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Idiopathic Lethal Granulomas of the Midline Facial Tissues

Idiopathic Lethal Granulomas of the Midline Facial Tissues Abstract Introduction Cases of idiopathic lethal granulomas of the midline facial tissues are being reported frequently in the general medical literature. However, since such patients often consult a dermatologist because of an ulceration or tumor of the palate, it is the purpose of this report to reemphasize this disease in the dermatological literature. The most recent review was by Levan,1 in 1953, and a related condition was reported by Lincoln,2 in 1957. Recent investigation regarding the etiology as well as the treatment will be discussed. Report of a Case A 48-year-old white woman was first seen by the dermatology service at the Mary Hitchcock Memorial Hospital in September, 1956, at which time she had returned to the hospital for reevaluation of sprue, previously diagnosed in April, 1956. In addition, she complained now of a sore throat of several weeks' duration, References 1. Levan, N. E.: Malignant Granuloam of the Face , A. M. A. Arch. Dermat. & Syph. 68:187-200, 1953. 2. Lincoln, C. S., Jr.: Disseminated Pathergic (Allergic) Granulomatosis: The Histopathologic Picture of a Cutaneous Lesion; Report of a Case , A. M. A. Arch. Dermat. 75:107-111, 1957. 3. McBride, P.: Case of Rapid Destruction of the Nose and Face , Proceedings of the Laryngological Society of London, 1896 . 4. Stewart, J. P.: Progressive Lethal Granulomatous Ulceration of the Nose , J. Laryng. & Otol. 48:657-701, 1933. 5. Williams, H. L.: Lethal Granulomatous Ulceration Involving the Midline Facial Tissues , Ann. Otol. Rhin. & Laryng. 58:1013-1054, 1949. 6. Kahn, R. L.: Tissue Immunity , Springfield, Charles C Thomas, Publisher, 1936. 7. Weinberg, T.: Periarteritis Nodosa in Granuloma of Unknown Etiology: Report of 2 Cases , Am. J. Clin. Path. 16:784-791, 1946. 8. Rich, A. R.: Role of Hypersensitivity in Periarteritis Nodosa (as Indicated by 7 Cases Developing During Serum Sickness and Sulfonamide Therapy) , Bull. Johns Hopkins Hosp. 71:123-140, 1942. 9. Rich, A. R., and Gregory, J. E.: Experimental Demonstration That Periarteritis Nodosa Is a Manifestation of Hypersensitivity , Bull. Johns Hopkins Hosp. 72:65-82, 1943. 10. Duff, G. L.: Discussion , Am. J. Path. 22:646, 1946. 11. Selye, H.: The General Adaptation Syndrome and Diseases of Adaptation , J. Clin. Endocrinol. 6:117-230, 1946. 12. Moore, P. M.; Beard, E. E., Thoburn, T. W., and Williams, H. L.: Idiopathic (Lethal) Granuloma of the Midline Facial Tissues Treated with Cortisone: Report of a Case , Laryngoscope 61:320-331, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Idiopathic Lethal Granulomas of the Midline Facial Tissues

A.M.A. Archives of Dermatology , Volume 79 (4) – Apr 1, 1959

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560160008002
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Cases of idiopathic lethal granulomas of the midline facial tissues are being reported frequently in the general medical literature. However, since such patients often consult a dermatologist because of an ulceration or tumor of the palate, it is the purpose of this report to reemphasize this disease in the dermatological literature. The most recent review was by Levan,1 in 1953, and a related condition was reported by Lincoln,2 in 1957. Recent investigation regarding the etiology as well as the treatment will be discussed. Report of a Case A 48-year-old white woman was first seen by the dermatology service at the Mary Hitchcock Memorial Hospital in September, 1956, at which time she had returned to the hospital for reevaluation of sprue, previously diagnosed in April, 1956. In addition, she complained now of a sore throat of several weeks' duration, References 1. Levan, N. E.: Malignant Granuloam of the Face , A. M. A. Arch. Dermat. & Syph. 68:187-200, 1953. 2. Lincoln, C. S., Jr.: Disseminated Pathergic (Allergic) Granulomatosis: The Histopathologic Picture of a Cutaneous Lesion; Report of a Case , A. M. A. Arch. Dermat. 75:107-111, 1957. 3. McBride, P.: Case of Rapid Destruction of the Nose and Face , Proceedings of the Laryngological Society of London, 1896 . 4. Stewart, J. P.: Progressive Lethal Granulomatous Ulceration of the Nose , J. Laryng. & Otol. 48:657-701, 1933. 5. Williams, H. L.: Lethal Granulomatous Ulceration Involving the Midline Facial Tissues , Ann. Otol. Rhin. & Laryng. 58:1013-1054, 1949. 6. Kahn, R. L.: Tissue Immunity , Springfield, Charles C Thomas, Publisher, 1936. 7. Weinberg, T.: Periarteritis Nodosa in Granuloma of Unknown Etiology: Report of 2 Cases , Am. J. Clin. Path. 16:784-791, 1946. 8. Rich, A. R.: Role of Hypersensitivity in Periarteritis Nodosa (as Indicated by 7 Cases Developing During Serum Sickness and Sulfonamide Therapy) , Bull. Johns Hopkins Hosp. 71:123-140, 1942. 9. Rich, A. R., and Gregory, J. E.: Experimental Demonstration That Periarteritis Nodosa Is a Manifestation of Hypersensitivity , Bull. Johns Hopkins Hosp. 72:65-82, 1943. 10. Duff, G. L.: Discussion , Am. J. Path. 22:646, 1946. 11. Selye, H.: The General Adaptation Syndrome and Diseases of Adaptation , J. Clin. Endocrinol. 6:117-230, 1946. 12. Moore, P. M.; Beard, E. E., Thoburn, T. W., and Williams, H. L.: Idiopathic (Lethal) Granuloma of the Midline Facial Tissues Treated with Cortisone: Report of a Case , Laryngoscope 61:320-331, 1951.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1959

References