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IDU and Hydrocortisone in Experimental Herpes Simplex Keratitis

IDU and Hydrocortisone in Experimental Herpes Simplex Keratitis Abstract The indiscriminate clinical use of corticosteroids "when the eye is red" has contributed greatly to the severity and variety of herpes simplex keratitis.1,2 Similarly, the deleterious effects of corticosteroids on experimental herpes simplex keratitis have been well documented.3,4 Since, when used indiscriminately, corticosteroids are dangerous, and since the antiviral agents described to date are not effective in treating iritis or disease accompanied by folds in Descemet's membrane,5 it would be desirable if topical corticosteroids could be used with safety. The preparation, 5-iodo-2'-deoxyuridine (IDU), is a specific antiviral agent that stops viral replication.6,7 The experiments described below document the effects of the combination of IDU with corticosteroids. Methods and Materials Albino rabbits were infected with strains of herpes simplex virus as previously described.6 Drops of IDU were administered as a 0.1% solution and hydrocortisone as a 0.5% solution. In some experiments, when the two were given References 1. Howard, G. M., and Kaufman, H. E.: Herpes Simplex Keratitis, Review , Arch. Ophthal. 67:373, 1962.Crossref 2. Thygeson, P.; Hogan, M. J., and Kimura, S. J.: Cortisone and Hydrocortisone in Ocular Infections , Trans. Amer. Acad. Ophthal. Otolaryng. 57: 64, 1953. 3. Kimura, S. J., and Okumoto, M.: The Effect of Corticosteroids on Experimental Herpes Simplex Keratoconjunctivitis in the Rabbit , Amer. J. Ophthal. 43:131 (April, (Pt. 2) ) 1957. 4. Kaufman, H. E., and Maloney, E. D.: Experimental Herpes Simplex Keratitis: The Effect of Corticosteroids and Epithelial Curettage , Arch. Ophthal. 66:99, 1961.Crossref 5. Kaufman, H. E.; Martola, E-L., and Dohlman, C. H.: The Use of 5-Iodo-2'-Deoxyuridine (IDU) in the Treatment of Herpes Simplex Keratitis , Arch. Ophthal. 67:235, 1962.Crossref 6. Kaufman, H. E.; Nesburn, A. B., and Maloney, E. D.: IDU Therapy of Herpes Simplex Keratitis , Arch. Ophthal. , 67:583, 1962.Crossref 7. Kaufman, H. E.: Clinical Cure of Herpes Simplex Keratitis by 5-Iodo-2'-Deoxyuridine (IDU) , Proc. Soc. Exp. Biol. Med. 109:251, 1962.Crossref 8. Kaufman, H. E.; Remington, J. S.; Melton, M. L., and Jacobs, L.: Relative Resistance of Slow-Growing Strains of Toxoplasma Gondii to Pyrimethamine (Daraprim) , A.M.A. Arch. Ophthal. 62: 611, 1959.Crossref 9. Kaufman, H. E.; Martola, E-L. and Dohlman, C. H.: Herpes Simplex Treatment with IDU and Corticosteroids: A Clinical Study, in preparation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

IDU and Hydrocortisone in Experimental Herpes Simplex Keratitis

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960030400014
Publisher site
See Article on Publisher Site

Abstract

Abstract The indiscriminate clinical use of corticosteroids "when the eye is red" has contributed greatly to the severity and variety of herpes simplex keratitis.1,2 Similarly, the deleterious effects of corticosteroids on experimental herpes simplex keratitis have been well documented.3,4 Since, when used indiscriminately, corticosteroids are dangerous, and since the antiviral agents described to date are not effective in treating iritis or disease accompanied by folds in Descemet's membrane,5 it would be desirable if topical corticosteroids could be used with safety. The preparation, 5-iodo-2'-deoxyuridine (IDU), is a specific antiviral agent that stops viral replication.6,7 The experiments described below document the effects of the combination of IDU with corticosteroids. Methods and Materials Albino rabbits were infected with strains of herpes simplex virus as previously described.6 Drops of IDU were administered as a 0.1% solution and hydrocortisone as a 0.5% solution. In some experiments, when the two were given References 1. Howard, G. M., and Kaufman, H. E.: Herpes Simplex Keratitis, Review , Arch. Ophthal. 67:373, 1962.Crossref 2. Thygeson, P.; Hogan, M. J., and Kimura, S. J.: Cortisone and Hydrocortisone in Ocular Infections , Trans. Amer. Acad. Ophthal. Otolaryng. 57: 64, 1953. 3. Kimura, S. J., and Okumoto, M.: The Effect of Corticosteroids on Experimental Herpes Simplex Keratoconjunctivitis in the Rabbit , Amer. J. Ophthal. 43:131 (April, (Pt. 2) ) 1957. 4. Kaufman, H. E., and Maloney, E. D.: Experimental Herpes Simplex Keratitis: The Effect of Corticosteroids and Epithelial Curettage , Arch. Ophthal. 66:99, 1961.Crossref 5. Kaufman, H. E.; Martola, E-L., and Dohlman, C. H.: The Use of 5-Iodo-2'-Deoxyuridine (IDU) in the Treatment of Herpes Simplex Keratitis , Arch. Ophthal. 67:235, 1962.Crossref 6. Kaufman, H. E.; Nesburn, A. B., and Maloney, E. D.: IDU Therapy of Herpes Simplex Keratitis , Arch. Ophthal. , 67:583, 1962.Crossref 7. Kaufman, H. E.: Clinical Cure of Herpes Simplex Keratitis by 5-Iodo-2'-Deoxyuridine (IDU) , Proc. Soc. Exp. Biol. Med. 109:251, 1962.Crossref 8. Kaufman, H. E.; Remington, J. S.; Melton, M. L., and Jacobs, L.: Relative Resistance of Slow-Growing Strains of Toxoplasma Gondii to Pyrimethamine (Daraprim) , A.M.A. Arch. Ophthal. 62: 611, 1959.Crossref 9. Kaufman, H. E.; Martola, E-L. and Dohlman, C. H.: Herpes Simplex Treatment with IDU and Corticosteroids: A Clinical Study, in preparation.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1962

References