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Hyperthyroidism and Familial Hypertrophic Cardiomyopathy

Hyperthyroidism and Familial Hypertrophic Cardiomyopathy Abstract • A kindred with a high incidence of hypertrophic cardiomyopathy (HC) was studied to identify the presence of clinical hyperthyroidism. Two and possibly three members with HC had associated hyperthyroidism. In the propositus, clinical, ECG, and vectorcardiographic evidence for HC resolved after treatment of the hyperthyroidism. We hypothesize that the disproportionately high correlation of hyperthyroidism and HC and the resolution found in the propositus after treatment may indicate that antithyroid therapy should be considered in this form of cardiomyopathy. (Arch Intern Med 1983;143:378-380) References 1. Clark CE, Henry WL, Epstein SE: Familial prevalence and genetic transmission of idiopathic hypertrophic subaortic stenosis. N Engl J Med 1973;189:709-714.Crossref 2. Symons C, Richardson PJ, Feizi O: Hypertrophic cardiomyopathy and hyperthyroidism: A report of three cases. Thorax 1974;29:713-719.Crossref 3. Bell R, Barber PV, Bray CL, et al: Incidence of thyroid disease in cases of hypertrophic cardiomyopathy. Br Heart J 1978;40:1306-1309.Crossref 4. Wynne J, Braunwald E: The cardiomyopathies and myocarditides in heart disease , in Braunwald E (ed): A Textbook of Cardiovascular Medicine . Philadelphia, WB Saunders Co, 1980 p 1447. 5. Sahn DJ, DeMaria A, Kisslo J, et al: Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements. Circulation 1978;58:1072-1083.Crossref 6. Larter WE, Allen HD, Sahn DJ, et al: The asymmetrically hypertrophied septum: Further differentiation of its causes. Circulation 1976;53: 19-27.Crossref 7. Maron BJ, Epstein SE: Hypertrophic Cardiomyopathy: Recent observations regarding specificity of three hallmarks of the disease: Asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol 1980;45:141-154.Crossref 8. Brock R: Functional obstruction of the left ventricle: Acquired aortic subvalvular stenosis. Guys Hospital Rep 1957;106:221-238. 9. Braunwald E, Lambrew CT, Rockoff SD, et al: Idiopathic Hypertrophic Subaortic Stenosis , monograph No. 10. New York, American Heart Association Inc, 1964, pp 8-11. 10. Sanford CF, Griffin EE, Wildenthal K: Synthesis and degradation of myocardial protein during development and regression of thyroxine-induced cardiac hypertrophy in rats. Circ Res 1978;43:688-694.Crossref 11. Olsen EGJ, Symons C, Hawkey C: Effect of triac on the developing heart. Lancet 1977;2:221-223.Crossref 12. DeGroot LJ: The thyroid , in Beeson PB, McDermott W, Wyngaarden JB (eds): Cecil Textbook of Medicine . Philadelphia, WB Saunders Co, 1979, p 2120. 13. Svejgaard A, Platz P, Ryder LP, et al: HLA and disease association. A survey. Transplant Rev 1975;22:3-43. 14. Darsee JR, Heymsfield SB, Nutter DO: Hypertrophic cardiomyopathy and human leukocyte antigen linkage: Differentiation of two forms of hypertrophic cardiomyopathy. N Engl J Med 1979;300:877-882.Crossref 15. Block A, Crittin J, Barras C, et al: Hypertrophic cardiomyopathy and HLA. N Engl J Med 1980;302:1033.Crossref 16. DeGroot LJ: Thyroid and the heart. Mayo Clinic Proc 1972;47: 864-871. 17. Olsen EGJ, Symons C, Hawkey CM: The effect of triac and propranolol on the developing myocardium in rats, abstracted. Br Heart J 1978;40: 1068.Crossref 18. Bulkley BH, Weisfeld ML, Hutchins GM: Asymmetric septal hypertrophy and myocardial fiber disarray: Features of normal, developing and malformed hearts. Circulation 1977;56:292-298.Crossref 19. Harrower ADB, Fyffe JA, Horn DB, et al: Thyroxine and triiodothyronine levels in hyperthyroid patients during treatment with propranolol. Clin Endocrinol 1977;7:41-49.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Hyperthyroidism and Familial Hypertrophic Cardiomyopathy

