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Hypothermia in Acute Hemorrhagic Pancreatitis: Experimental Study and Clinical Trial

Hypothermia in Acute Hemorrhagic Pancreatitis: Experimental Study and Clinical Trial Abstract The mortality in acute hemorrhagic pancreatitis remains high despite all therapeutic measures and much experimental work. Theoretically it would seem that any measure tending to suppress the activity of the pancreas would aid in the management of this disease. Wangensteen and his co-workers1 used intragastric cooling to control massive upper gastrointestinal tract bleeding and noted that the gastric secretory activity was depressed. More recently, Nabseth2 reported questionable benefits from the use of intragastric cooling in the management of acute hemorrhagic pancreatitis. It occurred to us that pancreatic activity might perhaps be effectively reduced by the induction of total body hypothermia. Accordingly, a laboratory experiment was undertaken. Although experimental pancreatitis in dogs may not be identical with the disease in man, the physiologic defects produced are identical, and treatment which helps one usually helps the other. Experimental Study Method Acute hemorrhagic pancreatitis was surgically induced in 40 mongrel dogs References 1. Wangensteen, O. H.; Root, H. D.; Jenson, C. B.; Imamoglu, K., and Salmon, P. A.: Depression of Gastric Secretion and Digestion by Gastric Hypothermia: Its Clinical Use in Massive Hematemesis , Surgery 44:265, 1958. 2. Nabseth, D. C.; Goodal, R. L., and Reif, A. E.: Studies on the Effect of Intragastric Cooling on Acute Experimental Pancreatitis , Surgery 47:542-547, 1960. 3. Kenwell, H. N., and Wels, P. B.: Acute Hemorrhagic Pancreatitis , Surg. Gynec. Obstet. 96:169-170, 1953. 4. West, E. S., and Todd, W. R.: Textbook of Biochemistry , Ed. 2, New York, The Macmillan Company, 1955. 5. Enquist, I. F.; Rosen, R.; Aiello, R. G., and Ikezono, E., Arch. Surg. 82:281-284 ( (Feb.) ) 1961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Hypothermia in Acute Hemorrhagic Pancreatitis: Experimental Study and Clinical Trial

Archives of Surgery , Volume 85 (5) – Nov 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1962.01310050119019
Publisher site
See Article on Publisher Site

Abstract

Abstract The mortality in acute hemorrhagic pancreatitis remains high despite all therapeutic measures and much experimental work. Theoretically it would seem that any measure tending to suppress the activity of the pancreas would aid in the management of this disease. Wangensteen and his co-workers1 used intragastric cooling to control massive upper gastrointestinal tract bleeding and noted that the gastric secretory activity was depressed. More recently, Nabseth2 reported questionable benefits from the use of intragastric cooling in the management of acute hemorrhagic pancreatitis. It occurred to us that pancreatic activity might perhaps be effectively reduced by the induction of total body hypothermia. Accordingly, a laboratory experiment was undertaken. Although experimental pancreatitis in dogs may not be identical with the disease in man, the physiologic defects produced are identical, and treatment which helps one usually helps the other. Experimental Study Method Acute hemorrhagic pancreatitis was surgically induced in 40 mongrel dogs References 1. Wangensteen, O. H.; Root, H. D.; Jenson, C. B.; Imamoglu, K., and Salmon, P. A.: Depression of Gastric Secretion and Digestion by Gastric Hypothermia: Its Clinical Use in Massive Hematemesis , Surgery 44:265, 1958. 2. Nabseth, D. C.; Goodal, R. L., and Reif, A. E.: Studies on the Effect of Intragastric Cooling on Acute Experimental Pancreatitis , Surgery 47:542-547, 1960. 3. Kenwell, H. N., and Wels, P. B.: Acute Hemorrhagic Pancreatitis , Surg. Gynec. Obstet. 96:169-170, 1953. 4. West, E. S., and Todd, W. R.: Textbook of Biochemistry , Ed. 2, New York, The Macmillan Company, 1955. 5. Enquist, I. F.; Rosen, R.; Aiello, R. G., and Ikezono, E., Arch. Surg. 82:281-284 ( (Feb.) ) 1961.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Nov 1, 1962

References