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HYPERSENSITIVITY OF THE TUBERCULIN TYPE TO CRYSTALLINE PENICILLIN SODIUM

HYPERSENSITIVITY OF THE TUBERCULIN TYPE TO CRYSTALLINE PENICILLIN SODIUM In the limited number of reports that have appeared on the clinical use of penicillin sodium, urticaria seems to be the chief, if not the only, evidence of sensitivity to this drug. Keefer1 reports 14 cases of urticaria out of 500 cases treated and Lyons2 12 cases of urticaria out of 209 treated. These reactions from commercial penicillin sodium, if predicated on a sensitization mechanism, are obviously not necessarily due to penicillin itself. During the course of some studies designed to determine whether a correlation exists between the immediate local reactions obtained with certain lots of commercial penicillin sodium on intramuscular injection in man and those obtained by intracutaneous injection of the same material in rabbits and in man, a person, J. D. W., was injected intracutaneously in the left arm with four lots of commercial penicillin sodium representing the products of three different manufacturers. Each injection consisted http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

HYPERSENSITIVITY OF THE TUBERCULIN TYPE TO CRYSTALLINE PENICILLIN SODIUM

JAMA , Volume 126 (1) – Sep 2, 1944

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1944 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1944.02850360012003
Publisher site
See Article on Publisher Site

Abstract

In the limited number of reports that have appeared on the clinical use of penicillin sodium, urticaria seems to be the chief, if not the only, evidence of sensitivity to this drug. Keefer1 reports 14 cases of urticaria out of 500 cases treated and Lyons2 12 cases of urticaria out of 209 treated. These reactions from commercial penicillin sodium, if predicated on a sensitization mechanism, are obviously not necessarily due to penicillin itself. During the course of some studies designed to determine whether a correlation exists between the immediate local reactions obtained with certain lots of commercial penicillin sodium on intramuscular injection in man and those obtained by intracutaneous injection of the same material in rabbits and in man, a person, J. D. W., was injected intracutaneously in the left arm with four lots of commercial penicillin sodium representing the products of three different manufacturers. Each injection consisted

Journal

JAMAAmerican Medical Association

Published: Sep 2, 1944

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