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Idiopathic Lenticular Mucocutaneous Pigmentation or Laugier-Hunziker Syndrome With Atypical Features

Idiopathic Lenticular Mucocutaneous Pigmentation or Laugier-Hunziker Syndrome With Atypical Features Abstract Laugier-Hunziker syndrome is a rare, acquired pigmentary disorder of the lips, oral mucosa, and nails. In 1970, Laugier and Hunziker1 reported on 5 cases of essential melanotic pigmentation of the mouth and lips. Two of these patients also displayed pigmentary changes of the nails. In the meantime, several authors,2 particularly from western Europe, presented more patients with this syndrome. Recently, we examined a patient with mucocutaneous features of both Laugier-Hunziker and Peutz-Jeghers syndrome, whose family history was negative, and in whom, on repeated examinations, intestinal polyposis was not detectable. Report of a Case. A 50-year-old white man first presented at our outpatient clinic in 1982 with a 12-year history of asymptomatic melanotic macules on his lips, oral mucosa, and several fingers. Apart from a noninsulin-dependent diabetes mellitus and coronary heart disease, which had been treated with glibenclamid and sotalol since 1981, his personal history was unremarkable. There was References 1. Laugier P, Hunziker N. Pigmentation méelanique lenticulaire essentielle de la muqueuse jugale et des lèvres . Arch Belg Dermatol Syphilol. 1970;26:391-399. 2. Veraldi S, Cavicchini S, Benelli C, Gasparini G. Laugier-Hunziker syndrome: a clinical, histopathologic, and ultrastructural study of four cases and review of the literature . J Am Acad Dermatol. 1991;25:632-636.Crossref 3. Fry L, Almeyda JR. The incidence of buccal pigmentation in caucasoids and negroids in Britain . Br J Dermatol. 1968;80:244-247.Crossref 4. Valero A, Sherf K. Pigmented nails in Peutz-Jeghers syndrome . Am J Gastroenterol. 1965;43:56-58. 5. Burdick D, Prior JT. Peutz-Jeghers syndrome: a clinicopathologic study of a large family with a 27-year follow-up . Cancer . 1982;50:2139-2146.Crossref 6. Bologa El, Bene M, Pasztor P. Considérations sur la lentiginose éruptive de la face . Ann Dermatol Syphiligr. 1965;92:277-286. 7. Calnan CD. The Peutz-Jeghers syndrome . Trans St John's Hosp Dermatol Soc. 1960;44:58-64. 8. Dal Tio R, Di Vito F, Grasso F. Iperpigmentazione a tipo 'sindrome di Laugier-Hunziker' insorta in corso di polichemioterapia antineoplastica . G Ital Dermatol Venereol. 1989;124:77-83. 9. Rhodes AR. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes . In: Fitzpatrick TB, Eisen AZ, Wolff K, et al, eds. Dermatology in General Medicine . New York, NY: McGraw-Hill International Book Co; 1993:1049-1050. 10. Dupré A, Viraben R. Laugier's disease . Dermatologica . 1990;181:183-186.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Idiopathic Lenticular Mucocutaneous Pigmentation or Laugier-Hunziker Syndrome With Atypical Features

Archives of Dermatology , Volume 132 (7) – Jul 1, 1996

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890310136032
Publisher site
See Article on Publisher Site

Abstract

Abstract Laugier-Hunziker syndrome is a rare, acquired pigmentary disorder of the lips, oral mucosa, and nails. In 1970, Laugier and Hunziker1 reported on 5 cases of essential melanotic pigmentation of the mouth and lips. Two of these patients also displayed pigmentary changes of the nails. In the meantime, several authors,2 particularly from western Europe, presented more patients with this syndrome. Recently, we examined a patient with mucocutaneous features of both Laugier-Hunziker and Peutz-Jeghers syndrome, whose family history was negative, and in whom, on repeated examinations, intestinal polyposis was not detectable. Report of a Case. A 50-year-old white man first presented at our outpatient clinic in 1982 with a 12-year history of asymptomatic melanotic macules on his lips, oral mucosa, and several fingers. Apart from a noninsulin-dependent diabetes mellitus and coronary heart disease, which had been treated with glibenclamid and sotalol since 1981, his personal history was unremarkable. There was References 1. Laugier P, Hunziker N. Pigmentation méelanique lenticulaire essentielle de la muqueuse jugale et des lèvres . Arch Belg Dermatol Syphilol. 1970;26:391-399. 2. Veraldi S, Cavicchini S, Benelli C, Gasparini G. Laugier-Hunziker syndrome: a clinical, histopathologic, and ultrastructural study of four cases and review of the literature . J Am Acad Dermatol. 1991;25:632-636.Crossref 3. Fry L, Almeyda JR. The incidence of buccal pigmentation in caucasoids and negroids in Britain . Br J Dermatol. 1968;80:244-247.Crossref 4. Valero A, Sherf K. Pigmented nails in Peutz-Jeghers syndrome . Am J Gastroenterol. 1965;43:56-58. 5. Burdick D, Prior JT. Peutz-Jeghers syndrome: a clinicopathologic study of a large family with a 27-year follow-up . Cancer . 1982;50:2139-2146.Crossref 6. Bologa El, Bene M, Pasztor P. Considérations sur la lentiginose éruptive de la face . Ann Dermatol Syphiligr. 1965;92:277-286. 7. Calnan CD. The Peutz-Jeghers syndrome . Trans St John's Hosp Dermatol Soc. 1960;44:58-64. 8. Dal Tio R, Di Vito F, Grasso F. Iperpigmentazione a tipo 'sindrome di Laugier-Hunziker' insorta in corso di polichemioterapia antineoplastica . G Ital Dermatol Venereol. 1989;124:77-83. 9. Rhodes AR. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes . In: Fitzpatrick TB, Eisen AZ, Wolff K, et al, eds. Dermatology in General Medicine . New York, NY: McGraw-Hill International Book Co; 1993:1049-1050. 10. Dupré A, Viraben R. Laugier's disease . Dermatologica . 1990;181:183-186.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1996

References