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Hypomelanosis of Ito: Wood's Light and Magnetic Resonance Imaging as Diagnostic Measures

Hypomelanosis of Ito: Wood's Light and Magnetic Resonance Imaging as Diagnostic Measures Abstract • Hypomelanosis of Ito is an uncommonly reported neurocutaneous syndrome with a peculiar pattern of swirling hypopigmentation. The skin markings in the lightly pigmented individual are not easily visualized in regular light but can be readily seen with the use of Wood's light. We describe a 7-month-old female infant with this disorder who presented with intractable convulsions. Computed tomography showed enlargement of the left cerebral hemisphere but was otherwise not definitive. Abnormalities of neuronal migration were demonstrated with magnetic resonance imaging that could not be shown by computed tomography. References 1. Rosemberg S, Arita FN, Campos C, et al: Hypomelanosis of Ito: Case report with involvement of the central nervous system and review of the literature . Neuropediatrics 1984;15:52-55.Crossref 2. Ito M: Studies of melanin: XI. Incontinentia pigmenti achromians, a singular case of nevus depigmentosus systematicus bilateralis . Tohoku J Exp Med 1952;55( (suppl) ):57-59.Crossref 3. Jelinek JE, Bart RS, Schiff SM: Hypomelanosis of Ito ('incontinentia pigmenti achromians') . Arch Dermatol 1973;107:596-601.Crossref 4. Buzas JW, Sina B, Burnet JW: Hypomelanosis of Ito: Report of a case and review of the literature . J Am Acad Dermatol 1981;4:195-204.Crossref 5. David TJ: Hypomelanosis of Ito: A neurocutaneous syndrome . Arch Dis Child 1981;56:798-800.Crossref 6. Schwartz MF, Esterly NB, Fretzin DF, et al: Hypomelanosis of Ito (incontinentia pigmenti achromians): A neurocutaneous syndrome . J Pediatr 1977;90:236-240.Crossref 7. Stoebner P, Grosshans EM: Incontinentia pigmenti achromians (Ito): Étude ultrastructurale . Arch Klin Exp Dermatol 1970;239:227-244.Crossref 8. Cram DL, Fukuyama K: Unilateral systematized hypochromic nevus . Arch Dermatol 1974;109:416.Crossref 9. Donat JF, Walsworth DM, Turk LL: Focal cerebral atrophy in incontinentia pigmenti achromians . AJDC 1980;134:709-710. 10. Peña L, Ruiz-Maldonado R, Tamayo L, et al: Incontinentia pigmenti achromians (Ito's hypomelanosis) . Int J Dermatol 1977;16:194-202.Crossref 11. Happle R, Vakilzadeh F: Hamartomatous dental cusps in hypomelanosis of Ito . Clin Genet 1982;21:65-68.Crossref 12. Miller CA, Parker WD Jr: Hypomelanosis of Ito: Association with a chromosomal abnormality . Neurology 1985;35:607-610.Crossref 13. Ross DL, Liwnicz BH, Chun RWM, et al: Hypomelanosis of Ito (incontinentia pigmenti achromians)—a clinicopathologic study: Macrocephaly and gray matter heterotopias . Neurology 1982;32:1013-1016.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Hypomelanosis of Ito: Wood's Light and Magnetic Resonance Imaging as Diagnostic Measures

Archives of Neurology , Volume 43 (8) – Aug 1, 1986

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1986.00520080086032
Publisher site
See Article on Publisher Site

Abstract

Abstract • Hypomelanosis of Ito is an uncommonly reported neurocutaneous syndrome with a peculiar pattern of swirling hypopigmentation. The skin markings in the lightly pigmented individual are not easily visualized in regular light but can be readily seen with the use of Wood's light. We describe a 7-month-old female infant with this disorder who presented with intractable convulsions. Computed tomography showed enlargement of the left cerebral hemisphere but was otherwise not definitive. Abnormalities of neuronal migration were demonstrated with magnetic resonance imaging that could not be shown by computed tomography. References 1. Rosemberg S, Arita FN, Campos C, et al: Hypomelanosis of Ito: Case report with involvement of the central nervous system and review of the literature . Neuropediatrics 1984;15:52-55.Crossref 2. Ito M: Studies of melanin: XI. Incontinentia pigmenti achromians, a singular case of nevus depigmentosus systematicus bilateralis . Tohoku J Exp Med 1952;55( (suppl) ):57-59.Crossref 3. Jelinek JE, Bart RS, Schiff SM: Hypomelanosis of Ito ('incontinentia pigmenti achromians') . Arch Dermatol 1973;107:596-601.Crossref 4. Buzas JW, Sina B, Burnet JW: Hypomelanosis of Ito: Report of a case and review of the literature . J Am Acad Dermatol 1981;4:195-204.Crossref 5. David TJ: Hypomelanosis of Ito: A neurocutaneous syndrome . Arch Dis Child 1981;56:798-800.Crossref 6. Schwartz MF, Esterly NB, Fretzin DF, et al: Hypomelanosis of Ito (incontinentia pigmenti achromians): A neurocutaneous syndrome . J Pediatr 1977;90:236-240.Crossref 7. Stoebner P, Grosshans EM: Incontinentia pigmenti achromians (Ito): Étude ultrastructurale . Arch Klin Exp Dermatol 1970;239:227-244.Crossref 8. Cram DL, Fukuyama K: Unilateral systematized hypochromic nevus . Arch Dermatol 1974;109:416.Crossref 9. Donat JF, Walsworth DM, Turk LL: Focal cerebral atrophy in incontinentia pigmenti achromians . AJDC 1980;134:709-710. 10. Peña L, Ruiz-Maldonado R, Tamayo L, et al: Incontinentia pigmenti achromians (Ito's hypomelanosis) . Int J Dermatol 1977;16:194-202.Crossref 11. Happle R, Vakilzadeh F: Hamartomatous dental cusps in hypomelanosis of Ito . Clin Genet 1982;21:65-68.Crossref 12. Miller CA, Parker WD Jr: Hypomelanosis of Ito: Association with a chromosomal abnormality . Neurology 1985;35:607-610.Crossref 13. Ross DL, Liwnicz BH, Chun RWM, et al: Hypomelanosis of Ito (incontinentia pigmenti achromians)—a clinicopathologic study: Macrocephaly and gray matter heterotopias . Neurology 1982;32:1013-1016.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Aug 1, 1986

References