Abstract From 1955 to 1965, 117 patients with idiopathic acquired hemolytic anemia were observed. Survival was 91% at one year, 76% at five years, and 73% at ten years. The data suggest that survival has no significant relationship to the age of the patient at the time of diagnosis, to sex, or to hemoglobin level, leukocyte count, platelet count, reticulocyte count, or presence or absence of splenomegaly or a positive Coombs' test at the time of the initial examination. Survival data suggested (but did not confirm) that, at the five- and ten-year periods of observation, patients treated with both splenectomy and corticosteroids have a more favorable prognosis than do patients treated with corticosteroids alone. References 1. Elveback L: Estimation of survivorship in chronic diseases: The "actuarial" method. J Amer Statist Assoc 53:420-440, 1958. 2. Allgood JW, Chaplin H Jr: Idiopathic acquired autoimmune hemolytic anemia: A review of 47 cases treated from 1955 through 1965. Amer J Med 43:254-273, 1967.Crossref 3. Dausset J, Colombani J: The serology and prognosis of 128 cases of autoimmune hemolytic anemia. Blood 14:1280-1301, 1959. 4. Crosby WH, Rappaport H: Autoimmune hemolytic anemia: I. Analysis of hematologic observations with particular reference to their prognostic value: A survey of 57 cases. Blood 12:42-55, 1957. 5. Dacie JV: The auto-immune haemolytic anaemias , in The Haemolytic Anaemias: Congenital and Acquired , ed 2. New York, Grune & Stratton Inc, 1962. 6. Dacie JV, Worlledge SM: Auto-immune hemolytic anemias. Progr Hemat 6:82-120, 1969. 7. Doan CA, Bruce MD, Wiseman K: Hypersplenic cytopenic syndromes: A 25 year experience with special reference to splenectomy , in Proceedings of the Sixth International Congress of the International Society of Hematology. New York, Grune & Stratton Inc, 1958, pp 429-442.
Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1972