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350020208041
Publisher site
See Article on Publisher Site

Abstract

Abstract • A kindred with a high incidence of hypertrophic cardiomyopathy (HC) was studied to identify the presence of clinical hyperthyroidism. Two and possibly three members with HC had associated hyperthyroidism. In the propositus, clinical, ECG, and vectorcardiographic evidence for HC resolved after treatment of the hyperthyroidism. We hypothesize that the disproportionately high correlation of hyperthyroidism and HC and the resolution found in the propositus after treatment may indicate that antithyroid therapy should be considered in this form of cardiomyopathy. (Arch Intern Med 1983;143:378-380) References 1. Clark CE, Henry WL, Epstein SE: Familial prevalence and genetic transmission of idiopathic hypertrophic subaortic stenosis. N Engl J Med 1973;189:709-714.Crossref 2. Symons C, Richardson PJ, Feizi O: Hypertrophic cardiomyopathy and hyperthyroidism: A report of three cases. Thorax 1974;29:713-719.Crossref 3. Bell R, Barber PV, Bray CL, et al: Incidence of thyroid disease in cases of hypertrophic cardiomyopathy. Br Heart J 1978;40:1306-1309.Crossref 4. Wynne J, Braunwald E: The cardiomyopathies and myocarditides in heart disease , in Braunwald E (ed): A Textbook of Cardiovascular Medicine . Philadelphia, WB Saunders Co, 1980 p 1447. 5. Sahn DJ, DeMaria A, Kisslo J, et al: Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements. Circulation 1978;58:1072-1083.Crossref 6. Larter WE, Allen HD, Sahn DJ, et al: The asymmetrically hypertrophied septum: Further differentiation of its causes. Circulation 1976;53: 19-27.Crossref 7. Maron BJ, Epstein SE: Hypertrophic Cardiomyopathy: Recent observations regarding specificity of three hallmarks of the disease: Asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol 1980;45:141-154.Crossref 8. Brock R: Functional obstruction of the left ventricle: Acquired aortic subvalvular stenosis. Guys Hospital Rep 1957;106:221-238. 9. Braunwald E, Lambrew CT, Rockoff SD, et al: Idiopathic Hypertrophic Subaortic Stenosis , monograph No. 10. New York, American Heart Association Inc, 1964, pp 8-11. 10. Sanford CF, Griffin EE, Wildenthal K: Synthesis and degradation of myocardial protein during development and regression of thyroxine-induced cardiac hypertrophy in rats. Circ Res 1978;43:688-694.Crossref 11. Olsen EGJ, Symons C, Hawkey C: Effect of triac on the developing heart. Lancet 1977;2:221-223.Crossref 12. DeGroot LJ: The thyroid , in Beeson PB, McDermott W, Wyngaarden JB (eds): Cecil Textbook of Medicine . Philadelphia, WB Saunders Co, 1979, p 2120. 13. Svejgaard A, Platz P, Ryder LP, et al: HLA and disease association. A survey. Transplant Rev 1975;22:3-43. 14. Darsee JR, Heymsfield SB, Nutter DO: Hypertrophic cardiomyopathy and human leukocyte antigen linkage: Differentiation of two forms of hypertrophic cardiomyopathy. N Engl J Med 1979;300:877-882.Crossref 15. Block A, Crittin J, Barras C, et al: Hypertrophic cardiomyopathy and HLA. N Engl J Med 1980;302:1033.Crossref 16. DeGroot LJ: Thyroid and the heart. Mayo Clinic Proc 1972;47: 864-871. 17. Olsen EGJ, Symons C, Hawkey CM: The effect of triac and propranolol on the developing myocardium in rats, abstracted. Br Heart J 1978;40: 1068.Crossref 18. Bulkley BH, Weisfeld ML, Hutchins GM: Asymmetric septal hypertrophy and myocardial fiber disarray: Features of normal, developing and malformed hearts. Circulation 1977;56:292-298.Crossref 19. Harrower ADB, Fyffe JA, Horn DB, et al: Thyroxine and triiodothyronine levels in hyperthyroid patients during treatment with propranolol. Clin Endocrinol 1977;7:41-49.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1983

References