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Hypertrophy of the Nerve Roots of the Cauda Equina as a Paraneoplastic Manifestation of Lymphoma

Hypertrophy of the Nerve Roots of the Cauda Equina as a Paraneoplastic Manifestation of Lymphoma IMAGES IN NEUROLOGY Hypertrophy of the Nerve Roots of the Cauda Equina as a Paraneoplastic Manifestation of Lymphoma YPERTROPHY OF THE all visualized osseous structures, spond to immune-modulating cauda equina nerve suggestive of a marrow-replacing therapy and is considered to be a re- rootsisanonspecific process. A cauda equina nerve stricted form of chronic inflamma- tory demyelinating polyradiculo- finding and may be root biopsy specimen showed in- 3,4 H neuropathy. Selective hypertrophy seen in hereditary creased segmental demyelination of the cauda equina has been re- andacquireddemyelinatingneuropa- (Figure 2) with macrophages scat- ported as a paraneoplastic manifes- thiesorduetoinfiltrationofthenerve tered throughout the endoneu- tation associated with bronchial car- rootsbymalignancy.Wedescribeapa- rium. A bone marrow aspirate and cinoid tumors. The cauda equina tient with hypertrophy of the cauda biopsy specimen showed extensive hypertrophy is possibly a restricted equinanerverootsasalikelyparaneo- involvement by lymphoplasma- form of chronic inflammatory de- plastic phenomenon. cytic lymphoma. Immunoelectro- myelinating polyradiculoneuropa- A 60-year-old man was seen for a phoresis showed a small mono- thy and should prompt a search for 3-year history of progressive distal clonal IgM. He was prescribed underlying secondary origins. In par- lower limb paresthesias. For 18 intravenous immunoglobulin (IVIG) ticular, an aggressive search for an months before his http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Hypertrophy of the Nerve Roots of the Cauda Equina as a Paraneoplastic Manifestation of Lymphoma

JAMA Neurology , Volume 62 (11) – Nov 1, 2005

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Publisher
American Medical Association
Copyright
Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.62.11.1776
pmid
16286555
Publisher site
See Article on Publisher Site

Abstract

IMAGES IN NEUROLOGY Hypertrophy of the Nerve Roots of the Cauda Equina as a Paraneoplastic Manifestation of Lymphoma YPERTROPHY OF THE all visualized osseous structures, spond to immune-modulating cauda equina nerve suggestive of a marrow-replacing therapy and is considered to be a re- rootsisanonspecific process. A cauda equina nerve stricted form of chronic inflamma- tory demyelinating polyradiculo- finding and may be root biopsy specimen showed in- 3,4 H neuropathy. Selective hypertrophy seen in hereditary creased segmental demyelination of the cauda equina has been re- andacquireddemyelinatingneuropa- (Figure 2) with macrophages scat- ported as a paraneoplastic manifes- thiesorduetoinfiltrationofthenerve tered throughout the endoneu- tation associated with bronchial car- rootsbymalignancy.Wedescribeapa- rium. A bone marrow aspirate and cinoid tumors. The cauda equina tient with hypertrophy of the cauda biopsy specimen showed extensive hypertrophy is possibly a restricted equinanerverootsasalikelyparaneo- involvement by lymphoplasma- form of chronic inflammatory de- plastic phenomenon. cytic lymphoma. Immunoelectro- myelinating polyradiculoneuropa- A 60-year-old man was seen for a phoresis showed a small mono- thy and should prompt a search for 3-year history of progressive distal clonal IgM. He was prescribed underlying secondary origins. In par- lower limb paresthesias. For 18 intravenous immunoglobulin (IVIG) ticular, an aggressive search for an months before his

Journal

JAMA NeurologyAmerican Medical Association

Published: Nov 1, 2005

References