. 4. Kaufman, H. E., and Maloney, E. D.: Experimental Herpes Simplex Keratitis: Effect of Corticosteroids and Epithelial Curettage , Arch. Ophthal. 66:99, 1961.Crossref 5. Tamm, I.: Symposium on the Experimental Pharmacology and Clinical Use of Antimetabolites: III. Metabolic Antagonists and Selective Virus Inhibition , Clin. Pharmacol. Therap. 1:777, 1960. 6. Herrmann, E. C., Jr.: Plaque Inhibition Test for Detection of Specific Inhibitors of DNA Containing Viruses , Proc. Soc. Exp. Biol. Med. 107:142, 1961.Crossref 7. Stocker, M. G. P.: Growth Studies with Herpes Virus , in Virus Growth and Variation: A Symposium , edited by Isaacs, A., and Lacey, B. W., London, Cambridge University Press, 1959. 8. Howard, G. M., and Kaufman, H. E.: Review of Herpes Simplex Keratitis , Arch. Ophthal. 67: 373, 1962.Crossref 9. Gundersen, T.: Herpes Corneae: With Special References to Its Treatment with Strong Solution of Iodine , Arch. Ophthal. 15:225, 1936.Crossref 10. Welch, A. D., and Prusoff, W. H.: Synopsis of Recent Investigations of 5-Iodo-2'-Deoxyuridine, Cancer Chemother. (Rep. 6) p. 29, 1960. 11. Goodman, L., and Gilman, A.: Pharmacological Basis of Therapeutics , New York, The Macmillan Company, 1955, pp. 1276-1317. 12. Goodman, L., and Gilman, A.,10 pp. 1394-1399. 13. Goodman, L., and Gilman, A.,10 pp. 1324-1357. 14. Goodman, L., and Gilman, A.,10 pp. 1182-1183. 15. Kaufman, H. E.; Martola, E-L., and Dohlman, C-H.: The Use of a New Viral Antibiotic in the Treatment of Herpes Simplex Keratitis, in preparation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

IDU Therapy of Herpes Simplex

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960020583012
Publisher site
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Abstract

Abstract To date, there has been no well-documented description of effective therapy for any "true" viral disease, although the Chlamydozoaceae, the very large viruses, are sensitive to ordinary broad-spectrum antibiotics. To be sure, many agents, such as specific antibody or interferon, prevent the appearance of viral disease in vitro and in vivo. None of these, however, has cured or improved viral disease once it was present. Present therapy of herpes simplex keratitis with debriding agents, though helpful, is by no means uniformly satisfactory and does not eliminate virus.1 This communication will report the use of a drug, 5-iodo-2'-deoxyuridine (IDU), a viral antibiotic which cures or ameliorates experimental herpes simplex keratitis,2 even after the keratitis is extensive and severe. Methods and Materials The corneas of albino rabbits were traumatized by 3 interlocking circles in the central cornea made with a 5 mm. trephine set to a depth of 0.05 mm. References 1. Powder was obtained from Nutritional Biochemical Corporation. Drops are now made by Smith, Kline & French Laboratories, 1500 Spring Garden St., Philadelphia. 2. Kaufman, H. E., and Howard G. M.: Therapy of Experimental Herpes Simplex Keratitis, Invest. Ophthal., to be published. 3. Kaufman, H. E.: Clinical Cure of Herpes Simplex Keratitis by 5-Iodo-2'-Deoxyuridine, Proc. Soc. Exp. Biol. Med., to be published. 4. Kaufman, H. E., and Maloney, E. D.: Experimental Herpes Simplex Keratitis: Effect of Corticosteroids and Epithelial Curettage , Arch. Ophthal. 66:99, 1961.Crossref 5. Tamm, I.: Symposium on the Experimental Pharmacology and Clinical Use of Antimetabolites: III. Metabolic Antagonists and Selective Virus Inhibition , Clin. Pharmacol. Therap. 1:777, 1960. 6. Herrmann, E. C., Jr.: Plaque Inhibition Test for Detection of Specific Inhibitors of DNA Containing Viruses , Proc. Soc. Exp. Biol. Med. 107:142, 1961.Crossref 7. Stocker, M. G. P.: Growth Studies with Herpes Virus , in Virus Growth and Variation: A Symposium , edited by Isaacs, A., and Lacey, B. W., London, Cambridge University Press, 1959. 8. Howard, G. M., and Kaufman, H. E.: Review of Herpes Simplex Keratitis , Arch. Ophthal. 67: 373, 1962.Crossref 9. Gundersen, T.: Herpes Corneae: With Special References to Its Treatment with Strong Solution of Iodine , Arch. Ophthal. 15:225, 1936.Crossref 10. Welch, A. D., and Prusoff, W. H.: Synopsis of Recent Investigations of 5-Iodo-2'-Deoxyuridine, Cancer Chemother. (Rep. 6) p. 29, 1960. 11. Goodman, L., and Gilman, A.: Pharmacological Basis of Therapeutics , New York, The Macmillan Company, 1955, pp. 1276-1317. 12. Goodman, L., and Gilman, A.,10 pp. 1394-1399. 13. Goodman, L., and Gilman, A.,10 pp. 1324-1357. 14. Goodman, L., and Gilman, A.,10 pp. 1182-1183. 15. Kaufman, H. E.; Martola, E-L., and Dohlman, C-H.: The Use of a New Viral Antibiotic in the Treatment of Herpes Simplex Keratitis, in preparation.

Journal

Archives of Ophthalmology – American Medical Association

Published: May 1, 1962

References

  • Experimental Herpes Simplex Keratitis: Effect of Corticosteroids and Epithelial Curettage
    Kaufman , H. E., and Maloney, E. D.
  • Symposium on the Experimental Pharmacology and Clinical Use of Antimetabolites: III. Metabolic Antagonists and Selective Virus Inhibition
    Tamm , I.
  • Plaque Inhibition Test for Detection of Specific Inhibitors of DNA Containing Viruses
    Herrmann , E. C., Jr.
  • Virus Growth and Variation: A Symposium
    Stocker , M. G. P.
  • Review of Herpes Simplex Keratitis
    Howard , G. M., and Kaufman, H. E.
  • Herpes Corneae: With Special References to Its Treatment with Strong Solution of Iodine
    Gundersen , T.
  • Pharmacological Basis of Therapeutics
    Goodman , L., and Gilman, A.