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HYPERTROPHIC LICHEN PLANUS IN WEST AFRICAN NEGROES

HYPERTROPHIC LICHEN PLANUS IN WEST AFRICAN NEGROES Abstract DURING the war of 1939 to 1945, a large number of papers were written on the appearance of a lichen-planus-like disease among white troops in the tropics who had been taking quinacrine. That quinacrine is concerned in the etiology there can be no doubt.1 What is the precise mechanism, however, is open to different interpretations. It is usually assumed to be a toxic or allergic manifestation following treatment with quinacrine, i. e., a drug eruption, but equally quinacrine could act as a trigger factor in activating a lichen-planus-like disease endemic to the tropics, as fever may activate herpes febrilis or arsenic activate herpes zoster. Whatever the explanation, a disease resembling lichen planus hypertrophicus and which I believe in fact to be this disease is relatively common among the Negroes of southern Nigeria. The picture is striking and characteristic and has not, so far as I am aware, been commented References 1. Sulzberger, M. B., and Baer, R. L.: 1944 Year Book of Dermatology and Syphilology , Chicago, The Year Book Publishers, Inc., 1945, p. 30. 2. Clarke, G. H. V.: A Case of Mepacrine Dermatitis , Brit. M. J. 2:58 ( (July 9) ) 1949.Crossref 3. Foerster, H. R., in discussion on Nomland, R.: A Case for Diagnosis (Prurigo Mitis in a Negro?); Dermatosis Papulosa Nigra , Arch. Dermat. & Syph. 22:187 ( (July) ) 1930. 4. Loewenthal, L. J. A.: Diseases of the Skin in Negroes , J. Trop. Med. 39:277 ( (Dec.) ) 1936. 5. Freudenthal, W.: Amyloid in der Haut , Arch. Dermat. u. Syph. 162:40, 1930. 6. Freudenthal, W., and Dowling, G. B.: Lichen Amyloidosis , Proc. Roy. Soc. Med. 32:1029 ( (July) ) 1939. 7. Haxthausen, H.: Studies on Pathogenesis of Morphea, Vitiligo and Acrodermatitis Atrophicans by Means of Transplantation Experiments , Acta dermat.-venereol. 27:352, 1947. 8. Wise, F., and Sulzberger, M. B.: Drug Eruptions: Fixed Phenolphthalein Eruptions , Arch. Dermat. & Syph. 27:549 ( (April) ) 1933. 9. Barber, cited by Sequeira, J. H.; Ingram, J. T., and Brain, R. T.: Diseases of the Skin , ed. 5, London, J. & A. Churchill, Ltd., 1947. 10. Winer, L. H., and Levitt, H.: Lichen Planus in the Negro , Arch. Dermat. & Syph. 56:437 ( (Oct.) ) 1947. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

HYPERTROPHIC LICHEN PLANUS IN WEST AFRICAN NEGROES

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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1951.01570090061008
Publisher site
See Article on Publisher Site

Abstract

Abstract DURING the war of 1939 to 1945, a large number of papers were written on the appearance of a lichen-planus-like disease among white troops in the tropics who had been taking quinacrine. That quinacrine is concerned in the etiology there can be no doubt.1 What is the precise mechanism, however, is open to different interpretations. It is usually assumed to be a toxic or allergic manifestation following treatment with quinacrine, i. e., a drug eruption, but equally quinacrine could act as a trigger factor in activating a lichen-planus-like disease endemic to the tropics, as fever may activate herpes febrilis or arsenic activate herpes zoster. Whatever the explanation, a disease resembling lichen planus hypertrophicus and which I believe in fact to be this disease is relatively common among the Negroes of southern Nigeria. The picture is striking and characteristic and has not, so far as I am aware, been commented References 1. Sulzberger, M. B., and Baer, R. L.: 1944 Year Book of Dermatology and Syphilology , Chicago, The Year Book Publishers, Inc., 1945, p. 30. 2. Clarke, G. H. V.: A Case of Mepacrine Dermatitis , Brit. M. J. 2:58 ( (July 9) ) 1949.Crossref 3. Foerster, H. R., in discussion on Nomland, R.: A Case for Diagnosis (Prurigo Mitis in a Negro?); Dermatosis Papulosa Nigra , Arch. Dermat. & Syph. 22:187 ( (July) ) 1930. 4. Loewenthal, L. J. A.: Diseases of the Skin in Negroes , J. Trop. Med. 39:277 ( (Dec.) ) 1936. 5. Freudenthal, W.: Amyloid in der Haut , Arch. Dermat. u. Syph. 162:40, 1930. 6. Freudenthal, W., and Dowling, G. B.: Lichen Amyloidosis , Proc. Roy. Soc. Med. 32:1029 ( (July) ) 1939. 7. Haxthausen, H.: Studies on Pathogenesis of Morphea, Vitiligo and Acrodermatitis Atrophicans by Means of Transplantation Experiments , Acta dermat.-venereol. 27:352, 1947. 8. Wise, F., and Sulzberger, M. B.: Drug Eruptions: Fixed Phenolphthalein Eruptions , Arch. Dermat. & Syph. 27:549 ( (April) ) 1933. 9. Barber, cited by Sequeira, J. H.; Ingram, J. T., and Brain, R. T.: Diseases of the Skin , ed. 5, London, J. & A. Churchill, Ltd., 1947. 10. Winer, L. H., and Levitt, H.: Lichen Planus in the Negro , Arch. Dermat. & Syph. 56:437 ( (Oct.) ) 1947.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Sep 1, 1951

References