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HYPERPARATHYROIDISM WITH ADENOMA CAUSING RENAL FAILURE AND SECONDARY HYPERPARATHYROIDISM: REPORT OF A CASE

HYPERPARATHYROIDISM WITH ADENOMA CAUSING RENAL FAILURE AND SECONDARY HYPERPARATHYROIDISM: REPORT... Abstract It is well recognized that a serious form of renal disease may result from hyperparathyroidism.1 It is also well established that chronic renal insufficiency frequently is associated with secondary hyperplasia of the parathyroid glands.2 On a priori grounds, therefore, one can reason that a paradoxic situation might exist wherein long-standing renal disease resulting from a parathyroid adenoma is so severe as to stimulate further overactivity of the other parathyroid glands. Actually this does occur. Johnson3 reported a case in which removal of a parathyroid adenoma was followed by death from hypertension and uremia four years later, at which time the remaining parathyroid glands showed enlargement and hyperplasia. The following case report is submitted because it is the first to our knowledge in which secondary parathyroid hyperplasia has been proved to coexist with a parathyroid adenoma. REPORT OF CASE A. C., a former insurance salesman, aged 50, entered References 1. Albright, F.; Baird, P. C., and Bloomberg, E.: Studies on Physiology of Parathyroid Glands: Renal Complications of Hyperparathyroidism , Am. J. M. Sc. 187:49-65, 1934.Crossref 2. Albright, F.; Drake, T. G., and Sulkowitch, H. W.: Renal Osteitis Fibrosa Cystica: Report of Case with Discussion of Metabolic Aspects , Bull. Johns Hopkins Hosp. 60:377-399, 1937. 3. Castleman, B., and Mallory, T. B.: Parathyroid Hyperplasia in Chronic Renal Insufficiency , Am. J. Path. 13:553-574, 1937. 4. Shelling, D. H., and Remsen, D.: Renal Rickets: Report of Case Showing Four Enlarged Parathyroids and Evidence of Parathyroid Hypersecretion , Bull. Johns Hopkins Hosp. 57:158-181, 1935. 5. Johnson, J. W., Jr.: Primary Hyperparathyroidism with Extensive Renal Calcification and Secondary Hyperplasia of the Parathyroids: Report of a Case , Am. J. Path. 15:111-123, 1939. 6. Drake, T. G.; Albright, F., and Castleman, B.: Parathyroid Hyperplasia in Rabbits Produced by Parenteral Phosphate Administration , J. Clin. Investigation 16:203-206, 1937.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

HYPERPARATHYROIDISM WITH ADENOMA CAUSING RENAL FAILURE AND SECONDARY HYPERPARATHYROIDISM: REPORT OF A CASE

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Publisher
American Medical Association
Copyright
Copyright © 1941 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1941.00200030188014
Publisher site
See Article on Publisher Site

Abstract

Abstract It is well recognized that a serious form of renal disease may result from hyperparathyroidism.1 It is also well established that chronic renal insufficiency frequently is associated with secondary hyperplasia of the parathyroid glands.2 On a priori grounds, therefore, one can reason that a paradoxic situation might exist wherein long-standing renal disease resulting from a parathyroid adenoma is so severe as to stimulate further overactivity of the other parathyroid glands. Actually this does occur. Johnson3 reported a case in which removal of a parathyroid adenoma was followed by death from hypertension and uremia four years later, at which time the remaining parathyroid glands showed enlargement and hyperplasia. The following case report is submitted because it is the first to our knowledge in which secondary parathyroid hyperplasia has been proved to coexist with a parathyroid adenoma. REPORT OF CASE A. C., a former insurance salesman, aged 50, entered References 1. Albright, F.; Baird, P. C., and Bloomberg, E.: Studies on Physiology of Parathyroid Glands: Renal Complications of Hyperparathyroidism , Am. J. M. Sc. 187:49-65, 1934.Crossref 2. Albright, F.; Drake, T. G., and Sulkowitch, H. W.: Renal Osteitis Fibrosa Cystica: Report of Case with Discussion of Metabolic Aspects , Bull. Johns Hopkins Hosp. 60:377-399, 1937. 3. Castleman, B., and Mallory, T. B.: Parathyroid Hyperplasia in Chronic Renal Insufficiency , Am. J. Path. 13:553-574, 1937. 4. Shelling, D. H., and Remsen, D.: Renal Rickets: Report of Case Showing Four Enlarged Parathyroids and Evidence of Parathyroid Hypersecretion , Bull. Johns Hopkins Hosp. 57:158-181, 1935. 5. Johnson, J. W., Jr.: Primary Hyperparathyroidism with Extensive Renal Calcification and Secondary Hyperplasia of the Parathyroids: Report of a Case , Am. J. Path. 15:111-123, 1939. 6. Drake, T. G.; Albright, F., and Castleman, B.: Parathyroid Hyperplasia in Rabbits Produced by Parenteral Phosphate Administration , J. Clin. Investigation 16:203-206, 1937.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1941

References

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