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I I-CIS VITAMIN A IN THE TREATMENT OF RETINITIS PIGMENTOSA

I I-CIS VITAMIN A IN THE TREATMENT OF RETINITIS PIGMENTOSA Abstract To the Editor: —From 1956 to 1958, animal studies were performed using newborn white rats1 which demonstrated that subminimal doses of 11-cis vitamin A will protect the retina of a newborn rat and prevent retinal rod degeneration but would not prevent somatic changes of vitamin A deficiency. This indicated that in the newborn white rat, 11-cis vitamin A was necessary for the metabolism and viability of the retinal rods.The vitamin A in our normal diets and in vitamin capsules is in the all-trans form and must be isomerized somewhere in the body to produce 11-cis vitamin A to be utilized by the retinal rods. In retinitis pigmentosa there is progressive degeneration of the retinal rods. It is postulated that individuals with this disease have an hereditary or constitutional inability to make the normal isomerization from all-trans to 11-cis vitamin A, thereby resulting in gradual retinal rod degeneration. The References 1. Chatzinoff, A.; Millman, N.; Oroshnik, W., and Rosen, F.: 11-Cis Vitamin A in the Prevention of Retinal Rod Degeneration , Amer. J. Ophthal. 46:205, 1958. 2. Hubbard, R.: Retinene Isomerase , J. Gen. Physiol. 39:935, 1956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

I I-CIS VITAMIN A IN THE TREATMENT OF RETINITIS PIGMENTOSA

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960030153029
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor: —From 1956 to 1958, animal studies were performed using newborn white rats1 which demonstrated that subminimal doses of 11-cis vitamin A will protect the retina of a newborn rat and prevent retinal rod degeneration but would not prevent somatic changes of vitamin A deficiency. This indicated that in the newborn white rat, 11-cis vitamin A was necessary for the metabolism and viability of the retinal rods.The vitamin A in our normal diets and in vitamin capsules is in the all-trans form and must be isomerized somewhere in the body to produce 11-cis vitamin A to be utilized by the retinal rods. In retinitis pigmentosa there is progressive degeneration of the retinal rods. It is postulated that individuals with this disease have an hereditary or constitutional inability to make the normal isomerization from all-trans to 11-cis vitamin A, thereby resulting in gradual retinal rod degeneration. The References 1. Chatzinoff, A.; Millman, N.; Oroshnik, W., and Rosen, F.: 11-Cis Vitamin A in the Prevention of Retinal Rod Degeneration , Amer. J. Ophthal. 46:205, 1958. 2. Hubbard, R.: Retinene Isomerase , J. Gen. Physiol. 39:935, 1956.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1962

References