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Idiopathic Anaphylaxis: An Attempt to Estimate the Incidence in the United States

Idiopathic Anaphylaxis: An Attempt to Estimate the Incidence in the United States Abstract Background: Idiopathic anaphylaxis has been described and classified, and increasing numbers of cases are being seen in the United States and abroad. Treatment regimens have been shown to be effective in prophylactic management. There is no available information about the number of cases in the United States. Method: We attempted to determine the number of cases of idiopathic anaphylaxis in the United States by mailing a questionnaire to all graduates (for the last 31 years) of the Northwestern University Allergy-Immunology Fellowship training program. Results: Response to the questionnaire was 100%, and 633 cases were reported by this survey of 75 allergists. The current total number of identified cases of idiopathic anaphylaxis from all reports of cases in the United States is 1020. Conclusions: By extrapolation of the cases of idiopathic anaphylaxis reported by the allergists surveyed to the approximately 4000 allergists in the United States, the estimated number of cases in the United States is between 20592 and 47024. Idiopathic anaphylaxis is potentially fatal, represents a source of major medical health care costs, causes anxiety to patients and families, occurs in pediatric and adult populations, and is controlled by appropriate regimens. The estimated number of cases emphasizes the need for careful attention to idiopathic anaphylaxis by physicians.(Arch Intern Med. 1995;155:869-871) References 1. Bacal E, Patterson R, Zelss CR. Evaluation of severe (anaphylactlc) reactions. Clin Allergy . 1978;8:295-304.Crossref 2. Lieberman P, Taylor WW Jr. Recurrent idiopathic anaphylaxis. Arch Intern Med . 1979;139:1032-1034.Crossref 3. Sale SR, Greenberger PA, Patterson R. Idiopathic anaphylactoid reactions. JAMA . 1981;246:2336-2339.Crossref 4. Boxer M, Greenberger PA, Patterson R. Clinical summary and course of idiopathic anaphylaxis in 73 patients. Arch Intern Med . 1987;147:269-272.Crossref 5. Wiggins CA, Dykewicz MS, Patterson R. Idiopathic anaphylaxis: classification, evaluation, and treatment of 123 patients. J Allergy Clin Immunol . 1988;82: 849-855.Crossref 6. Orfan NA, Stoloff RS, Harris KE, Patterson R. Idiopathic anaphylaxis: total experience with 225 patients. Allergy Proc . 1992;13:35-43.Crossref 7. Boxer MB, Greenberger PA, Patterson R. The impact of prednisone in life-threatening idiopathic anaphylaxis: reduction in acute episodes and medical costs. Ann Allergy . 1989;62:201-204. 8. Patterson R, Stoloff RS, Greenberger PA, Grammer LC, Harris KE. Algorithms for the diagnosis and management of idiopathic anaphylaxis. Ann Allergy . 1993; 71:40-44. 9. Tejedor MA, Perez C, de la Hoz B, Puras A, Pascual M, Martin-Esteban M. Idiopathic anaphylaxis (IA): a heterogeneous population. J Allergy Clin Immunol . 1994:93:302. 10. Khan DA, Yocum W. Idiopathic anaphylaxis (IA): prognosis. Ann Allergy . 1984; 72:73. 11. Patterson R, Booth BH, Clayton DE, Greenberger PA, Harris KE. Fatal and near fatal anaphylaxis. Allergy Proc . In press. 12. Glantz SA. Confidence intervals. In: Primer of Biostatistics . 2nd ed. New York, NY: McGraw-Hill International Book Co; 1987:163-190. 13. Wong S, Yarnold PR, Yango C, et al. Outcome of prophylactic therapy for idiopathic anaphylaxis. Ann Intern Med . 1991;114:133-136.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Idiopathic Anaphylaxis: An Attempt to Estimate the Incidence in the United States

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1995.00430080119014
Publisher site
See Article on Publisher Site

Abstract

Abstract Background: Idiopathic anaphylaxis has been described and classified, and increasing numbers of cases are being seen in the United States and abroad. Treatment regimens have been shown to be effective in prophylactic management. There is no available information about the number of cases in the United States. Method: We attempted to determine the number of cases of idiopathic anaphylaxis in the United States by mailing a questionnaire to all graduates (for the last 31 years) of the Northwestern University Allergy-Immunology Fellowship training program. Results: Response to the questionnaire was 100%, and 633 cases were reported by this survey of 75 allergists. The current total number of identified cases of idiopathic anaphylaxis from all reports of cases in the United States is 1020. Conclusions: By extrapolation of the cases of idiopathic anaphylaxis reported by the allergists surveyed to the approximately 4000 allergists in the United States, the estimated number of cases in the United States is between 20592 and 47024. Idiopathic anaphylaxis is potentially fatal, represents a source of major medical health care costs, causes anxiety to patients and families, occurs in pediatric and adult populations, and is controlled by appropriate regimens. The estimated number of cases emphasizes the need for careful attention to idiopathic anaphylaxis by physicians.(Arch Intern Med. 1995;155:869-871) References 1. Bacal E, Patterson R, Zelss CR. Evaluation of severe (anaphylactlc) reactions. Clin Allergy . 1978;8:295-304.Crossref 2. Lieberman P, Taylor WW Jr. Recurrent idiopathic anaphylaxis. Arch Intern Med . 1979;139:1032-1034.Crossref 3. Sale SR, Greenberger PA, Patterson R. Idiopathic anaphylactoid reactions. JAMA . 1981;246:2336-2339.Crossref 4. Boxer M, Greenberger PA, Patterson R. Clinical summary and course of idiopathic anaphylaxis in 73 patients. Arch Intern Med . 1987;147:269-272.Crossref 5. Wiggins CA, Dykewicz MS, Patterson R. Idiopathic anaphylaxis: classification, evaluation, and treatment of 123 patients. J Allergy Clin Immunol . 1988;82: 849-855.Crossref 6. Orfan NA, Stoloff RS, Harris KE, Patterson R. Idiopathic anaphylaxis: total experience with 225 patients. Allergy Proc . 1992;13:35-43.Crossref 7. Boxer MB, Greenberger PA, Patterson R. The impact of prednisone in life-threatening idiopathic anaphylaxis: reduction in acute episodes and medical costs. Ann Allergy . 1989;62:201-204. 8. Patterson R, Stoloff RS, Greenberger PA, Grammer LC, Harris KE. Algorithms for the diagnosis and management of idiopathic anaphylaxis. Ann Allergy . 1993; 71:40-44. 9. Tejedor MA, Perez C, de la Hoz B, Puras A, Pascual M, Martin-Esteban M. Idiopathic anaphylaxis (IA): a heterogeneous population. J Allergy Clin Immunol . 1994:93:302. 10. Khan DA, Yocum W. Idiopathic anaphylaxis (IA): prognosis. Ann Allergy . 1984; 72:73. 11. Patterson R, Booth BH, Clayton DE, Greenberger PA, Harris KE. Fatal and near fatal anaphylaxis. Allergy Proc . In press. 12. Glantz SA. Confidence intervals. In: Primer of Biostatistics . 2nd ed. New York, NY: McGraw-Hill International Book Co; 1987:163-190. 13. Wong S, Yarnold PR, Yango C, et al. Outcome of prophylactic therapy for idiopathic anaphylaxis. Ann Intern Med . 1991;114:133-136.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 24, 1995

References